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Biomedical subjects

H Spechtmeyer

Publications and source records attributed to H Spechtmeyer.

At least 19 recordsLinked to original sources
PubMed1982

[cis(Z)-Clopenthixol decanoate--a new depot neuroleptic].

cis(Z)-Clopenthixol decanoate is a new depot neuroleptic that belongs to the group of thioxanthenes. It has a duration of effect ranging from 2 to 4 weeks and it is used for long-term therapy of chronic schizophrenic patients. The aim of this review is to represent the chemistry, pharmacology, pharmacokinetics, dosage and efficacy of this drug. The target symptoms that essentially call for the application of cis(Z)-clopenthixol decanoate are hostility, suspiciousness and psychomotor restlessness. However, a distinct therapeutic effect has also been observed in patients with hallucinatory-disintegrative and manic syndromes. Moreover, the depot preparation also called forth an emotional stabilization among alcoholics as well as a mitigation of alcohol withdrawal symptoms.

Chemical Phenomena↗
PubMed1979

A mathematical model of thrombopoiesis in rats.

A mathematical model of thrombopoiesis in rats is presented. This has four compartments; stem cells, megakaryocytes, thrombocytes and thrombopoietin. A high thrombopoietin concentration influences bone marrow proliferation in three ways. Firstly the stem cells are stimulated and a slow increase in megakaryocyte number follows. Secondly there are additional endomitoses in the (early) megakaryocytes resulting in an increase in megakaryocyte volume. Thirdly the megakaryocyte maturation time is shortened. The parameters of the model are determined from experimental values for the normal, maximum and minimum proliferation rates, maturation times and destruction rates. The model is tested by comparing simulated results for acute and chronic thrombocytopenia and thrombocytosis with experimental curves from the literature. The model and data agree within the limits of experimental error. Not all of the thrombopoietic regulatory system is known yet, so some important alternative hypotheses are investigated and compared with the model. Several hypotheses have been excluded in this way.

Animals↗
PubMed1978

[Computer-assisted diagnosis of haematological disease in hospital patients (author's transl)].

A system of computer-assisted diagnosis is described which, in analogy to conventional diagnosis, takes into account both logical and statistical factors. The arrangement of such a system makes it clear that, after a period of successful use in specialist branches of medicine, a phase of less spectacular success has occurred which, however, provides the conditions for including larger areas of medicine in computer-assisted diagnosis. These systems are likely to conform more closely to the needs of the doctor than previous ones. Whether they can be used in non-hospital practice would depend largely on whether the questions put to the system by the doctor do not take more time and answers can be given in short, easily understandable form. The best type of answer as well as the transmission of information can be discovered empirically. The differential diagnostic level of computer-assisted diagnosis is, according to present experience, quite satisfactory but can be further improved. This development is greatly helped by continuing increases in the speed of calculators and their data storage capacity.

Diagnosis, Computer-Assisted↗
PubMed1975

[Data acquisition in clinical trials].

Methods of data acquisition in clinical trials are reviewed and their advantages and disadvantages are discussed. To avoid the effort of multiple data acquisition and to eliminate possible transcription errors the data of the patients should be collected and stored in a data bank only once also in case of a drug study. From the data bank the results can be used for the different clinical purposes as well as for the statistical evaluation when testing drugs.

Clinical Trials as Topic↗