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Biomedical subjects

H Soeda

Publications and source records attributed to H Soeda.

At least 37 records · Page 2Linked to original sources
PubMed1990

Pharmacokinetics of diltiazem in patients with liver cirrhosis.

The pharmacokinetics of diltiazem (DTZ) was investigated in seven control subjects with normal liver function and in seven patients with liver cirrhosis. After long-term oral administration of diltiazem, 30 or 60 mg thrice daily, serum levels of DTZ and its active metabolites, deacetyl DTZ (DAD) and N-demethyl DTZ (DMD), were determined by high performance liquid chromatography. The mean peak serum concentrations (nmol/L) in control patients were 280 for DTZ, 58 for DAD and 101 for DMD. In cirrhotic patients, the serum DTZ tended to increase and the DAD increased (p less than 0.05), while the DMD decreased (p less than 0.05) compared with that of the control (335 for DTZ, 133 for DAD and 77 for DMD, nmol/L). Pharmacokinetic analysis using a one-compartment model revealed no change in the absorption, but a decrease in the elimination for cirrhotic patients (t 1/2; 5.3 to 7.2 h, p less than 0.1). The elimination rate constant correlated with some biochemical indices for hepatocyte function. These results may be explained by the impaired oxidative metabolism of diltiazem in liver cirrhosis.

Adult↗
PubMed1990

NaCl and water responses across the frog tongue epithelium in vitro.

Isolated dorsal epithelium of the frog tongue elicited transepithelial NaCl and water responses across the tissue when NaCl was added to or removed from the adapting Ringer solution in the mucosal surface, respectively. The NaCl response which was a negative polarization in the mucosa with respect to the serosa was associated with a decrease in resistance across the tissue, whereas the water response which was a positive polarization was associated with an increase in the resistance. The decrease and increase in the tissue resistance remained unchanged by various polarizations of the transepithelial potential difference across the tissue. Characteristics of the NaCl and water responses were similar in many respects to those in the taste cells and nerves of frogs. Thus the NaCl and water responses may relate to taste reception.

Animals↗
PubMed1990

Comparison of NaCl-induced response across the tongue epithelium to that across other epithelia in the frog.

Electrical properties of the frog tongue epithelium were compared to those of skin and bladder, which have active sodium transport. During perfusion with Ringer solution, the potential difference across the tongue epithelium was negligible, unlike those of the skin and bladder. NaCl stimulation of the tongue epithelium produced a response with a polarity opposite to that of the skin and bladder. The response profile of the tongue epithelium except for the polarity resembled that of other tissues. In conclusion, the NaCl response of the tongue epithelium is independent of active sodium transport and instead occurs by passive transport, which may influence taste reception.

Animals↗
PubMed1989

Electrical properties of salt induced response across the tongue epithelium in frogs.

Transepithelial response across frog tongue epithelium induced by NaCl was compared with that induced by other salts and saccharides. All responses to salts including NaCl were negative in the mucosa to the grounded serosa and were associated with decreased tissue resistance, whereas those to saccharides were positive with increased tissue resistance. The response to salts varied in pattern and magnitude with variation in stimulus quality. The results indicate that the salt induced response is mediated by cation movement through the tissue and is implicated in taste reception.

Animals↗
PubMed1988

Characteristics of the water response across the dorsal epithelium of frog tongue.

1. Dorsal epithelium of the frog tongue produced a change in potential difference across the tissue in response to removal of NaCl from the adapting Ringer solution on the mucosa. 2. The response was not caused by an osmotic decrease in the stimulus, and its profile was in many respects similar to that of the receptor potential in frog taste cells. 3. In conclusion, the response may influence or modify water reception in frogs.

Animals↗
PubMed1987

Sodium permeability of the frog tongue epithelium.

Application of NaCl to the frog tongue produced a sodium influx through the dorsal epithelium. The flux was distinctly faster through those of the palatal epithelium and the skin, and may influence taste reception in frogs.

Animals↗
PubMed1986

Electrical response to acid across the dorsal epithelium of the frog tongue.

Acid stimulation produced a change in trans-epithelial potential difference across isolated dorsal epithelium of frog tongue. The responses to acetic acid, tartaric acid and citric acid were significantly greater than those to hydrochloric acid and nitric acid at the same pH. Metabolic inhibitors had no effect on the response, but local anaesthetics reversibly depressed it. The induced response was associated with a decrease in tissue resistance. Positive polarization on the mucosa increased the response, which was decreased or reversed under negative polarization. These responses may be caused by diffusion of H-ions through the tissue, and may influence sour reception in the frog.

Acetates↗