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Biomedical subjects

H Sajonski

Publications and source records attributed to H Sajonski.

At least 19 recordsLinked to original sources
PubMed1979

[Quantifiable morphokinesis of parts of the hypothalamo-adenohypophyseal-gonadal axis of hormonally desexed boars. 4. Studies on boars that have undergone combined treatment with the steroid test substance 547 and norgestrel].

Steroid test substance 547 and Norgestrel were used in a combination treatment of parts of the hypothalamo-adenohypophyseo-gonadal axis of boars. The quantifiable parameters of the morphokinetic effect thus produced (cell nucleus volumes of Nucleus praeopticus medialis hypothalami and its neurons as well as those of Leydig's cells testicle weight, length and diameter of tube, percentage of Leydig's cells, testicle weight, length and diameter of tube, percentage of Leydig's cells) did not differ significantly from the findings obtained from boars treated with Norgestrel only (cf. Dorst and co-workder, 1978). The same combination treatment, however, differed from exclusive Norgestrel treatment by causing the occurrence of socalled castration cells, which led to the assumption of an anti-androgenic effect of such combination treatment.

Androstenes↗
PubMed1978

[Quantifiable morphokinesis in members of the hypothalamo-adenohypophyseogonadal axis of hormonally castrated boars. 2. Studies on norgestrel treated boars].

Norgestrel treatment of boars differed from analogous chloromandinone acetate treatment in that no significant morphokinetic effect was recordable from all parts of the hypothalamic-adenohypophyseal-gonadal axis. The morphometric parameters as well as the histological pattern obtained of the anterior lobe of the pituitary gland appear to prove that in boar the antigonadotropic effect of norgestrel is lower than that of chloromadinone acetate, with dosage and duration of treatment identical.

Animals↗
PubMed1978

[Quantifiable morphokinesis of parts of the hypothalamo-adenohypophyseal-gonadal axis in hormonally castrated boars. 3. Studies of boars following treatment with steroid test substance 547].

Morphokinetic effects caused in parts of the hypothalamic adenohypophyseogonadal axis of boars by treatment, using No. 547 steroid test substance (ZIMET, Jena) were to some extent identical with those resulting from analogous CAP application (inhibition of testicular androgen producers, anterior lobe of the pituitary gland, nucleus praeopticus medialis) or those following analogous norgestrel treatment (testes weight, tubule length). The findings recorded were largely attributed to the androgenic properties of No. 547 steroid test substance.

Androstenes↗
PubMed1978

[Quantifiable morphokinesis on parts of the hypothalamo-adenohypophyseal-gonadal axis of hormonally castrated boars. I. Studies on boars treated with chlormadinone acetate].

A clearly morphokinetic effect was recorded from the parts of the hypothalamo-adenohypophyseo-gonadal axis in boars that had been treated with chloromadinone acetate (CAP). Luteinising hormone release is inhibited by CAP, which is reflected in an increase of luteinising hormone cells in their storage form. This leads to statistically significant decline in androgenic testicular tissue percentage and in the cell nucleus volumes of Leydig's cells. Excessive weight decrease of the testicle is caused primarily by some 60 per cent reduction in tube length. The neurons of the tested hypothalamic nuclear region, that is the nucleus praeopticus medialis, have shown that in treated animals cell nucleus volumes were significantly depressed.

Animals↗
PubMed1976

[Endocrine and spermatogenic testicular function. 2. Correlations between food protein quality, testosterone level in testes, spermatogenesis and nuclear volume of interstitial cells of Leydig in the adult rat].

Male adult Wistar rats were given different food proteins through 21 days, including casein and four-per-cent methionine (K diet), maize gluten with amino acid added (M + As diet), maize gluten alone (M diet), and casein with four-per-cent methionine mixed one to three with gelatin (K/G diet). Testicular testosterone levels per 100 g live weight were about 411 ng (in animals aged 130 days) or 326 ng in animals aged 160 days) following 21 days of K or M + As feeding (rRP = ten per cent). Roughly 70 per cent of those values were obtained by M or K/G feeding. The use of 20 per cent rRP gave 342 ng in connection with M + As feeding or 289 ng when it accompanied M feeding (the latter figures being recorded from animals aged 160 days). The eight cyclic phases of the germinal epithelium were completely development, independent of RP quality, in all test animals. The nuclear volume of the interstitial cells of Leydig responded with highly significant variation (p less than 0.01) to diets with ten per cent rRP of different qualities, but no significant morphokinetic effect was recorded by karyometric from diets with 20 per cent rRP.

Animals↗
PubMed1976

[Endocrine and sperminogenic testicular function. 8. Relationships between testicular and plasma testosterone concentrations as well as between the number of Leydig cells in testicular tissue and their cell nucleus volume in boars of different ages].

Testicular tissue and blood samples (V. spermatica interna) were taken from 32 boars during castration. The animals were different age groups. Against this background, studies were conducted into the correlations between testicular and plasma testosterone, on the one hand, and the amount of interstitial cells of Leydig in testicular tissue as well as the latters' cell nuclei volumes, on the other. The results seemed to support the conclusion that any age-dependent increase of testicular and plasma testosterone concentrations was caused unambigously by an absolute increase in volume of androgenic testicular tissue, in concomitance with testicular growth, in other words, by rise in the total number of interstitial cells of Leydig.

Age Factors↗
PubMed1976

[Endocrine and spermatogenic testicular function. 9. Correlations between plasma testosterone and morphometric parameters of the testis in boars of different ages].

Close, statistically fully secured correlations were found to exist in boars, aged between four and four-a-half as well as seven and nine months, between the testosterone content in the blood of the V. spermatica interna, on the one hand, and morphometric parameters essential to quantitative sperm production, on the other (testicular volume, volume of germinativum, overall length of tubules, diameter of tubules, and cell density of the germinal epithelium).

Age Factors↗
PubMed1976

[Studies on endocrine and spermiogenic testis function. III. Relationships between the quality of dietary proteins, testosterone content of the testes and cell nucleus volume of the Leydig cells during postnatal developme-t of rats].

Male Wistar rats, aged 15 days, received different qualities of feed proteins through 80 days (absorbable crude protein-rRP = ten per cent). For experimentation, the animals were subdivded into four groups. The first group was given casein plus four per cent methionine (K), the second maize gluten with amino acid added (M + As), the third maize gluten only (M), and the fourth casein plus four per cent methionine mixed one to three with gelatin (K/G). Live weight increases after ten days of feeding were 34+/-13.9 g (K), 24+/-8.5 g (M + As), 8+/-5.7 g (M), and 0+/-3.6 g (K/G). The same trend was recorded from testicular weight which was measured as well in ten-day intervals. The eight cyclic phases of the germinal epithelium were completely developed as of the 45th day of age in animals on K and M+/-As rations and as rations and as the 95th day of age in animals on K/G ration (followed improvement to 2:3). Spermatide transformation still was a bit differentiated by histological examination of animals on M diet on the 95th day of experimentation. The testosterone levels in testicular tissue were about 220 ng/100 g live weight after 80 days of K or M + As diets, but only 100 ng/100 g live weight after K/G or M feeding. The nuclear volumes of the interstitial cells of Leydig exhibited significant variation (p less than 0.01) between the 35th and 45th days of age, but went stable to approximately 50 mum3, independent of feed protein quality, at the onset of suxual maturity, on the 95th day of age. Complete formation of all eight cyclic phases of the germinal epithelium seems to depend on limiting values relating to testosterone per gram of testis, testicular weight nuclear volume of the interstitial cells of Leydig and live weight.

Animals↗
PubMed1976

[Studies on endocrine and spermiogenic testis function. IV. Relations between the testosterone content of the testes cell nucleus volume of the Leydig cells and rat spermatogenesis (deduced from studies on the effect of the dietary protein quality on the function of the testes)].

The following relations were derived from large-scale testing of feed protein quality and its bearings on testicular function in growing Wistar rats: testicle weights and live weights r = 0.77 for juvenile animals and r = 0.36 for adult animals; nuclear volumes of Leydig's cells to testicle weights r = 0.84 for juvenile animals and r = 0.43 for adult animals; testosterone in testicular tissue, ng/g, to testicle weights r = 0.55 for juvenile animals and r = 0.80 for adult animals; testosterone per live weight, ng/100 g, to nuclear volumes of Leydig's cells r = 0.76 for juvenile animals and r = 0.46 for adult animals. Critical thresholds above which complete spermatogenesis is always ensured may be established for testosterone (50+/-5 ng/100 g live weight) and for the nuclear volume of Leydig's cells (30 mum3). Another conclusions drawn from the above results is that high testosterone levels in the testes of adult animals were not attributable to high testosterone biogenesis of Leydig's cells, as might have been assumed from high activities of that kind recordable from some nuclear volumes.

Animals↗
PubMed1974

[The cell structure of the subcutis of the guinea pig].

The cytological status of subcutis of five normal male guinea pigs was studied qualitatively and quantitatively on the basis of membranous preparations stained by the method of Jasswoin (1932). The major part of the cells are fibroblasts (70,27 +/- 0,58%). 88,17 +/- 3,02% of this cell type are monoplasmatic fibroblasts. The second frequent cell type are histiocytes (27,84 +/- 0,78%). Mastcells are present only on the neighbourship of vessels. Leucocytes are found in 1,89 +/- 0,57%.

Animals↗