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Biomedical subjects

H Sperschneider

Publications and source records attributed to H Sperschneider.

80 records · Page 5Linked to original sources
PubMed1980

Comparative in vitro investigations on the dialysability of hypnotic and psychotropic drugs by hemodialysis and controlled sequential ultradiffusion.

The efficiency of hemodialysis and controlled sequential ultradiffusion (CSU) for the elimination of toxic drug concentrations was tested by in vitro-investigations. In the 6 benzodiazepin derivatives tested, the clearance is markedly higher at a blood flow of 200 ml/min than at 100 ml/min. Pyrithyldione, glutethimide and phenobarbital are better dialysed than the benzodiazepines with exception of chlordiazepoxide. In comparison with hemodialysis, hemofiltration by means of CSU was less effective because of the small amount of ultrafiltrate obtained.

Anti-Anxiety Agents↗
PubMed1978

[Long-term treatment of glomerulonephritis with indomethacin with special regard to quantity and selectivity of proteinuria].

In 53 patients (19 women, 34 men), of them 41 patients with an intracapillary proliferative glomerulonephritis, 9 with membranous proliferative and 3 with a membranous glomerulonephritis under an indometacin therapy examinations concerning proteinuria were carried out, partly with determination of the index of selectivity and representation of the protein clearance. In patients with a moderate proteinuria of less than 3 g a day this treatment achieved a smaller antiproteinurie effect than in patients with a large proteinuria. When a large activity of the inflammatory process was present a therapeutic success was less frequently to be proved. An unequivocal correlation between the histological course of the disease and the change of the proteinuria could not be recognized. After cautious estimation of the findings the selectivity of the proteinuria may be regarded as a certain indicator for the application of indometacin. The protein clearance, however, proved less suitable for the judgment of the treatment performed.

Adolescent↗
PubMed1977

[Pathophysiology and therapy of anemia in chronic renal insufficiency].

During a chronic renal insufficiency obligatorily an anaemia develops, which shows a statistically highly significant non-linear correlation to the degree of the impairment of the renal function. The pathogenetic points of view are very diverse and include disturbances of the formation of erythrocytes and a shortened life span of the erythrocytes. The necessary treatment of anaemia, above all in patients on the chronic dialysis programmes must consider these pathomechanisms and will be in most cases identical with a polypragmasy.

Anemia↗