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Biomedical subjects

H Sanli

Publications and source records attributed to H Sanli.

8 recordsLinked to original sources
PubMed2006

Cutaneous, pulmonary and hepatic sarcoidosis associated with autoimmune complications during interferon-alpha treatment for hepatitis C virus infection.

A patient with hepatitis C virus (HCV) infection was diagnosed with cutaneous, pulmonary and hepatic sarcoidosis following interferon alpha therapy. There are only a few cases of sarcoidosis associated with this treatment. This is the first case who not only developed sarcoidosis, but also autoimmune hypothyroidism and thrombocytopenia during interferon alpha therapy due to the immunomodulatory effects of the drug.

Antiviral Agents↗
PubMed2003

Post-transfusion acute graft versus host disease in a 17-year-old girl with a malignant mesenchymal tumor--report of a case.

Post-transfusion graft-versus-host disease (PT-GVHD) is seldom, but it has a high mortality rate, exceeding 90 percent. There is no standard treatment for PT-GVHD and irradiation of blood and its components before transfusion is broadly accepted for the prevention of PT-GVHD. In this report we present a case (a 17-year-old female) of PT GVHD, who died in spite of the use of all available therapeutic options.

Adolescent↗
PubMed2000

Abnormal positive potentials in round window electrocochleography.

OBJECTIVE: To describe an atypical waveform, termed an abnormal positive potential (APP), on round window electrocochleograms (RW ECochG) of children and to relate its occurrence to clinical history. STUDY DESIGN: APPs were identified prospectively, and a retrospective analysis was made of these patients' clinical histories, audiograms, and auditory outcomes (hearing aid, cochlear implant, or nonauditory communication) SETTING: Tertiary referral teaching hospital, day surgery and clinics. PATIENTS: All 431 children <110 months of age suspected of a severe to profound hearing loss who underwent RW ECochG from January 1993 to August 1997. INTERVENTION: Diagnostic RW ECochG for auditory threshold estimation. MAIN OUTCOME MEASURE: The presence on the RW ECochG of the APP: an early positive potential in the absence of a compound action potential (CAP). RESULTS: An APP was observed in 34 children. The APP was most marked in response to clicks and 8-kHz tones. The APP click threshold averaged 70 dB hearing loss. The brainstem evoked potential of these children showed an absence of waves, or a broad positive wave with no subsequent waves. Twenty-nine of 30 behavioral audiograms obtained were indicative of severe to profound hearing loss. Auditory outcomes were available from 26 children; 45% of them derived no help from a hearing aid, and 8 children received a cochlear implant. Clinical factors frequently associated with APP were prematurity in combination with kemicterus or hypoxia. CONCLUSIONS: APP thresholds were lower than neural thresholds or behavioral thresholds. Children with APP need close follow-up, because half of those studied needed nonauditory strategies to develop effective communication.

Audiometry, Evoked Response↗
PubMed1997

Use of transtympanic round window electrocochleography for threshold estimations in children.

OBJECTIVE: This study aimed to evaluate the efficacy of round window electrocochleography for the estimation of hearing thresholds in difficult-to-test children. STUDY DESIGN: The study was a retrospective analysis. SETTING: A standard day-stay operating room was used. PATIENTS: Round window electrocochleography was performed on 198 children between January 1993 and January 1996. INTERVENTION: The intervention was diagnostic. MAIN OUTCOME MEASURE: Clinically reliable pure-tone audiograms were obtained in 101 patients (50.9%) for comparisons of electrocochleography and behavioral thresholds. RESULTS: The mean differences between electrocochleography and behavioral thresholds at 0.5, 1, 2, and 4 kHz were less than 6 dB. Ninety-seven percent of the results were within +30 to -30 dB, and approximately 86% of the results were within +20 to -20 dB. Good correlation coefficients of 0.83, 0.84, 0.91 and 0.88 were found between electrocochleography and behavioral thresholds at 0.5, 1, 2, and 4 kHz, respectively. Only 2 of 395 ears were complicated postoperatively by suppurative otitis media. There were no anesthetic complications. CONCLUSION: Round window electrocochleography can be used in conjunction with other audiometric methods for threshold estimations in the difficult-to-test children and as part of the preoperative assessment for cochlear implantation.

Adolescent↗
PubMed1997

Waveforms of cochlear implant-evoked auditory brain stem responses in anesthetized young children, recorded with a new preamplifier.

An ultra-low-noise preamplifier has been specifically designed for the conditions in lightly anesthetized young children, to record cochlear implant--evoked auditory brain stem responses (impEABRs). The preamplifier linearly filters out the signal from the radio-frequency implant-driver. The preamplifier provides simultaneous accurate records of the stimulus-current artifact and impEABR, both ipsilaterally and contralaterally. It is convenient to label electrically evoked vertex-positive peaks, eg, eII, on probable analogy with acoustically evoked potentials. In order to label all the commonly observed peaks with latency less than 5 milliseconds, it is necessary at times to use labels eIIa, eIIb, eIIIa, eIIIb, eIVa, eIVb, eVa, and eVb. The records also show two distinct nadirs, with latencies about 2.5 milliseconds and about 6 milliseconds. The details of the waveforms are preserved as the stimulus strength descends towards threshold.

Age Factors↗
PubMed1995

Waveforms of cochlear implant-evoked auditory brain stem responses in anesthetized young children, recorded with a new preamplifier.

An ultra-low-noise preamplifier has been specifically designed for the conditions in lightly anesthetized young children, to record cochlear implant-evoked auditory brain stem responses (impEABRs). The preamplifier linearly filters out the signal from the radio-frequency implant-driver. The preamplifier provides simultaneous accurate records of the stimulus-current artifact and impEABR, both ipsilaterally and contralaterally. It is convenient to label electrically evoked vertex-positive peaks, eg, eII, on probable analogy with acoustically evoked potentials. In order to label all the commonly observed peaks with latency less than 5 milliseconds, it is necessary at times to use labels eIIa, eIIb, eIIIa, eIIIb, eIVa, eIVb, eVa, and eVb. The records also show two distinct nadirs, with latencies about 2.5 milliseconds and about 6 milliseconds. The details of the waveforms are preserved as the stimulus strength descends toward threshold.

Amplifiers, Electronic↗
PubMedDate not supplied

A case of Netherton's syndrome with cerebral infarction.

Netherton's syndrome, a rare congenital disease of childhood, is characterized by variable cutaneous erythematous eruptions with different manifestations. A five-year-old boy, who presented with ichthyosis linearis circumflexa, atopic manifestations and pili torti, had spastic hemiparesia due to cerebral infarction. Netherton's syndrome can easily be misdiagnosed as Leiner's disease, generalized psoriasis or nonbullous congenital ichthyosiform erythroderma, especially in the neonatal period, because of its nonspecific clinical and histological features. Pediatricians should consider this syndrome in the differential diagnosis of the generalized erythematous skin disorders of childhood associated with various abnormalities.

Abnormalities, Multiple↗