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H S ROSENKRANZ

Publications and source records attributed to H S ROSENKRANZ.

15 recordsLinked to original sources
PubMed1965

PHENETHYL ALCOHOL. I. EFFECT ON MACROMOLECULAR SYNTHESIS OF ESCHERICHIA COLI.

Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), Howard S. Carr, and Harry M. Rose. Phenethyl alcohol. I. Effect on macromolecular synthesis of Escherichia coli. J. Bacteriol. 89:1354-1369. 1965.-An investigation of the mode of action of phenethyl alcohol produced the following results. Phenethyl alcohol had no effect on the physicochemical properties of isolated deoxyribonucleic acid (DNA). The DNA isolated from phenethyl alcohol-treated bacteria had physicochemical properties identical with those of DNA isolated from normal cells. The metabolic functions most sensitive to the inhibitory action of phenethyl alcohol appeared to be the process of enzyme induction and, possibly, the synthesis of messenger ribonucleic acid. Phenethyl alcohol did not affect the polyuridylic acid-mediated synthesis of polyphenylalanine in a cell-free amino acid-incorporating system.

Alcohols↗
PubMed1965

PHENETHYL ALCOHOL. II. EFFECT ON THYMINE-REQUIRING ESCHERICHIA COLI.

Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), Howard S. Carr, and Harry M. Rose. Phenethyl alcohol. II. Effect on thymine-requiring Escherichia coli. J. Bacteriol. 89:1370-1373. 1965.-Phenethyl alcohol (PEA) at levels (0.05%) presumed to interfere with messenger ribonucleic acid synthesis also inhibits thymineless death, when the agent is added prior to the exponential killing phase. The addition of more concentrated solutions of PEA (0.5%) during this initial starvation leads to an immediate killing. Identical results were obtained when 0.5% PEA was added to cells growing in the presence of thymine. The addition of this high level (0.5%) of PEA to bacteria undergoing thymineless death results in the rescue of the survivors.

Alcohols↗
PubMed1964

PURINE- AND PYRIMIDINE-SPECIFIC ANTIBODIES: EFFECT ON THE FERTILIZED SEA URCHIN EGG.

Antiserums from rabbits immunized with several purine- and pyrimidine-containing albumin conjugates can penetrate and become fixed within cells of Arbacia punctulata. All of these specific antiserums were found to inhibit embryonic development of the fertilized sea urchin egg. The stage of arrestment of development was dependent in part upon the dilution of antiserum, and also upon the nature of its specificity. It is suggested that the observed results reflect the interaction of these antiserums with singlestranded DNA within the cell.

Animals↗
PubMed1964

MACROMOLECULAR SYNTHESIS AND THE BACTERICIDAL EFFECT OF STREPTOMYCIN.

Rosenkranz, Herbert S. (Columbia University, New York, N.Y.). Macromolecular synthesis and the bactericidal effect of streptomycin. J. Bacteriol. 87:606-603. 1964.-Hydroxylamine, a bacteriostatic agent which inhibits deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and protein synthesis, interferes with the lethal action of streptomycin on growing cells of Escherichia coli. The addition of hydroxylamine to cultures exposed for various times to streptomycin prevents the further killing of the survivors. On the other hand, phenethyl alcohol, a chemical which interferes with DNA synthesis, does not reverse the action of streptomycin. From this and the mode of action of hydroxylamine, it is suggested that the structural and functional integrity of RNA is required for the bactericidal action of streptomycin.

Anti-Bacterial Agents↗
PubMed1963

LETHALITY OF STREPTOMYCIN FOR ALKALINE PHOSPHATASE CONSTITUTIVE ESCHERICHIA COLI.

Rosenkranz, Herbert S. (Columbia University, New York, N.Y.) and Howard S. Carr. Lethality of streptomycin for alkaline phosphatase constitutive Escherichia coli. J. Bacteriol. 85:751-753. 1963.-An alkaline phosphatase constitutive strain of Escherichia coli was more sensitive to streptomycin in a phosphorus-rich medium than was the wild parent strain. In a low-phosphorus medium, the efficiency of killing by streptomycin was nearly the same for both strains. The greater sensitivity displayed by the alkaline phosphatase constitutive strain in the phosphorus-rich medium was ascribed to the absence of internal inorganic phosphates in these bacteria. It has been shown that such anions interfere in the reaction of the antibiotic with deoxyribonucleic acid.

Alkaline Phosphatase↗