[VII. International Congress on Infections in Gynecology and Obstetrics 4-7 March 1992 in Munich].
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Biomedical subjects
Publications and source records attributed to H Spitzbart.
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Between 1981 and 1983 48 patients with an average age of 54 years have had an arterial embolization of internal iliac artery. In 7 patients this was done preoperatively within a clinical study, in 41 ones because of profuse vaginal bleedings. In 6 patients there was a vital indication. In all cases survival time was 152 days. In two cases a re-embolization was necessary. In these two patients survival time was on average 338 days. The manoeuvre was done with particles of gelatin of different size suspended in contrast medium. One complication could be observed, but was not caused directly by embolization. In cases of profuse or vital bleedings which conservatively cannot be stopped embolization is method of first choice with no contraindication.
We report about the therapy of Herpes simplex infections. We applied triapten ointment topically in 166 women with relapse illnesses. In cases with early application we cured 80 per cent of vulvitis herpetica. In 17 per cent we observed side effects we tried to clarify the reasons.
We examined 97 healthy and non-pregnant women aged between 17 and 58 years, who especially did not show any symptoms of vulvitis or colpitis, for the contents of cholesterol in serum and vaginal smear. In the vaginal smear we found significantly lower concentrations of total cholesterol as in serum, whereas the part of free cholesterol on total cholesterol in vaginal smear was triple than in serum and its absolutely concentration was double than that in serum. Possible reasons are discussed.
Flame photometric determinations of sodium, potassium, and calcium, moreover magnesium concentrations according to a complexometric method in 197 healthy nonpregnant women aged 16-46 years were performed in serum and fluid of the vagina. The concentrations of K+, Ca++, and Mg++ in vaginal fluid showed marked increase of some 5, 6, respectively 4 times from those of serum. The sodium concentration of the vaginal fluid is half of serum. The concentration of magnesium in vaginal fluid showed a significant increase of a quarter in comparison with serum after application of hormonal contraceptiva. The origin of vaginal fluid is discussed.
The vaginal flora was investigated in women with trichomoniasis by means of a culture method. Trichomonas, yeast-like fungi and various types of bacteria were isolated. The applied microbiological technique allowed isolation not only of aerobic and cicrophilic bacteria but only of anaerobic bacteria. Anaerobic bacteria were nonspore-forming and were isolated very frequently in the vagina.
We report about a patient who received different drugs because of a vaginal mycosis for two years. Development of deep vaginal mycosis had to be observed, which can be treated only systemically.
We have proved with screening-electron-microscopic examinations that different chemical substances bend to formation of cristals on the vaginal skin. Different size of the cristals depends from different quantities of the drugs. Cytotoxic appearances are possible.
Significance of KOH test and isonitril (isocyanide) reaction tested in 104 patients was compared with our microbial culture results. In Gardnerella vaginalis as well as in no spores forming anaerobic germs the KOH test was not and the isonitril reaction was only insignificant reliable. Both tests are not able to substitute the procedures of culturing germs including those of Mycoplasma hominis and Ureaplasma urealyticum.
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We report about the histo-microscopical and electro-microscopical examinations to clearing up the transudation and reresorption. It was made the trial about to explain, because we found appointed substances in high concentration in the fluid of the vagina.
The problem in the diagnosis and therapy of the vaginal mycosis is discussed. With help of the electron microscopic examination we found yeasts on the surface of the vagina and within the intra- and subepithelial reach. These explained with restriction the possibility for a rezidive.
This paper outlines the results of investigations about the germicidal behaviour of the protease containing substance Biozym. It has been noted, that a concentration of 2.5 per cent is satisfactory for a definite effect. Biozym shows no significant effect against yeast. By this reason it is possible to clean and to desinfect bacterial contaminated matters.
There is dealt with maternal mortality because of puerperal infections based on GDR-statistics. The expert opinions of special commissions dealing with struggle against maternal mortality are considered while analyzing the possibilities of infection. Necessary diagnostics and special individualized therapy are referred, too.
By means of thin layer chromatography amino acids, lipids and phospholipids were detected in the vaginal fluids of pregnant and nonpregnant women with and without vaginal yeast colonization. Though pregnancy and/or yeast colonization do not seem to alter qualitatively the spectrum of amino acids and lipids of the vaginal fluid, an influence is supposed of these substances - like that of glucose - on growth and metabolism of the yeasts and on the clinical manifestation of vaginal candidosis.