Biomedical subjects

H Seda

Publications and source records attributed to H Seda.

10 recordsLinked to original sources

PubMed1989

The elderly patient: a special case.

The elderly population represents an increasing part of the population, as life expectancy lengthens. As a consequence, rheumatic diseases, especially osteoarthritis, which is highly correlated with age, is increasingly prevalent. NSAIDs, the basic treatment of rheumatic diseases, are thus more and more widely prescribed to elderly patients. These patients must be regarded as a special population because of physiologic changes in absorption, distribution and excretion of drugs due to concomitant treatments of diseases (frequent in the elderly) which may alter metabolism. Specific studies have to be conducted in elderly patients in order to improve the evaluation of the benefit/risk ratio of drugs widely prescribed for this population. This explains why this symposium is devoted to NSAIDs and elderly.

Aged↗

PubMed1986

Efficacy of auranofin as demonstrated by improvement in clinical parameters and decrease in anti-inflammatory usage: a long-term, multicenter study.

An open, noncomparative study at 8 rheumatology centers in Brazil assessed the efficacy and safety of auranofin (AF) when given for up to 24 months. The study enrolled 80 patients with classic or definite rheumatoid arthritis (RA); disease was severe in 20 (25%), moderate in 55 (69%), and mild in 5 (6%). Patients received auranofin, 3 mg twice daily, and varying doses of anti-inflammatory drugs (aspirin, nonsteroidal anti-inflammatory drugs, and corticosteroids). Sixty patients (75%) completed the full 24 months of therapy. No patients were withdrawn from therapy because of insufficient therapeutic effect. There was statistically significant improvement (p less than 0.001) in 9 clinical parameters of disease activity, evident as early as 3 months after beginning AF therapy, increasing steadily over 12 months, and remaining at improved levels for another 12 months. Improvements in some parameters were particularly striking. By 24 months, assessment of well-being had increased by 150%, intensity of pain had decreased by 66%, and duration of morning stiffness had decreased by 78%. The average daily dose of anti-inflammatory drugs also decreased over time. The safety profile of AF was similar to that found in comparable trials. Ten patients (12.5%) were withdrawn because of adverse events: 6 for diarrhea (7.5%), 2 for proteinuria (2.5%), and 1 each for pruritus and anemia (1.25%). Adverse events occurred in 24 of 80 patients; some reported more than one adverse event. The most common adverse events were loose stools (20 patients) or diarrhea (11 patients).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1968