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H Shimojo

Publications and source records attributed to H Shimojo.

107 records · Page 6Linked to original sources
PubMed1971

Inactivation of T antigen-forming capacites of simian virus 40 and adenovirus 12 by ultraviolet irradiation.

Methods to measure T antigen-forming capacities of simian virus 40 (SV40) and adenovirus 12 (Ad12) were investigated, and a method to measure the capacity in terms of T antigen-forming units was employed by the use of cytosine arabinoside. Plaque-forming units and T antigen-forming units of SV40, SV40 deoxyribonucleic acid, or Ad12 were inactivated by ultraviolet (UV) irradiation at the same rate, roughly following a single-hit curve. T-antigen formation by UV-irradiated SV40 and Ad12 was enhanced in cells multiply infected and in cells in a growing state. These observations showed that it was difficult or impossible to estimate the size of the gene for T antigen by UV inactivation.

Adenoviridae↗
PubMedDate not supplied

Poliomyelitis control in Japan.

The Sabin oral poliovirus vaccine ( OPV ) has been used in Japan since 1961. Since then the number of paralytic cases has decreased markedly. The incidence of paralytic and positive rates for antibodies to poliovirus were analyzed. The number of paralytic cases associated with OPV was low for cases due to type 1 virus and high for those due to type 2 virus. As for cases due to type 3 virus, the number was high until 1969 and has been low since 1970. This difference was brought about by changing the batch of type 3 virus used in the preparation of OPV . The analysis of titers of neutralizing antibody showed that response to type 1 virus in OPV used in 1977 and to type 3 virus in OPV used in 1972 and 1973 was not adequate. Both situations were improved by changing the batches of virus used for OPV . These experiences suggest that the use of good batches is necessary for safety and efficacy of OPV .

Antibodies, Viral↗