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H Shibayama

Publications and source records attributed to H Shibayama.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Three cases of Torsades de pointes].

Torsades de Pointes is an atypical ventricular tachycardia, a characteristic sinusoidal twisting of QRS complex around the base line, first described by Dessertenne et al in 1966. Since their original description, many literatures including both reviews and case reports have been issued. However, the exact causes, mechanism and its true relation to usual ventricular tachycardia and fibrillation remain to be elucidated. In the present report, three cases of Torsades de Pointes (TDP) were described. All these patients revealed a prolonged QT and QTc interval as has been recognized at the occasion of TDP attacks together with low serum potassium concentration. In addition, one had hypertrophic cardiomyopathy (case 1), cholelithiasis (case 2) and uterus cancer (case 3), respectively. Regarding to the treatment, direct current counter shock was applied to terminate the TDP in all 3 cases, the correction of low serum potassium concentration was also done in each case. Lidocaine was ineffective in case 3 to terminate the TDP, while verapamil was effective in case 3 to convert TDP to normal sinus rhythm. In case 2, no antiarrhythmic drugs were applied, however, cardiac massage and normalization of serum potassium concentration succeeded to recover normal sinus rhythm. The diversity of the causes and treatments of TDP in these three cases was discussed in relation to the genesis of TDP.

Adult↗
PubMed1986

Unusual cases of presenile dementia with Fahr's syndrome.

Three patients with an unusual type of presenile dementia were studied. Atypical clinical pictures emerged from an evaluation of these cases. Their symptoms and signs were thought to be neither those of Alzheimer's disease nor those of Pick's disease but a partial mixture of those of both diseases. The neuropathological changes were characteristic and the common findings were as as follows: the absence of senile plaques, the widespread presence of numerous neurofibrillary tangles, a calcareous deposition of Fahr's type, a circumscribed cerebral atrophy in the temporal or/and frontal lobes, a moderate or severe demyelination and fibrous gliosis in the white matter of the atrophied areas, and a slight or moderate neuronal loss in the nucleus basalis of Meynert. Similar cases reported previously were reviewed.

Brain Diseases↗
PubMed1986

Prevalence of dementia in a Japanese elderly population.

The geriatric community study was conducted by the Aichi Prefecture (Japan) Project. The psychiatric epidemiological survey was conducted using a stratified random sampling method. 3106 community residents over the age of 65 years, randomly selected from the whole Aichi Prefecture of Japan, were interviewed; 476 had suspected dementia. The second interviews and the neurologic examinations were carried out by psychiatrists. The prevalence of dementia was estimated to be 5.8% (moderate and severe, 2.2%; mild 3.6%) of the aged population in the community. Cerebrovascular dementia (CVD) or multi-infarct dementia (MID) was found in 2.8%, senile dementia of the Alzheimer type (SDAT) in 2.4%, and dementia due to other causes in 0.6%. CVD (MID) was diagnosed more frequently in men, and SDAT in women.

Aged↗
PubMed1983

An unusual case of Pick's disease.

A man aged 64, with a history of chronic trichloroethylene intoxication, presented early headache, impairment of memory, and "stehende Redensarten", later on mental deterioration with muteness and oral tendency. He died of bronchopneumonia. The brain was studied by light and electron microscopy. Numerous inflated cells, intraneuronal argentophil Pick bodies and central chromatolysis of neurons were found throughout the cerebral cortex. Widespread diffuse fibrillary gliosis was the finding bearing a striking resemblance to "progressive subcortical gliosis". Severe loss of nerve cells was observed in the temporal lobe (except the posterior of T 1) and moderate or mild loss in the gyrus rectus, insula, gyrus cinguli, and partial areas of the frontal, parietal, and occipital lobes. By electron microscopy, the argentophil Pick bodies consisted of a conglomeration of randomly arranged short 100-150 A filaments, ribosomes, vesicles, mitochondria, and scanty paired helical filaments. The present case was considered to represent a rare case of Pick's disease of the temporo-fronto-parieto-occipital type or panencephalic type.

Brain↗
PubMed1980

Characteristics of well-trained athletes in prolonged exercise from the viewpoint of aerobic power.

Aerobic power in prolonged exercise is related with the capability to continue exercise of an intensity corresponding to a fairly high percentage of V02 max besides the amount of V02 max itself. In the present study, the authors were led to the conclusion that the well-trained had excellent capability as regards physical resources and high adaptability to exercise and, accordingly, they showed more rapid acceleration of physiological functions than the untrained and could maintain high efficiency for oxygen supply through the whole course of exercise. Moreover, the increase in blood sugar content during exercise was marked in the trained, although exercise was considered to augment the uptake and consumption of sugar, but the increase in lactate content was comparatively small and that in serum FFA content was also rather low. Although the relative physiological work load seemed to be similar in both trained and untrained, the level of oxygen intake and the blood content during exercise were distinctly higher in the trained than in the untrained. These findings seemed to suggest the excellent aerobic power in the trained was helpful in augmentation of sugar oxidation.

Adult↗
PubMed1978

Electron microscopic structure of the Alzheimer's neurofibrillary changes in case of atypical senile dementia.

A man aged 70, showed early disorientation, memory defects, delusions and rages at 66, later mental deterioration with muteness and dysphagia. He died of cardiac failure. The postmortem examination revealed macroscopically and light microscopically the neuropathological findings of atypical senile dementia. Moreover, it is the interesting characteristic in the presented case that there are electron microscopically two types of filaments making the neurofibrillary tangles. One showed the so-called "paired helical filaments", which were observed in the cerebral cortex. The other showed paralled "straight filaments". These "straight filaments" were found in the bilateral hippocampi.

Aged↗
PubMed1978

An autopsy case of atypical senile dementia with atrophy of the temporal lobes--a clinical and histopathological report.

A man aged 70, descendant of an apparently healthy family, showed disorientation, delusional ideas and rages at 66. Later there was slowly advancing deterioration with muteness, disorientation and dysphagia. He died of cardiac failure. There was the diffuse atrophy of the cerebrum, which was remarkably accentuated on both temporal lobes (poles, T2 and T3), where the loss of nerve cells and proliferation of astrocytes were found in the cortex and pallor and conspicuous fibrillary gliosis were noted in the white matter. These findings fundamentally suggest Pick's disease. On the one hand, numerous senile plaques and Alzheimer's neurofibrillary changes, suggestive of Alzheimer's disease (senile dementia), were observed throughout the cerebral cortex. On the other hand, a few inflated cells were also seen in the cingulate, superior frontal gyri and temporal lobes. Basilar artery was moderately atherosclerotic and cerebrovascular disorders were distributed throughout the cerebral cortex and basal ganglia, especially in the field of supply of middle cerebral artery. This case is similar to rare cases reported by Berlin (1949), Neumann (1949) and Oyanagi et al. (1975). The nosological situation as a disease entity remains to be determined.

Aged↗
PubMedDate not supplied

Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: a comparison with Alzheimer disease.

Diffuse neurofibrillary tangles with calcification (DNTC) is an atypical dementia and is characterized pathologically by diffuse neurofibrillary tangles (NFTs) without senile plaques (SPs). In this study, we investigated the distribution of human leukocyte antigen (HLA)-DR-positive activated microglia in postmortem brain tissue of six patients with DNTC and six patients with Alzheimer disease (AD). HLA-DR-positive activated microglia were observed to associate with SPs in AD. In the DNTC brain, which lacks SPs, HLA-DR-positive microglia were mainly accumulated around weakly tau-positive NFTs, which were also positive for anti-amyloid-P and anti-C3d antibodies. The results of this study suggest that the complement pathway is also activated in the DNTC brain and that immune and inflammatory responses, including microglia activation, may occur around extracellular NFTs in DNTC patients.

Aged↗