[Observation on the effect of camptothecin-dimethyl sulfoxide solution on psoriasis].
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Administration, Topical↗
Biomedical subjects
H S Li
Publications and source records attributed to H S Li.
Partial synthesis of crystalline bovine insulin from synthetic A-chain and natural B-chain.
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Animals↗
Distal hamstring elongation in the management of spastic cerebral palsy.
Forty-nine children with spastic cerebral palsy treated by distal hamstring elongation and followed for an average of 4.4 years were reviewed. The aim of the operation was to release hamstring tightness to improve the patients' level of function and efficiency and the cosmetic appearance of their gait. Forty patients had significant improvement in gait pattern, and 18 had improved motor function. Complications included transient stiff-legged gait and exaggerated lumbar lordosis. One patient with spastic quadriceps had 15 degrees of persistent genu recurvatum.
Adolescent↗
Age-related degeneration of the organ of Corti in two genotypes of mice.
Degenerative changes in the organ of Corti were investigated in two genotypes of mice, CBA/Ca (moderate age-related late-onset hearing loss) and C57BL/6J (spontaneous early-onset auditory deterioration), ranging in age from 1 to 21 months (C57BL) and from 1 to 33 months (CBA). Light, transmission and scanning electron microscopies were used for qualitative and quantitative analyses. Alterations of deterioration in the CBA-mouse cochlea showed a late-onset loss of hair cells, lipofuscin in the outer hair cells (OHCs), giant stereocilia on the inner hair cells and elevated pillar heads. In C57BL mice, the primary lesions of the organ of Corti include early damage of stereocilia on OHCs, missing OHCs, and a ruptured reticular lamina. Giant cilia and elevated pillar heads were not evident in C57BL mice. In the aged C57BL mouse cochlea, the whole organ of Corti was collapsed and replaced by the supporting cells, whilst in the oldest CBA mice, completely normal-looking OHCs still remained even in severely deteriorated areas of the organ of Corti. The results indicate that the patterns of degeneration of the organ of Corti are different between CBA/Ca and C57BL/6J mice, probably under the control of different genes.
Aging↗
Degeneration patterns of actin distribution in the organ of corti in two genotypes of mice.
Alterations of the auditory system during ageing and after noise damage have been studied earlier in two genotypes of mice, CBA/Ca and C57BL/6J, the former of which shows a late-onset hearing loss and the latter a high susceptibility to ageing and acoustic trauma early in life. The two strains display similarities to the different types of human age-related hearing loss. In the present study, the different patterns of hair cell degeneration were visualized by phalloidin-labelled actin in the two strains of mice with increasing age. At 1 month of age there were no major differences in the actin distribution between the two genotypes. With increasing age, CBA mice retained a regular pattern of actin content in the cuticular plate but some hair cells were missing. In contrast, the C57BL mice showed a severely distorted architecture of the cutis plate (CP) with less actin labelling, missing hair cells and scar formation. The instability of actin in the hair cells of C57BL mice might result in their high susceptibility to ageing and noise damage.
Actins↗
Influence of age on noise-induced permanent threshold shifts in CBA/Ca and C57BL/6J mice.
Two inbred strains of mice, CBA/Ca (showing a moderate hearing loss with onset late in life) and C57BL/6J (undergoing spontaneous auditory degeneration with onset during young adulthood), were exposed to a broad-band noise of 120 dB SPL (2-7 kHz) for 5 min at 1,2,3,6 or 12 (only for CBA) months of age. Permanent threshold shifts (PTS) were determined by recording auditory brainstem response (ABR) 1 month after exposure. C57 mice were more severely affected by acoustic trauma than age-matched CBA mice. With increasing age, susceptibility to PTS decreased in CBA mice but remained constant in C57 mice. Results indicate that the auditory system of CBA mice undergoes a progressive resistance to noise damage, whereas the persistent high susceptibility to acoustic trauma in C57 mice may be related to their genetic predisposition to rapid auditory degeneration.
Acoustic Stimulation↗