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Biomedical subjects

H S Gallager

Publications and source records attributed to H S Gallager.

At least 37 records · Page 2Linked to original sources
PubMed1982

Characterization of a cell line (SW756) derived from a human squamous carcinoma of the uterine cervix.

An established cell line, SW756, derived from a primary squamous carcinoma of the uterine cervix is described by its morphology, ultrastructure, karyotype, genetic signature analysis, HLA typing, and tumorigenesis in the nude mouse. Cultured cells obtained from the SW756 derived nude mouse tumor also were studied for chromosome and isozyme markers. The original tumor was poorly differentiated carcinoma with minimal keratinization and is compared with that occurring in the nude mouse after the cultured cells were inoculated. The nude mouse tumor showed similar histological features, but better differentiation than the original tumor. Karyotype analysis of SW756 demonstrated a hyperdiploid stem line number and several marker chromosomes (MI-M6). No HeLa marker chromosomes were identified. The isozyme pattern for SW756 reported by others has been confirmed. The unique chromosome and isozyme features have been identified repeatedly in the cultured cells and, most importantly, in the post nude mouse culture. We recommend SW756 as a defined human tumorigenic cell line derived from a primary squamous carcinoma of the uterine cervix.

Animals↗
PubMed1980

The developmental pathology of breast cancer.

The early stages in the development of breast cancer, from epithelial inception to initial invasion, comprise a predictable, fairly uniform series of events. Once invasion has occurred, behavior is much more random. For this reason, local treatment methods are most effective in these early stages and efforts directed at early detection are thoroughly justified.

Breast↗
PubMed1980

Vulvar Paget's disease: a topographic study.

Four vulvectomy specimens from patients with vulvar Paget's disease were studied by means of subserial total sectioning. In each case, the extent of histologically demonstrable disease was far greater than that of the visible lesion, the outline of the involved area was highly irregular, and multiple foci of disease were present. The implications of the findings for treatment selection, intraoperative management, and histogenesis are discussed.

Adult↗
PubMed1979

Intramitochondrial rod-like inclusions in human breast tumors.

Ultrastructural screening of human breast tumor biopsies has revealed, in 43% of the carcinomas, and in 16% of the benign lesions examined. the presence of rod-like inclusions in mitochondria of epithelial cells. The inclusions are cylindrical in cross section, with a diameter of about 50 nm, and show regular striations in longitudinal sections. They are probably derived from cristae. Mitochondria with inclusions are usually enlarged and are found most frequently in epithelial cells of invasive tumors and near zones of tumor necrosis. Similar although not identical inclusions have been observed by other investigators in the liver of women with hydatidiform mole or choriocarcinoma, of pregnant women, and of women taking oral contraceptives. Identical inclusions have been found in mitochondria of HeLa cells treated with anti-HeLa serum. Although no clear-cut correlations were found between the finding of inclusions and parameters such as age of patients, nuclear grade or lymphocytic infiltration of the breast tumors, it is conceivable that the presence of mitochondrial inclusions reflects the effect of hormonal or of immunological factors.

Adenofibroma↗
PubMed1979

The detection and diagnosis of early occult and minimal breast cancer.

This article has attempted to describe the present status of efforts toward routine detection of breast cancer at a stage when it is readily curable and to point out, not only the potentials of screening programs, but also the problems and difficulties that beset them. We believe that efficient, safe screening and accurate early diagnosis are achievable and that trial directed toward this end should not only continue but expand. We see no other avenue that offers as bright a prospect for a meaningful reduction in breast cancer mortality and the monstrous toll--medical, emotional, sociologic and monetary--it exacts.

Adult↗
PubMed1979

Gonadoblastoma associated with malignant teratoma.

A case of gonadoblastoma associated with malignant teratoma in the contralateral ovary is described. Considerations are offered concerning the malignant potential of dysgenetic gonads as well as the diagnostic and therapeutic approaches in such situations.

Adult↗
PubMed1978

Characterization of an ovarian carcinoma cell line.

A long-term ovarian carcinoma cell line is described in terms of its morphology, original histopathology, electron microscopic features and chromosome features before and after transplantation into an athymic nude mouse. The microscopic features of the tumor nodule grown in the nude mouse are compared with the original pathology. Epithelial characteristics of the cells were maintained in culture and after retrieval from the nude mouse. Three markers were identified in all karyotypes and trisomy was noted in chromosomes 1, 2, 3, 6, 11, 12, 16, and X and monosomy of 17 and 21.

Adenocarcinoma↗
PubMed1977

Carcinoma of the breast: analysis of total lymph node involvement versus level of metastasis.

The histologic presence of axillary lymph node metastasis is the most commonly used indicator or prognosis for patients with operable breast cancer. The record of 385 patients treated by 380 radical mastectomies between the years 1944 and 1972 were reviewed to clarify this. The axillary nodes recovered were evenly distributed. The median number of positive lymph nodes at each level was two; 50% had involvement of only one level. The number of lymph nodes identified increased with the number of positive nodes. When compared with similar patients, survival curves for those having a single involved node and also those having multiple metastatic nodes were similar whether the node were in the proximal, middle, or distal levels. The 10-year determinate survival for patients with fewer than five positive positive nodes was just under 50%. High positive nodal counts, or involvement of more than one level, were associated with local recurrence of disease.

Adult↗
PubMed1977

Carcinoma of the breast: the prognostic significance of extranodal extension of axillary disease.

A retrospective study to determine the effect of extranodal axillary disease on prognosis in invasive carcinoma of the breast was undertaken in a series of 152 cases. It was found that extranodal disease has an unfavorable effect on prognosis in those patients with three or less involved axillary nodes and no effect on prognosis in those patients with four or more involved axillary nodes. Extranodal axillary disease was found to have no influence on the interval between surgery and initial recurrence nor on the anatomic distribution of the recurrence, local or remote.

Axilla↗
PubMed1977

Treatment failure sites according to irradiation technique and histology in patients with endometrial cancer.

Three hundred and seventy-two patients with endometrial cancer treated from 1948 through 1969 and having complete follow-up were reviewed. All patients completed definitive therapy with preoperative irradiation and surgery or irradiation alone and have separated into two main groups: 1) those treated with irradiation by radium alone or 2) those treated with external irradiation plus diminished amounts of radium. Pathology material from each patient was reviewed by one pathologist. Treatment by radium alone led to fewer pelvic failures than did external irradiation plus diminished amounts of radium, when evaluated by stage, grade, and specific histology. Both irradiation modalities led to about the same incidence of failures due to distant metastasis only.

Adenocarcinoma↗
PubMed1977

Prognosis and treatment in minimal breast cancer.

Of 176 patients with minimal breast cancer, 138 had intraductal carcinoma in situ, 21 minimally invasive carcinoma, and 17 lobular carcinoma in situ. Various modalities of treatment were used including radical, modified radical, and simple mastectomy with and without radiation therapy. Long-term postoperative follow-up was available in all but five patients and ranged from one year to twenty-one years. Actuarial analysis projected a twenty year survival of 93.2 per cent for the entire group. Analysis of survival figures based on each of the several treatment modalities showed no definite advantage of one form of treatment over another. The data suggest that minimal breast cancer is a prognostically favorable diagnosis, provided invasive carcinoma is not present or does not develop in the opposite breast. It is also indicated that breast cancer is potentially a bilateral disease and that follow-up and treatment of the opposite breast must be of major concern in the care of these patients.

Adult↗
PubMed1976

Treatment selection in primary breast cancer. Pathologic considerations.

Minimal breast cancer is defined as including in situ lobular carcinoma, noninvasive intraductal carcinoma, and invasive carcinoma forming a mass no greater than 0.5 cm in diameter. Intraductal, intralobular, and microinvasive carcinomas of this degree of development are classed together, and are associated with at most a 10% probability of having associated axillary lymph node involvement. Lesions of this classification have been shown to have a five year survival rate of 97% and a ten year rate of 95%, when they are treated surgically.

Breast Neoplasms↗