Biomedical subjects

H Sensing

Publications and source records attributed to H Sensing.

At least 19 recordsLinked to original sources

PubMed1991

[Studies on diagnostic and prognostic validity of aminophenazone breath test in liver cirrhosis].

In 59 patients with liver cirrhosis (23 female, 36 male; aged between 30 and 73 years) the aminophenazone breath-test according to the Haustein-Schenker modification was performed. The results were related to morphological, clinical and haemodynamic criteria. In contrast to a control group, consisting of 8 women and 8 men aged between 23 and 27 years with healthy livers, the aminophenazone elimination proved to be heavily delayed (p less than 0.001). In consideration of the Havanna-classification the 14CO2-elimination was most heavily retarded in patients with portal cirrhosis, but compared with non-portal cirrhosis, the difference was below significance level. A significant dependence on the clinical degree of severity was found. The aminophenazone-elimination was frequently low in portal hypertension and considerably decreased after portocaval shunt with values below 200 DPM/mmol CO2/70 kg body weight. In some cases it could be demonstrated, that the test is not only of diagnostic relevance, but reflects the progression of cirrhosis.

Adult↗

PubMed1991

[Influence of exogenous factors on the behavior of aminophenazone breath test in chronic liver diseases].

230 patients with different chronic liver diseases of various severity were researched because of the influence of nicotine and alcohol on the results of the aminopyrine breath test in the modification of Haustein and Schenker (1985). Smoker with chronic liver diseases had higher 14CO2-results than nonsmoker. The difference was only significant in fatty liver disease in the first stadium (p less than 0,001) and chronic active hepatitis (p less than 0.05). Patients with chronic liver diseases of fewer severity had higher mean values of aminopyrine breath test, if they had chronic alcohol consumption. The difference between these and abstinent patients could secure only in fatty liver disease in the first stadium (p less than 0.001). Patients with severe chronic liver diseases had lower results of aminopyrine breath test, if they drink alcohol regular. These difference was significant in patients with cirrhotic liver disease (p less than 0.05).

Adult↗

PubMed1991

[The diagnostic value of the aminophenazone breath test in chronic liver diseases].

In 230 patients (90 females, 140 males aged between 20 and 73 years, average age 47.8 years) with and without exception histologically and/or laparoscopically ascertained chronic liver diseases (degenerative damages of liver parenchyma in 45, fatty liver stage I in 28, fatty liver stage II in 36, cholangiohepatitis in 4, chronic persisting hepatitis in 31, chronic active hepatitis in 57 and liver cirrhosis in 59 cases) the incorporation of the aminophenazon breathing test in the so-called laboratory chemical liver spectrum was controlled. The restriction of the microsomal biotransformation established by means of the aminophenazon breathing test behaved parallel to the degree of severity of the disease. The aminophenazon breathing test was performed in the modification after Haustein and Schenker (1985). The largest delays in the decomposition were found in the complete cirrhotic transformation of the liver. The unequivocally pathologic result of the aminophenazon breathing test in severe irreversible damages of the liver parenchyma was confirmed by the formation of correlations with parameters of the conventional laboratory spectrum of the liver. Thus the restriction of the performance of the synthesis of the liver for coagulation factors and albumins was parallel to the loss of function of the mixed functional oxidases. In all patients with chronic liver diseases a connection between the value of the thromboplastin time (Quick's test) and result of the breathing test was found. Positive linear correlation between serum albumin and results of the breathing test could also be proved particularly in the group of the severe chronic inflammatory liver diseases. In chronic fibrosing liver diseases there were positive inverse correlations between gamma-globulin concentration in the serum and thymol turbidity test on the one hand as well as the aminophenazon breathing test on the other. There were no correlations between liver enzyme and aminophenazon breathing test. The results of the own investigations incorporate the aminophenazon breathing test as indicator of a severe liver cell damage which at the same time is established by the pathological result of the so-called synthesis parameters of the liver.

Adult↗

PubMed1988

[Behavior of the aminophenazone breath test in chronic liver diseases].

In 230 patients with histologically ascertained chronic hepathopathies the aminophenazone breathing test in the modification after Haustein and Schenker was carried out. In contrast to a control group consisting of 16 test persons with healthy liver (14CO2 exhalation 1019 +/- 175 DPM/mmol-CO2/70 kg body weight) the hepatic elimination of the [14C]-aminophenazone in chronic liver diseases (626 +/- 203 DPM/mmol CO2/70 kg body weight) was significantly restricted (p less than 0.001). The values of the aminophenazone breathing test showed a dependence on the degree of severity of the liver disease. Hepatoses with partly questionable or slight value of the disease did not differ in their results (841 +/- 230 DPM/mmol CO2/70 kg body weight) from those of persons with healthy liver. Chronic inflammatory liver diseases (668 +/- 185 DPM/mmol CO2/70 kg body weight) occupied an average position (p less than 0.001). The lowest values were to be seen in patients with chronic fibrosing liver diseases, mainly with liver cirrhosis (403 +/- 218 DPM/mmol CO2/70 kg body weight). Compared with the control group the difference was significant (p less than 0.001). Broad regions of overlapping of the individual values of various chronic liver diseases do not allow an unequivocal coordination of regions of the breathing test values to certain morphologically defined chronic hepatopathies. For the determination of size and degree of severity of the damage of liver parenchyma the aminophenazone breathing test, however, may be a valuable help in the framework of a special programme of diagnostics.

Adult↗

PubMed1987

Elimination of 16-acetyl-gitoxin in patients suffering from impaired liver function.

In ten patients suffering from moderate to severe disturbances of liver function (hepatic cirrhosis, carcinomatous metastases of the liver) the elimination of 16-acetyl-gitoxin from plasma was measured after a single oral dose of 1.2 mg pengitoxin. In 9 of 10 patients the mean half-life amounted to 67.3 h (SD 14.2 h). In one patient with carcinomatous infiltration of the liver and concomitant cirrhosis, the half-life was prolonged to 165.3 h. The results point to an unchanged elimination of 16-acetyl-gitoxin in patients suffering from liver cirrhosis.

Acetyldigoxins↗

PubMed1984

[Behavior of conjugated bile acids in chronic liver disease].

In 24 persons with healthy liver and 44 patients with chronic hepatopathies of different degree of severity (23 women and 16 men with chronic active hepatitis as well as 4 women and 1 man with unspecific degenerative damage of the liver parenchyma) in the C-bile conjugated bile acids were qualitatively differentiated. In contrast to persons with healthy liver in chronic hepatopathies apart from conjugated bile acids free bile acids appeared. The conjugation of the bile acids with taurine was proved in greater frequency than the glycine conjugation. Parallel to the degree of severity of the hepatopathy particularly the proportion of the taurine-conjugated dihydroxycholan acids increased, among which the tauro-chenodesoxycholic acid prevailed. The conjugation of the bile acids with glycine also in chronic hepatopathies remained longest in the fraction of the trihydroxycholan acids. The examinations show that the qualitative proof of the conjugated bile acids in the bile gives an additional information for the diagnostic estimation of the chronic hepatopathies.

Adult↗

PubMed1983

[Hepatic clearance of aminopyrine in the evaluation of liver function in hormonal contraception].

The function of microsomal destructing medicaments enzyme systems of the liver cell under hormonal contraception was objectified with the help of the aminopyrine test. After the oral administration of 9 mg dimethylaminoantipyrine (DMAAP) per kg body-weight together with 111 kBq 14C-DMAAP the elimination of 14CO2 was measured on the basis of the decrease of the radioactivity in the expiration air (respiration test). The plasma levels of DMAAP and its metabolites were measured, too. The two measurements lasted 5 hours. In contrast to a control group consisting of 8 women with healthy liver who were not ovulostatically treated (half-value time 14CO2-DMAAP 2.9 +/- 0.8 h, plasma 2.2 +/- 0.5 h) in 20 test women with healthy liver under ovulation inhibitors the elimination of 14CO2-DMAAP with 4.7 +/- 1.6 was clearly (alpha less than 0.01), the plasma elimination with 3.0 +/- 0.8 h was slightly retarded (alpha less than 0.05). In 19 patients with histologically ascertained chronic hepatopathies of above all insignificant degree of severity (13 degenerative lesions of liver parenchyma, 3 fatty livers stage I or II, 1 chronic active hepatitis each, chronic persisting hepatitis and cirrhosis) under hormonal contraception a half-value time of the 14CO2 elimination (alpha less than 0.001) prolonged to 5.0 +/- 1.5 h and a prolongation of the plasma elimination to 3.8 +/- (alpha less than 0.05). In 9 women in double examinations the 14CO2 elimination of the DMAAP after discontinuation of the application of ovulation inhibitors was compared with the values obtained under hormonal contraception and a regression of the retarded excretion in the expiration air (4.2 +/- 2.3 less than 5.1 +/- 1.2 h) and plasma (2.6 +/- 0.7 less than 3.4 +/- 1.7) was proved.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1983

[Clinical and prognostic significance of degenerative liver parenchyma damage].

Starting from the question, whether the morphological substrate of the degenerative damage of the liver parenchyma possesses an adequate clinical and prognostic valency 127 patients with histologically ascertained findings underwent a secondary examination over a period from 1 to 8 years (average 4 years). In two thirds of the patients the occurrence of a virus hepatitis in the anamnesis was conspicuous so that the suggestion of causal connections is obvious. An important clinical symptom of the degenerative damage of the liver parenchyma represent the findings of a hepatomegaly in the majority of the patients. Only in pathological results the laboratory-chemical parameters allowed diagnostic conclusions. Controls of the course, in which in 80 patients clinical and biochemical investigations as well as in 47 patients additional histological investigations of the liver were the basis, showed an involution in 48 patients (37.8%). 58 cases (45.7%) had a constant course of the disease. In 21 patients (16.5%) the degenerative damage of the liver parenchyma showed a processing tendency. Most patients with morphologically ascertained progressing courses of the disease gave anamnestic and/or histological references to a virus hepatitis gone through. The morphological substrate of the degenerative damage of the liver parenchyma partly by all means a value of a disease is to be ascribed to. The possibility of a transition stage to a defined chronic hepatopathy which is not to be excluded in several cases renders controls of the course necessary.

Adolescent↗

PubMed1983

[Diagnostic value of bile acids for determining the activity of chronic hepatitis].

Examinations of 39 patients with histologically ascertained chronic active hepatitis showed that from the behaviour of the bile acids in the C-bile may be concluded to the degree of severity and size of the inflammatory activity of the chronic liver disease. The total unconjugated bile acids were reduced in dependence upon the degree of the biochemical and/or histological activity of chronic hepatitis. The concentrations of the total bile acids decreased the more, the more distinct was the inflammatory activity. The increase of the biochemical and/or histological activity was characterized also by a reduction of the ratio trihydroxy-/dihydroxy-bile acids. From the alteration of the ratio causal relationships between the activity of the chronic hepatitis and the predominance of the chenodesoxycholic acid could be derived. This disease-specific behaviour of the bile acids which had diagnostic value for the demarcation of the stage of the disease of chronic hepatitis was statistically ascertained by the correlation calculation and the factor analysis.

Alanine Transaminase↗

PubMed1982

[Evaluation of liver function in chronic liver diseases using the bile acid spectrum].

In 24 persons with healthy liver and 44 patients with without exception morphologically ascertained chronic hepatopathies of different degree of severity the diagnostic valency of the bile acids was tested. In these cases the bile acids estimated in the C-bile proved as sensitive indicators of a chronic lesion of the liver parenchyma. Quantitative deviations of the bile acids, the relation from tri- to dihydroxycholan acids, qualitative alterations in the spectre of the free bile acids as well as changes of the form of conjugation were of importance concerning the functional diagnosis. The concentration of bile acids decreased the more expressed was the chronic lesion of the liver parenchyma. Trihydroxycholan acids and dihydroxycholan acids variably participated in the reduction of the bile acids in different forms of chronic hepatopathies. From the change of the quotient tri- to dihydroxycholan acids causal connections between the degree of severity of the chronic hepatopathy and the dominance of the chenodesoxycholic acid could be derived. Moreover, the conjugation of the bile acids with glycine prevailing in chronic hepatopathies underwent a degradated change. From the examinations results that quantitative and qualitative deviations of the bile acid spectre under defined morphological prerequisites render possible a differentiated judgment of the liver function in chronic hepatopathies.

Adult↗

PubMed1982

The determination of aminopyrin elimination for control of the metabolic capacity of the liver in man.

The kinetics of plasma and breath elimination of aminopyrine after 14C-aminopyrine given orally were studied using an open one-compartment model and first order rates of elimination. The study comprised eight healthy volunteers and two groups with histologically verified chronic liver diseases (cirrhosis, n = 12, and chronic aggressive hepatitis, n = 12). Elimination rates from plasma and breath were significantly reduced in the group with cirrhosis, but only so in chronic aggressive hepatitis when they were expressed relative to each other. Monomethylaminopyrine was eliminated more rapidly compared to aminopyrine, and the rate of formaldehyde formation was positively correlated to the excretion rate of CO2 (r = 0.53, P less than 0.002). No correlation was found with clinical or other laboratory data in the groups of liver diseases studied. The test is a quantitative indicator of the drug metabolizing mixed function oxidases of the endoplasmatic reticulum of the liver, and may reflect the degree of damage to this system in chronic liver disease.

Adult↗

PubMed1976