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Biomedical subjects

H Steiner

Publications and source records attributed to H Steiner.

At least 37 records · Page 2Linked to original sources
PubMed1978

Ionic strength dependence of the oxidation of iodide and ferrocyanide by compound I of horseradish peroxidase.

The kinetics of the oxidation of iodide and ferrocyanide by compound I of horseradish peroxidase have been studied at 25 degrees C as a function of ionic strength and pH. The ionic strength dependencies of the second-order rate constants are tested with an extended form of the Debye-Hückel equation for the activity coefficients of the reacting species. For the reaction of iodide with compound I it is shown that the pH variation of the rate constant at zero ionic strength is caused mainly by titrating a catalytically important acid group and not mainly by the varying charge of the protein. The ferrocyanide reaction rate with compound I does not correlate with enzyme net charge, at all pH values. The influence of electrostatic interactions on reaction rates is discussed.

Ferrocyanides↗
PubMed1977

[Concordant medullary thyroid carcinoma in identical twins with discordant phaeochromocytoma (Sipple syndrome) (author's transl)].

The first case of Sipple syndrome in identical twins is reported. It is concluded that the concordant medullary carcinoma of the thyroid is the result of a germinal mutation, whilst the discordant solitary phaeochromocytoma is caused by a somatic mutation according to the two mutation model. The practical conclusion to be drawn from this report is that if one identical twin develops carcinoma of the thyroid or a phaeochromocytoma, the other twin should be throughly investigated and surgical exploration undertaken, even in the absence of clinical evidence of disease.

Adult↗
PubMed1977

[Treatment of anemia in pregnancy].

In a therapeutic comparative study two trial-groups (1 and 2) of 30 pregnant women each suffering from iron deficiency anemia of light degree received randomly selected a combination of ferrous succinate and multivitamins (Multibionta-Eisen) or a combination of ferrous sulfate and folic acid (preparations ES). By both medications the decrease of hemoglobin, red blood count and hematocrit could be stopped and a re-increase of these values was seen afterwards. There was no significant differences in response between Multibionta-Eisen and ES. A significant increase of Hb, RBC and Hc as compared prior to treatment was limited to group 2. Possible causes for the non-significant results of group 1 are discussed. The results of the study are demonstrating a certain superiority of preparation ME. This combination showed at least equal efficiency as preparation ES in spite of a smaller iron dosage and was well tolerated without exception. Subjective complaints may be better improved by Multibionta-Eisen.

Anemia, Hypochromic↗
PubMed1977

Survey of gastroenteritis in children admitted to hospital in Newcastle upon Tyne in 1971-5.

In a survey of 674 children admitted to the main gastroenteritis unit in Newcastle upon Tyne from 1971 to 1975 there was a noticeable reduction in the incidence of severe dehydration and hypernatraemia, though there was no appreciable change in many characteristics of the patients. This period coincided locally (and nationally) with a determined effort on the part of health visitors and doctors to encourage mothers to breast-feed and to advise them to avoid giving concentrated milk feeds and ensure an adequate water intake during febrile illnesses. This may have contributed towards a reduction in the severity of the illness in children with gastroenteritis admitted to hospital. The overall mortality and the incidence of neurological complications in cases of hypernatraemia are low compared with previous reports.

Breast Feeding↗
PubMed1977

Psychiatric complications of burned adults: a classification.

The psychiatric complications occurring in a group of adult burn patients were correlated with pertinent data in the literature and a classification constructed, based on the three stages of the acute grief response to injury: psychiatric complications occur when the process of mourning is arrested in a regressive episode. Thirty-five adult patients with burns of greater than 7% body surface area were studied. It was found that Body Surface Area burned, the presence of a Premorbid Psychiatric Diagnosis, and Age are all significantly correlated with the occurrence of psychiatric complications following burn injuries and account for 61% of the variance in the sample. The implications of these findings and possibilities for further research are discussed.

Adult↗
PubMed1977

An evaluation of child health clinic services in Newcastle upon Tyne during 1972-1974.

The community child health clinics continued to provide an important and popular service for mothers with young children in Newcastle during 1972-1974, supplementing the primary care services of general practitioners as only a minority of them had undertaken the preventive aspects of child care. Most of the work of the community clinics was done by health visitors and it consisted of advice, support, and reassurance about the everyday problems of children. Although an appreciable amount of the work of the community doctors was developmental screening (birthday checks) most mothers consulted them about relatively minor medical complaints--such as feeding difficulties, specific developmental problems, and immunisation. There was no attempt to do a birthday check on all the children in the city and those that were done revealed few significant undetected abnormalities because most of the children had already attended clinics. In a poor area of the city, family and social problems were often found but very little consultation took place between health and social services, indicating the need for better liaison between these services. The community child health clinics will need to be maintained if general practitioners cannot provide these services and are unable to include preventive as well as curative child care within their practice.

Child Health Services↗
PubMed1977

[Programmed labor: methods, results, guidelines (author's transl)].

The programming of labor (setting the best possbile time under optimal conditions) was carried out in the University Women's Hospital, Freiburg i. Br. between 1970 and 1975 in 1121 cases. No perinatal mortality was reported. The secondary frequency of cesarean section for this primarily uncomplicated labor was 3.21% (general hospital statistics for this time period: 6.29%). The most important factors for the strict standardized method of induction is the observation of the pelvic score (desired: greater than 6) and a moderate dose of oxytocin or prostaglandin based on the essential amniotomy. In a statistical comparison of three groups of patients (n = 786): programmed labor (n = 427), induction via the same type of method where transference was suspected (n = 158), and uncomplicated spontaneous labor (n=183), the results with induced labor were better than those with spontaneous labor. In addition for the fact that the course of labor could be preplanned and the period of labor shortened intrauterine and partal complications occurred less frequently with programmed labor than with spontaneous labor. Placental complications and the tendency toward postpartum atony must be discussed. Minor complications decreased as the weight, length and gestation period of the newborn increased. Individual palpation until the physiological maturity for birth is reached would, therefore, seem to be required. Observe the conditions and increase antepartal controls. Only by setting the exact time for labor with modern methods of supervision is it theoretically possible to eliminate the danger of active management. The organizational problem involved with a general programming of labor poses the major problem at present.

Cesarean Section↗
PubMed1977

[Treatment of delayed labour with prostaglandin E2 (author's transl)].

26 patients suffering from delayed labour at term were treated with Prostaglandine E2 (PGE2). The compound was administered i.v. in a dosage of 0,5-1,0 microgram/min. Delivery was completed in 20 patients approximately 5 hours after starting the PGE2-infusion. In 6 patients delivery had to be performed by caesarean section, 4 times because of maternal and 2 times of fetal indications. In none of the cases uterine hypertension was recorded. The rate of side effects was negligible.

Adult↗
PubMed1976

Rat gastric mucosal oxygen tension, ulcer index, plasma gastrin and glucagon following restraint stress. Influence of vagotomy, splanchnicotomy and exogenous secretin.

Restraint stress ulcers in rats were developed and procedures evaluated designed at preservation of intact gastric microcirculation (pO2). Neither prior truncal vagotomy, splanchnicotomy nor combined dissection of abdominal autonomic nerves were effective in preventing the stress mediated fall of mucosal pO2 and the rise in plasma glucagon. The ulcer index remained elevated and gastrin essentially was unchanged. Prophylactic injection of increasing doses (1, 2, 4, 8, 16 U/kg secretin maintained microcirculation at pO2-levels subnormal for unstressed animals (Vmax 15.53 mm Hg; Km. 0.99 U/kg), but simultaneously brought about a continuous rise in serum gastrin. Up to 8 U/kg plasma glucagon was higher than in saline control groups reaching a peak value with 2 U/kg when ucler index showed its nadir. Secretin therapy (4, 8 U/kg) markedly improves both mucosal pO2 and ulcer index. It is suggested that breakdown of gastric microcirculation may not be solely responsible for stress ulcer development.

Animals↗