Biomedical subjects
Publications and source records attributed to H Smet.
Apparent sustained lid lag appears to be a peculiar neuro-ophthalmologic finding in Guillain-Barré-Strohl syndrome. We propose that the sign occurs with peripheral facial paralysis and it results after attempted forced lid closure, rather than being of central origin.
Certain patients with reduction or loss of central visual function and/or hemianopic changes of the visual field can be classified as well-informed malingerers, individuals who are easily influenced by suggestion, or neurotics suffering from "conversion hysteria." The main symptom is one of a functional sensory change (loss or reduction of visual field). The task falling to the ophthalmologist is to prove the contrary, using certain subjective and objective tests to prove the incompatibility of the results with the physiological facts. The authors discuss the specificity of these tests in this context and present a number of cases with the characteristic temporal or nasal functional hemianopsia comparing them with patients who have hemianopsias due to real anatomic lesions.
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A novel myotropic peptide was isolated from an extract of 10,000 heads of adult Leptinotarsa decemlineata by means of high performance liquid chromatography (HPLC). The peptide stimulates the contractions of the oviduct of Leptinotarsa as well as that of Locusta migratoria. Gas phase sequencing and comparison of candidate synthetic peptides in the amide and acid form revealed the following primary structure: Ile-Ala-Tyr-Lys-Pro-Glu-NH2. This new peptide has a molecular weight of 720 Da and has been named Led OVM. Led OVM does not exhibit significant sequence homology with any known vertebrate or invertebrate peptide. Sixteen additional myotropic factors were also separated by means of HPLC, but were as yet not recovered in amounts large enough for them to be sequenced.
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