Biomedical subjects
Publications and source records attributed to H Steim.
Bioequivalence was estimated in 6 resp. 7 male volunteers for two combination drugs of phenylbutazone (Neuro-Elmedal, Sigma Elmedal) after intramuscular administration using a monopreparation as a standard. Plasma levels of phenylbutazone were assayed by high pressure liquid chromatography. With respect to rate and extent both combination drugs were identical to the mono drug.
The effect of the combination preparation Moducrin on the blood pressure in the course of the day, the heart rate and the routine blood parameters was investigated in 25 patients with essential hypertension. The blood pressure was shown to be completely stable in the daily profile and was almost equally high in standing and supine position. The electrolyte balance remained constant in all cases. Only the serum uric acid and the creatinine rose negligibly during the treatment. The studies have shown that in 80% of patients with essential hypertension a constant lowering of blood pressure throughout the day could be achieved with one tablet of Moducrin, without upsetting the electrolyte balance.
In 35 pregnant women threatening premature labour and cervic dilatation indicated therapy by a beta-mimetic compound (fenoterol) for tocolysis. 17 patients (group I) got fenoterol-monotherapy; in 18 patients (group II) fenoterol was combined with the cardioselective beta-1-blocking agent metoprolol. There were no differences in age, bodyweight and time of gestation in both groups before therapy; also the obstetric states--as compared by pelvic score (Bishop) and tocolysis index (Baumgarten)--were nearly identical. Efficiency of tocolytic therapy was evaluated by prolongation index (Richter) and tocolysis-success-score (Weidinger). Statistical analysis comparing these parameters in both groups showed no significant differences. Heartrate, however, was significantly (p > 0,005) lower in patients treated by fenoterol and metoprolol, thus indicating less cardial stress induced by fenoterol. In conclusion the combination of the semiselective beta-2-stimulating compound fenoterol with the beta-1-blocking agent metoprolol is proposed for tocolytic therapy because of less cardial stress but identical tocolytic efficiency as compared with fenoterol-monotherapy.
35 pregnant women were treated with the semiselective beta 2-stimulating compound fenoterol because of threatening premature labor. The efficiency of tocolysis and the cardiovascular effects of a mono-therapy with fenoterol were compared with a combined therapy with the beta 1-blocking compound metoprolol by the following parameters: Heart rate, systolic and diastolic blood pressure, left ventricular dimensions and mean Vcf as determined by echocardiography, pelvic score, tocolysis-index and tocolysis-success-score (Weidinger-score). Metoprolol caused a remarkable and highly significant reduction of the fenoterol-induced cardiac effects: increase of heart rate and augmentation of mean Vcf; the blood pressure was significantly lowered by metoprolol. The tocolytic effect of fenoterol in no respect was blunted by metoprolol.
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