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Biomedical subjects

H Stöss

Publications and source records attributed to H Stöss.

70 records · Page 4Linked to original sources
PubMed1984

Intoxication following the inhalation of hydrogen fluoride.

The prognosis for fluoride inhalation is poor, owing to the extreme toxicity of the substance and lack of satisfactory treatment. In the case of massive inhalation, the slow, progressive destruction of the bronchial mucosa and lung tissue will be lethal. Irrespective of the dose, a transient restriction in renal function or acute renal failure will occur. The transient increase in transaminase seems to be caused by several factors. Our cases show that the evaluation of fluoride levels in biological material is difficult, as dietary intake, e.g., in drinking water, may complicate acute or chronic occupational exposure.

Adult↗
PubMed1983

Are bowing of long tubular bones and preaxial polydactyly signs of the Meckel syndrome?

We describe four cases with signs resembling those of Meckel syndrome. Two cases demonstrated postaxial polydactyly; one case, preaxial polydactyly; and one case, pre- and postaxial polydactyly. Since there is at least one other reported case with preaxial polydactyly, it may be a rare sign of the Meckel syndrome. In all four cases, various degrees of bowing of the long tubular bones were observed. Since at least two cases exhibited typical Meckel syndrome and since in a few further reported cases X-ray examination revealed bowing of long tubular bones, this sign is considered to be a further, hitherto not well recognized sign of the Meckel syndrome, and not grounds for delineation of a new syndrome. An extensive review of the literature revealed, that shortened and bowed extremities may be present in about one-sixth of all cases with Meckel syndrome.

Abnormalities, Multiple↗
PubMed1983

Progressive pseudorheumatoid arthritis of childhood (PPAC). A hereditary disorder simulating rheumatoid arthritis.

Five patients are described with a hereditary arthropathy affecting major and minor joints. The main features of this progressive connective tissue disorder are restricted joint mobility, osseous swelling of the interphalangeal and other joints, and platyspondyly. The condition is commonly misdiagnosed as "chronic juvenile polyarthritis with Scheuermann disease". It differs from the rheumatoid-factor-negative polyarticular form of rheumatoid arthritis and other rheumatoid spondylarthropathies by the absence of arthritic and other inflammatory changes, radiographically by the absence of destructive and the presence of dysplastic bone changes. The disorder does not seem to respond to the usual forms of antirheumatoid treatment. Histological studies showed a peculiar, nest-like clustering of chondrocytes in the resting and growth cartilage suggesting that pathogenetically this is a primary disorder of the articular cartilage.

Adolescent↗
PubMed1982

Wolcott-Rallison syndrome: diabetes mellitus and spondyloepiphyseal dysplasia.

In 1972, Wolcott and Rallison described three siblings with a combination of infancy-onset diabetes mellitus and multiple epiphyseal dysplasia. We have observed a brother and sister with the same disorder. The chondro-osseous lesions are those of a spondylo-epiphyseal dysplasia. The diabetes mellitus is relatively mild. Histologic and electron microscopic studies of chondro-osseous tissue show findings similar to those in other epiphyseal and spondylo-epiphyseal dysplasias. In addition, however, atypical collagen-like fibres are found inside and outside chondrocytes. Collagen production seems to be normal in cultured fibroblasts. From the available data it appears that the association of characteristic chondro-osseous and endocrine abnormalities is non-random and that the lesions are independent manifestations of a pleiotropic gene. We propose to call this disorder the Wolcott-Rallison Syndrome.

Biopsy↗
PubMed1979

[Treatment of osteogenesis imperfecta with (+)-catechin (author's transl)].

4 girls aged 4--12 years with various forms of osteogenesis imperfecta were treated with (+)-catechin for several months. Bone punch biopsies from the iliac crest were investigated by electron microscopy before and during treatment. The frequency of fractures decreased clinically. There were no radiographic changes in the bones and there were no side effects. Electron microsopy showed a dilated coarse endoplasmatic reticulum with infrequent ribosomes, thin collagen fibrils and decreased predominantly disseminated mineralisation before treatment. Under the influence of treatment electron microscopical aspects of the bone improved. The cisternae of the endoplasmatic reticulum were arranged parallel with densely packed ribosomes, collagen fibrils were wider and in closely packed bundles and mineralisation was clearly improved. The electron microscopic findings are evidence for a possibly beneficial influence of (+)-catechin in some cases of osteogenesis imperfecta.

Benzopyrans↗
PubMed1977

[Dura transplantation. Multi-sequential transplants of solvent dehydrated dura mater. Animal experiment studies on the question of sensitization].

After the excision of 7 X 5 mm abdominal muscle sections in an experiment using rats, a total of 4 xenogenic, solvent dehydrated dura mater of the same size were implanted at 4 week intervals each. The transplant areas were continuously examined under a light and electron microscope for a period ranging from 7 days up to 3 months after the last transplant. Spontaneous layers of absorbent granulation tissue, rich in cells and blood vessels, surrounded the grafts in the beginning. Subsequently the grafts were gradually decomposed from the periphery to the center through macrophages like biological foreign matter and replaced with endogenous, poorly vascularized, collagenous connective tissue. The tissue reaction to the multi-sequential, xenogenic grafts was consistently the same as after single transplants. Immuno-competent cells do not increase. The solvent preserved dura mater is suited for multisequential transplants due to lacking sensitization, i.e. immunological rejection reaction.

Animals↗
PubMed1977

[The solvent-dried dura mater. A new dura transplant in the animal experiment].

After the excision of 7 X 5 mm abdominal muscle sections in an experiment using rats, rehydrated, solvent dried dura grafts of the same size were implanted. After three hours the tissue reaction of the transplant areas were continuously examined under a light and electron microscope for 14 months. A gradual graft decomposition advancing in a coating form from the periphery to the center and a simultaneous replacement with collagenous connective tissue of the body resulted due to an absorbent granulation tissue rich in cells and blood vessels after the initial infiltration of neutrophil granular leukocytes caused by the operation. A fibrous-rich connective tissue plate, in part forming two layers and thereby serving as a reminder of the former dura graft is decomposed in the abdominal muscles of the rats without infection or rejection and replaced with endogenous connective tissue. The duration of this decomposition and transformation process is contingent on the size of the graft and the tissue reactivity in the surrounding transplant area.

Animals↗
PubMedDate not supplied

[Osteoma cutis, a case report from the orthopedic viewpoint].

Osteoma cutis is a benign cutaneous disease which causes a primary heterotopic ossification of the skin. Corresponding to the appearance it is possible to distinguish four modifications. The enlargement of osteoma cutis can disturb the function of joints and statics. The etiology of the disease is unknown. Hamartoma or metaplasia is subject of discussion. It is important to mark off osteoma cutis from pseudohypoparathyreoidism (Albright-syndrome++).

Adult↗