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Biomedical subjects

H Schröer

Publications and source records attributed to H Schröer.

At least 19 recordsLinked to original sources
PubMed1996

Relevance and reliability of Ludwig's scientific conceptions of the physiology of the microcirculation.

Modern research into the physiology of the blood circulation has been influenced decisively by Carl Ludwig. His contributions to the special field of microcirculation are typical examples of his scientific mode of thinking, being characterised by exactness and richness of ideas. His demand for a useful division of the complete circulatory system into two parts, namely the intra- and extravascular circulation, has remarkable heuristic value. His ideas concerning the functions of the extravascular space have maintained their validity up to the present day. His conception of the existence of open connections between the interstitial compartments and the inside of the lymphatic vessels was far ahead of contemporary knowledge: the relevant findings and ideas of Ludwig look, in part, like "confirmations" or anticipations of modern investigation results. This is illustrated by corresponding examples. As far as his scientific conceptions are concerned Ludwig was very particular to abstain from admission of any hypothetic throughts into them. The high reliability of his conceptions resulting from this custom is exemplified by comparing his interpretation of fluid and substance exchange in the terminal vessel area with "Starling's law" as the currently accepted explanation of these processes.

Blood Circulation↗
PubMed1978

Cathodoluminescence technique combined with blue light fluorescence microscopy for the investigation of the transport of molecules through the extravascular space of mammalians.

The mechanisms of transport of molecules across the extravascular spaces represent an open problem. Vital microscopic results with marked proteins using the blue light luminescence technique indicate a movement of fluid along the connective tissue fibres. Furthermore, the findings suggest that the elastic fibres play an important role in this movement. It may also be possible to elucidate the extravascular pathway for molecules by means of the cathodoluminescence technique in the scanning electron microscope. The investigations were performed using the mesentery of mammalians anaesthetized by Nembutal. The biological material for cathodoluminescence applications was selected from animals without injection of luminescent dye as well as with animals following intravenous injection of marked proteins. Two techniques, critical point drying and freeze drying, were used in the preparation. Stained and unstained tissues were investigated in the scanning electron microscope with a special cathodoluminescence detector system. Simultaneously observations of the tissue surfaces were performed by means of the secondary electron or backscattered electron mode. The results obtained agree with the findings observed by the blue light fluorescence microscopy and confirm the concept of an extravascular fluid pathway along the elastic fibres in the tissue.

Animals↗