Biomedical subjects
Publications and source records attributed to H S Narayanan.
We describe the patterns of illness attributed to sorcery among 209 patients who attended a special clinic in south India. Somatisation and conversion disorders accounted for the majority of patients, although several other psychiatric and medical disorders were also seen. Aspects of treatment of such patients in the sociocultural context are discussed.
A young boy presented with mental retardation and seizures with extensive hairy naevi. After a fluctuating clinical course over the next 2 years, he worsened rapidly with signs of rising intracranial pressure. A CT scan revealed unsuspected features of Dandy-Walker syndrome. The clinical course is traced till the patient's death, and the implications of the coexistence of these rare conditions are discussed in view of the proposed hypotheses regarding the pathogenesis of Dandy-Walker syndrome.
Lithium intoxication is well known to produce acute and chronic symptoms but development of permanent neurological deficit is a rarity. Six cases of manic depressive psychosis who developed neurological sequelae following treatment with lithium carbonate are described. There were multiple lesions in the central nervous system. However, the main brunt was borne by cerebellum. The serum lithium levels of five patients were within therapeutic range. The value of identifying the precipitating factors, early diagnosis and prompt intervention in the prevention of persistent neurological dysfunction is emphasized.
Explore the source record for details and available documents.
A longitudinal study of a case report in which bipolar manic-depression was complicated by tardive dyskinesia indicates an antithetical relationship between the severity of tardive dyskinesia and that of depression as well as mania. Reversal of tardive dyskinesia in depression was compatible with the current neurochemical postulates of these disorders. The scarce reports of state-dependent dyskinesias are reviewed in the hope that this can be a useful probe in human studies. Finally, the "undopamine" hypothesis of tardive dyskinesia as a hypernoradrenergic state is discussed and the need for phenomenological-neurochemical characterization of tardive dyskinesia is emphasized.
A mentally retarded male with few Down syndrome features showed a satellited long arm of Y (Yqs) and trisomy 21. Metaphase spreads were studied using Q-, C-, G-banding methods and silver staining.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Studies made in a group of patients with mental retardation showed that there was a high degree of parental consanguinity of the order of 30.3%. Index cases with parental consanguinity showed a relatively higher prevalence where more than one sib was affected. Cases with metabolic defects were also more common among cases with parental consanguinity. There is a need for studies in the general population in order to understand the biological significance of consanguinity.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.