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Biomedical subjects

H Shiozu

Publications and source records attributed to H Shiozu.

13 recordsLinked to original sources

[An unusual autopsy case of corticobasal degeneration--with special reference to clinicopathological differentiation from progressive supranuclear palsy and slowly progressive aphasia].

We report an unusual autopsy case of corticobasal degeneration. The patient was male who was 67 years old at the time of his death. He developed clumsiness of his right hand at age 65. Neurological examination at age 66 revealed supranuclear ophthalmoplegia of upward gaze and parkinsonism. Progressive supranuclear palsy was suspected. The patient's clinical course was rapidly progressive. Dementia developed nine months after the onset of the disease, and the patient manifested apallic syndrome at 21 months and died of pneumonia at about 25 months. At autopsy the brain weighed 1370g. Macroscopic examination revealed prominent atrophy of the anterior and parietal lobes, particularly of the pars opercularis in the left inferior frontal gyrus, and there was marked depigmentation of the substantia nigra. Histological examination showed neuronal loss, glial proliferation, spongy state, and ballooned neurons in the frontal and parietal lobes. Neuronal loss with glial proliferation was conspicuous in the striatum, pallidum, thalamus, and substantia nigra. There was slight neuronal loss in the dentate nucleus and locus ceruleus. Staining by Gallyas-Braak method revealed massive appearance of argyrophilic threads. This case is important in terms of the clinical differentiation from progressive supranuclear palsy, and is also interesting in regard to the pathological correlation with slowly progressive aphasia.

Aged↗

[Myopericarditis].

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Diagnosis, Differential↗

Pseudoaneurysm of the distal aortic arch in Behçet's disease--a case report.

Behçet's disease, manifested as a triform of relapsing iritis, stomatitis and genital ulceration, is now recognized as a systemic vasculitis that affects both veins and arteries. However, aneurysms of the aortic arch associated with Behçet's disease are extremely rare. We report on a successfully resected pseudoaneurysm of the distal aortic arch in a patient with Behçet's disease. The aneurysm was evaluated preoperatively by computed tomography (CT), magnetic resonance imaging (MRI) and intravenous digital subtraction angiography (DSA). We found that these non-invasive methods were quite useful for diagnosing the aneurysm in the aortic arch. Aneurysms enlarge rapidly when coupled with infection and are prone to rupture, thus requiring extensive surgical repair. However, since false aneurysm formations often occur at the site of anastomosis, postoperative follow-up should be monitored very closely.

Adult↗

[Management of infected transvenous permanent pacemakers].

Between November, 1980, and January 1991, a total of 115 transvenous pacemakers were implanted in 102 patients at our hospital. Infection at the site of implantation developed in three cases or 2.6%. The median time of the onset of infection postoperatively was eleven and a half months, the range being two and a half to twenty-four months. Coagulase positive Staphylococcus aureus was cultured from the infected site of one patient and coagulase negative Staphylococcus epidermidis and saprophyticus in two patients. Staphylococcus aureus septicemia developed in one patient. Conservative medical treatment consisting of the application of two or more antibiotics was unsuccessful in all three cases. In two patients, removal of the infected pacemaker generator and implantation of a completely new pacemaker system at a new, clean site were conducted. In one of these two patients, the septic pacemaker electrode was withdrawn 3 months after removal of the infected pacemaker generator. In the other patient, limited thoracotomy with incision of the left brachiocephalic vein was performed for removal of the electrode three weeks after removal of the infected pacemaker generator.

Adult↗

Increased plasma cyclic nucleotide concentrations in congestive heart failure.

Plasma concentrations of cyclic nucleotides (adenosine monophosphate (AMP) and guanosine monophosphate (GMP) were measured by an ultrasensitive radioimmunoassay in 138 patients with heart failure due to various causes. Measurements were related to the New York Heart Association classification of symptoms, plasma noradrenaline concentrations, and mean pulmonary artery pressures. Serial concentrations of cyclic AMP and GMP were also measured daily in four patients treated for acute left ventricular failure. Plasma concentrations of cycle AMP were related to the severity of the heart failure, plasma noradrenaline concentrations, and pulmonary artery pressures. Cyclic AMP concentrations fell rapidly after treatment of acute left ventricular failure. Plasma concentrations of cyclic GMP also depended on the severity of heart failure and the pulmonary artery pressure, and decreased sharply with treatment although remaining at a high value. The cyclic GMP concentrations were significantly higher in patients with mitral stenosis than in those with other types of heart failure.

Adult↗

Effects of exogenous prostaglandin E1 on human plasma norepinephrine level and dopamine-beta-hydrolyxase activity.

Effects of exogenous PG E1 on the level of human plasma norepinephrine (NE), dopamine-beta-hydroxylase (DBH) activity, cAMP, cGMP, free fatty acids (FFA) as well as pulse rate and blood pressure were studied. Significant decreases of blood pressure and increases of pulse rate were observed after 20 min of the infusion of 0.05 microgram/kg/min of PG E1. The level of plasma NE increased by 174% (p less than 0.005) after the infusion. However, the increase of DBH activity was not significant. There was a tendency of increase of plasma level of FFA. These results suggested that the infusion of PG E1 caused an augmented sympathetic nervous activity due to systemic hypotension induced by PG E1.

Blood Pressure↗

Pseudocoarctation of the aorta--a case report.

We report a case of a 43-year-old woman with pseudocoarctation of the aorta manifested by a superior mediastinal mass on the chest roentgenogram. Evaluation was made using computed tomography (CT), magnetic resonance imaging (MRI) and digital subtraction angiography (DSA). No other congenital anomalies or aneurysms below the kinked area of the aorta could be found. The characteristic "kink" of the aorta and the absence of true coarctation were evident in the sagittal plane by MRI. MRI is of great value for examining disorders of the aorta.

Adult↗

Dopamine-beta-hydroxylase activity after acute myocardial infarction.

After acute myocardial infarction, serial serum dopamine-beta-hydroxylase (DBH) activity was elevated in both high and low DBH subgroups. The observed increase in DBH activity on the first, second, and third days after acute myocardial infarction suggests an augmentation in sympathetic nervous system activity after acute myocardial infarction.

Acute Disease↗