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Biomedical subjects

H Schönenberg

Publications and source records attributed to H Schönenberg.

At least 19 recordsLinked to original sources
PubMed1992

Hyaluronidase enhances the activity of adriamycin in breast cancer models in vitro and in vivo.

The effect of hyaluronidase and a combination of hyaluronidase with Adriamycin was investigated on several breast cancer models in vitro and in vivo. In vitro enzyme treatment (using concentrations up to 80,000 IU/1) of murine (MXT-, MXT +/-, and MXT+) and human (MCF-7, ZR-75-1 and T-47-D) breast cancer cell lines did not inhibit tumour cell proliferation (measured by a kinetic crystal violet assay) in either case. Although high-dose hyaluronidase (1.2 x 10(6) IU/kg) was ineffective, when administered peritumourally to the MXT M3.2 mammary carcinoma of the B6D2F1 mouse, it is remarkable that five "megadoses" were excellently tolerated. However, the antineoplastic activity of Adriamycin against the oestrogen-receptor-positive variant of the MXT tumour was significantly enhanced by combination with concentrations of hyaluronidase that were inactive per se, both in vitro and in vivo. Interestingly, the enhancement of the in vivo antitumour activity was not compromised by toxic side-effects.

Animals↗
PubMed1977

[Alport syndrom (author's transl)].

A deaf-and-dumb patient died at the age of ten of failure of the kidneys. An uncle of the boy died at the age of 42, an aunt at the age of 16 years, both of atrophic kidneys. The mother of the proband is suffering from hard hearing on one side and recurrent episodes of pyuria. Repeated examinations in two aunts revealed slight pyuria resp. erythruria. Contrary to most reports affected members of the family showed pyuria rather than haematuria. A special inheritance could not be proved.

Child↗
PubMed1977

[Phenyketonuria associated with Rubinstein-Taybi syndrome, spondylic dysplasia, left vascular shrinking of adrenal gland (author's transl)].

Report of a 10 year old girl, who demonstrated the following diseases independent from each other: Phenylketonuria, Rubinstein-Taybi syndrome, dysplasias of the skeleton, especially dysplasia of the vertebra and finally, left-sided shrinkes adrenal gland, which caused presumably an increased production of androgens with a premature pubarche.

Abnormalities, Multiple↗
PubMed1976

[Bilateral aplasia of the proximal part of fibula (author's transl)].

Report of an infant with aplasia of the proximal part of the fibula on both sides; by our knowledge the second observation in the literature. Furthermore the infant shows an aplasia of the thyroidea, a coarctation of the aorta, an atrial septal defect and an intraperitoneally situated ascending as well as descending colon.

Abnormalities, Multiple↗
PubMed1976

[Seckel syndrom (author's transl)].

Report of a girl, aged twenty-one months with the typical symptoms of the Seckel Syndrom: Low initial weight in spite of normal resp. prolonged pregnancy, characteristical "bird headed face", mikrocephaly, shortening, general dystrophy, stato-motorial and mental retardation.

Abnormalities, Multiple↗
PubMed1975

[Osteopoikilia with dermofibrosis lenticularis disseminata (Buschke-Ollendorf syndrome) (author's transl)].

In a family, we have observed through 3 generations a Buschke-Ollendorf syndrome. All 12 children and grandchildren, descendants from actually 59 year old grandmother were examined. 8 probands had a osteopoikilia, 5 of them as the grandmother had a dermatofibrosis lentcularis disseminata. The Buschke-Ollendorf syndrome is not really a syndrome in his strong sense, rather a variant of osteopoikilia with participation of skin.

Adolescent↗