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H Sagua

Publications and source records attributed to H Sagua.

33 records · Page 2Linked to original sources
PubMedDate not supplied

[Chronic Chagas cardiomyopathy. Serologic and anatomopathologic study].

In order to contribute to a better knowledge of the chronic chagasic myocardiopathy, a post-mortem serological and anatomopathological study of Chagas' disease was carried out in 40 corpses. Between november 1987 and august 1988, autopsies were performed at the Pathological Anatomy Service of Antofagasta Regional Hospital and the Legal Medicine Section of the Ministry of Justice in Antofagasta. Positive postmortem chagasic serology, by using an indirect immunofluorescence test in pericardial fluid, was confirmed in three cases, among which the study of the histopathology of the cardiac muscle showed "Trypanosoma cruzi type" elements of the damage. The macroscopic morphological study did not show relevant findings. Results reveal the need to implement anatomopathological study systems for routines which contribute to evaluate the chagasic etiology as a cause of death among population of the endemic Chilean area.

Adult↗
PubMedDate not supplied

[Levels of anti-Gal antibodies in persons infected and non-infected with Trypanosoma cruzi. Probably induced by bacteria and by the parasite].

Antibodies levels against Gal alpha 1,3 Gal epitopes were studied in 407 human sera (92 chagasic and 315 non-chagasic), by means of hemagglutination with rabbit erytrocytes reactivity of serum having high titres of anti-Gal antibodies in presence of Escherichia coli and Serratia marcescens antigen was studied by immunoelectrotransference. Finally, using a purified anti-Gal antibody, Gal alpha 1,3 Gal epitopes were identified in metacyclic forms from 12 high Andean Chilean strains of Trypanosoma cruzi. Among the chagasic sera, it was demonstrated that in 63 (68.5%) were detected antibodies anti-Gal at the same or higher titer than 1:1,600; while i the non chagasic sera only 49 (15.6%) showed and anti-Gal response at similar titers. Immunoelectrotransference showed that the sera of people infected with T. cruzi recognize antibodies present in E. coli and S. marcescens, which reinforces the idea that at least in part, these bacterias would be capable of stimulating these responses. The autoradiographic analysis using purified anti-Gal antibodies, showed differences in the Gal alpha 1,3 Gal epitopes expressed in the different strains of T. cruzi. These results suggest that anti-Gal antibodies could have a real significance on the natural immunity mechanisms and protection of human infection with T. cruzi.

Animals↗
PubMedDate not supplied

[Chagas disease in northern Chile. Serological prevalence in pregnant women of the city of Antofagasta, 1991-1993].

Antofagasta, the big city-port in North Chile is a triatomines free locality. Chagas infection was serologically diagnosed in 44 out of 2063 (2.1%) pregnant women from Antofagasta, studied by means of an indirect immunoflourescence test (IIFT), during 1991-1993. Out of the 44 seropositive mothers, 31 and 10 were born in the II (moderate endemic area) and IV Región (hiperendemic area), respectively. The usefulness of a screening programme for congenital Chagas' disease at primary health care in Chile is discussed.

Adolescent↗
PubMedDate not supplied

[Current human and canine seroprevalence of Chagasic infection in San Pedro de Atacama County, II Region of Antofagasta, Chile, 1995].

In order to assess the impact of a control program against Triatoma infestans launched in 1988, based on insecticide spraying of dwellings, a serological survey for chagasic infection was carried out during 1995 in three localities from San Pedro de Atacama County (22 degrees 55' South lat., 68 degrees 12' West long.), II Region of Antofagasta in northern Chile. Blood samples from 531 children and adolescents and 65 dogs were subjected to ELISA test and indirect immunofluorescent test for Chagas' disease respectively. Tests resulted positive in 12 (2.3%) persons, all above 5 years old, in contrast with the 16.8% serological positivity observed in 1985. Three (4.6%) dogs (two 0-12 months old) resulted positive. These results indicate that dwelling sprayings with long-term activity insecticides against T. infestans is a good tool to prevent new human infections with T. cruzi. However, active vector transmission among domestic animals (canines) could be recently acquired.

Adolescent↗
PubMedDate not supplied

[Epidemiological study of pediculosis capitis and scabies in schoolchildren from Antofagasta, Chile, 1995].

In order to contribute to a better knowledge of the pediculosis capitis and scabies during March-December 1995, 1122 primary schoolchildren under 14 years of age in the city-port of Antofagasta in northern Chile (20 degrees South lat.), were examined. A total of 285 (25.4%) were found to be infested with Pediculus humanus capitis and only 20 (1.8%) with Sarcoptes scabiei. In general the rates of infestation to both ectoparasitic diseases were higher in groups of younger schoolchildren, also higher in women than in men and in those groups with high indexes of crowding and ignorance of the transmission mechanism of pediculosis capitis and scabies.

Adolescent↗
PubMedDate not supplied

[Activity of Dipernoids isolated from Azorella compacta (Llareta) on Trypanosoma cruzi amastigotes].

The trypanocidad activity against amastigote forms of SPA-14, Tulahuen and G strains and CL Brener clone of Trypanosoma cruzi of diterpenoids isolated from Azorella compacta, Phil. (Llareta), a plant with ethnomedicinal prestige from prespanish age, was investigated. Amastigocidal activity was shown in azorellanol (2), diterpene isolated by first time, with an inhibitory concentration 50 (IC50) that varied between 60 M (CL Brener clone) and 84 M (SPA-14 strain), and in mulin -11,13 -dien-20-oico acid (5) with IC50 between 41 microM (G strain) and 87 mM (CL Brener clone). The cytotoxicity levels of both compounds against Hela and Vero cells and macrophages J144 are lower than nifurtimox and similar to gentian violet.

Animals↗