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H Seeliger

Publications and source records attributed to H Seeliger.

At least 19 recordsLinked to original sources

[The value of fine needle puncture in adrenal gland tumors].

UNLABELLED: The value of fine needle biopsy (FNB) in adrenal masses was investigated in 33 patients presenting with such masses. Representative material was obtained 18 times from 19 patients with a history of tumour. 4 of them were diagnosed to be genuinely benign and 14 to be genuinely malignant. Further representative material was obtained 13 times from 14 patients with incidental findings of adrenal masses. The material gained by puncturing was classified correctly as benign in 9 cases, and twice it was considered benign although the tumours later proved malignant. In one case a clinically not suspected malignant lesion was detected by FNB, while in another case a malignant lesion was suspected by FNB, whereas a benign tumour was proven by means of surgery. The share of malignant diagnoses corresponded with the size of tumour, ascertained by the application of ultrasound or CT. The rate of malignant adrenal masses, which were found incidentally, increased from 7 cm onwards; however, the rate of malignant adrenal masses obtained from patients with a history of tumour increased distinctively already from 4 cm onwards. From 11 patients out of 33, adrenal tissue was obtained and classified as benign lesion (adenoma), although, by means of FNB and the conditions for reasons of method, a well differentiated carcinoma cannot be excluded. CONCLUSION: FNB is indicated for non-functioning tumours examined in patients with a history of tumour, furthermore, for incidental findings of the size between 4-6 cm. A diagnostic approach to adrenal masses is suggested.

Adrenal Cortex Neoplasms

Endoscopic polypectomy and management of colorectal adenomas with invasive carcinoma.

BACKGROUND AND STUDY AIMS: Invasive carcinoma is found at histology in 2-5% of colorectal polyps removed under flexible endoscopy. The aim of this study was to confirm that histologically complete endoscopic polypectomy under favorable low-risk conditions is sufficient therapy for pT1 carcinoma, while tumors at or close to the margin of the polypectomy, and histological high-risk criteria, require surgical resection with lymphadenectomy. PATIENTS AND METHODS: Eighty-six patients with 87 pT1 carcinomas underwent polypectomy within a twelve-and-a-half-year period. Further treatment prospectively followed the above guidelines. The follow-up was documented. RESULTS: A local tumor residue was found in 5 of 34 patients who had undergone surgical resection for doubtful or incomplete polypectomy. Two patients were found to have nodal disease in the surgical specimen, only one of them harboring a high-risk carcinoma. Two further patients with high-risk carcinomas had tumor progression, despite postpolypectomy resections without local tumor residue or lymph-node infiltration, and died. One patient had a local tumor recurrence on follow-up endoscopy eight weeks after doubtfully complete polypectomy. He underwent resection, and had no further recurrence. No further manifestations of invasive carcinoma occurred after complete polypectomy of 42 patients with low-risk carcinomas. CONCLUSIONS: This study supports the view that complete endoscopic polypectomy is an adequate therapy for low-risk carcinoma: A modification of the follow-up regimen, with less frequent endoscopic controls, is justified.

Adenoma

[Benign chondroma of the pancreas].

Fragments of a puncture cylinder were obtained from a pancreas tumour, using the ultrasound-guided fine-needle puncture. The tumour appears as an echo-poor, homogeneous structure suggesting good delineation against the adjoining tissue. Histological examination of the punch cylinder revealed a chondroma of the pancreas. Clinical and clinical pathology examinations (lipase, alpha-amylase, glucose, CEA, CA 19-9 in serum) were inconspicuous. Chondroma of the pancreas does not require specific treatment.

Aged

Madura foot. A report of two cases.

Two cases of Madura foot which originated in the Middle East are described. This so-called maduramycosis is a chronic progressive infection caused by thread fungi or actinomycetes. The diagnosis is confirmed when the grains of mycetoplaits are demonstrated in the discharge from a sinus. Clinical findings and treatment are discussed. Medical treatment may be needed for several months, but operation is indicated for infections caused by the true fungi (eumycetoma).

Adult

[The dilemma of listeriosis control by the public health office].

The frequent occurrence of Listeria monocytogenes both superficially and in certain foods requires measures in accordance with the Federal Laws on Communicable Diseases and Safe Foods to study possible sources of the infectious agent and prevention if positive findings are reported. On the other hand, due to good defence mechanisms, the majority of the population are not at great risk. This excludes, however, immunodeficient patients, aged persons and newborn. The Federal Law on Notifiable Diseases requires only the reporting of meningitis and encephalitis as well as of listeriosis in newborn. Hence, Listeria infections with other syndromes are not registered. The some-times relatively long time of incubation and the lack of knowledge on mild and transient forms of listeriosis render the search for sources of such infections rather difficult. This results in a true dilemma. -Thus, it appears at the present to be more important to encourage strongly the producers of Listeria-endangered food, to eliminate the risk by all possible means. This, however, appears to be applicable only in a few food items. Therefore, the consumer should be more thoroughly informed, so that at least for the 'at risk' part of the population any possible danger may be minimised. Particular attention should be paid to impart good knowledge on the possibilities of preventing listeriosis by appropriately efficient methods of food preparation.

Food Microbiology

[Ultrasound controlled fine needle cytology and fine needle histology in circumscribed pancreatic processes].

Using a biopsy transducer 171 fine-needle punctures of focal pancreatic processes were done in 158 patients. The final diagnosis was made in the first group by surgical operation or autopsy, in the second by the further clinical course. The sensitivity of the cytological examination alone was 78% in the first group and 90% in the second. The histological examination alone had a sensitivity of 79% to 100%. Combining both ways of examination according to defined criteria the sensitivity in the first group was 84% and in the second 100%. The specificity was 100% for both. The complications were 2.9%. Of these 5 cases one pancreatitis had to be operated. There were no lethal complications. To optimize the sensitivity and specificity of the ultrasound guided fine needle puncture technique we want to recommend the following points: A biopsy transducer or puncture-aid must be available. The fine needle technique only should be done under the prerequisite of a high frequency of punctures and a high constancy in the relation between puncturer and pathologist. To receive representative material it can be necessary to make several needle passes during one session. Material for cytological und histological examination should always be taken simultaneously.

Adult

Papillary carcinoma of the prostate, location, morphology, and immunohistochemistry: the histogenesis and entity of so-called endometrioid carcinoma.

Fifty carcinomas that were partially to completely papillary in nature were examined. According to urethroscopic and rectal palpation findings, six of the carcinomas were located centrally, 40 tumors were in the prostate proper, and four were clinical stage T0. The epithelium of the papillary portions of the tumors was dark in some instances, light in others. Immunohistochemistry revealed that 20 of 22 tumors were positive for prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA). In no case was a topical relationship to the utriculus prostaticus demonstrable. The epithelium of the utriculus in seven additional patients who were not involved in this series also stained positively for PAP and PSA. Usual carcinomas of the prostate proper can develop endometrioid structures that do not differ immunohistochemically from ordinary portions of the carcinoma. Tumors located in central portions of the prostate are, in our opinion, morphologic variants of usual prostatic carcinomas, and apparently arise in prostatic ducts. We conclude that a distinction between endometrioid carcinomas and tumors of prostatic ducts does not seem justified and that papillary prostatic carcinomas should be treated like common prostatic cancer.

Acid Phosphatase

[Intrauterine volvulus with complete bowel necrosis and formation of a pseudo-cyst].

The article reports on a male newborn who attained an age of one day only. An intrauterine volvulus resulted in complete necrosis of the ileum with subsequent intrauterine development of a pseudocyst and corresponding structural changes in the abdominal wall. Clinically and on postmortem examination a highly inflated abdomen was particularly remarkable. The diaphragm was displaced upwards to an extremely high degree. The cause may be attributed to a disturbed development of the mesenterium, since other possible causes could be excluded. This case is compared with reports in the literature on this rare phenomenon.

Cysts

Problems of differential diagnosis of blastomyces and Russell bodies.

The European dermato-histologist is only rarely confronted with the diagnosis of granulomatous and systemic mycosis. The proper identification in sections and smears of blastomycetes of systemic importance is rather problematic, as Russell bodies may simulate fungi in certain stains. An own observation is reported with particular emphasis on differential diagnosis.

Blastomyces

[Candida in feces].

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Candida albicans

Tumoral calcinosis. Observations during six years.

Findings of a 56 year old woman suffering from tumoral calcinosis, who was treated for 6 years, are presented. Under conditions known to lead to negative calcium-phosphorus balance, a reduction in tumor size was seen. Transient hypercalcemia was attributed to immobilization. The process of tumor reduction was not definitely accelerated by treatment with ethane-hydroxy-diphosphonate (EHDP; 500 mg/day for 20 months). Nephrotic syndrome as a consequence of amyloidosis developed. Amyloidosis seems to have resulted from the aseptic histiocytic inflammatory process in the tumors. The possible importance of high cholesterol in very low density lipoproteins in the serum of the patient is discussed.

Amyloidosis