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Biomedical subjects

H Stobbe

Publications and source records attributed to H Stobbe.

At least 19 recordsLinked to original sources
PubMed1985

[Cytogenetic findings in acute myelogenous leukemias (FAB M 1 to M 6)].

The results published in the period from 1973 to 1983 entitled "Cytogenetic findings in acute myeloic leukemias" (M 1 to M 6 of FAB classification) were compiled. In 50-60 per cent of those patients affected with acute myeloic leukemia a deviating karyotype could be detected. With a markedly higher frequency chromosomes 8 and 21 will take part in aberrations, with translocations (8; 21) having the main share with about 30-40 per cent. More than half the male bearers of translocation exhibits a loss of the Y-chromosome, a third of female patients a loss of the X-chromosome. Trisomy 8 and 9 as well as monosomy 7 appear in about 20 per cent. These aberrations can also be found in all other leukemic and preleukemic processes. Patients with karyotypic abnormalities in all their cells will have the slightest average survival time and the worst appeal to therapy. The sole appearance of monosomy 7 or Ph1-chromosome respectively seems to be an unfavourable sign from a prognostic point of view. Children with acute myeloic leukemia will possess an aberrant karyotype more frequently than adults, but they have a longer average life, boys are more frequently affected by this. Acute promyelocytic leukemia can be characterized cytogenetically in 94 per cent of the cases by translocation (15; 17). However, distinct geographical differences can be observed here, the causes of which have not been elucidated. About 40 per cent of the patients with acute myelo-monocytic leukemia developed aberrations. Further investigations will have to show whether the chromosome 11 really took part in it somewhat more frequently than merely at random. Chromosome anomalies have not a visible influence on the course of the disease. In 30-40 per cent of patients with a rarely occurring acute monocytic leukemia, an abnormal karyotype could be found. There was an incidence of 47 per cent for a specific translocation (9; 11) or a similar variant respectively. Erythroleukemia is characterized by a high instability of chromosomes and karyotypical variability, particularly in erythrocyte precursors and by an average survival time of one months. Megakaryoblastic and eosinophilic leukemia are very rare kinds of acute leukemias. The small number of publications allows no general statement to be made concerning karyotypical changes.

Adolescent↗
PubMed1985

[Cytogenetic findings in chronic myelogenous leukemia].

Cytogenetic findings in chronic myeloic leukemia are represented in a survey. More than 90 per cent of CML are characterized by Ph1 chromosomes, with more than 90 per cent of the cases being involved in a translocation (9; 22). Further, non-incidental aberrations are +Ph1, isochromosome (17q) and +8 which particularly develop at the acute stage. Isochromosome 17q is assumed to be a marker for a straightly impending development of a blast crisis. Ph1-negative CML is connected with a comparatively bad prognosis for the patient. Partial trisomy 9q+ is indicated here as a marker chromosome. For the patient concerned congenital chromosome defects, such as the Down-syndrome, represent a higher risk of being affected with leukemia.

Adolescent↗
PubMed1979

[Simple diagnosis of diabetic microangiopathy by means of the tourniquet test].

The pathological results of the tourniquet test after Rumpel-Leede by the establishment of a decreased capillary resistance refers to the presence of a microangiopathy in diabetics and by its rapid and simple performance is suitable for the preliminary diagnostics, in order to judge the conditions of microcirculation. The longer the diabetes exists the oftener a pathological result is found in the tourniquet test. The form of therapy as parameter for the severity of the disease shows a direct relation to the accumulation of pathological findings of capillary resistance. In diabetic hypertensive patients regularly a pathologically decreased capillary resistance is to be found.

Adolescent↗
PubMed1979

[Determination of capillary lesions during diagnosis by means of the tourniquet test of microangiopathies in diabetes mellitus].

Decreased capillary resistance is documented by a pathologic tourniquet test (Rumpel-Leede), which demonstrates the existance of microangiopathy in diabetics. Thanks to its simple and rapid execution the tourniquet test is suitable for early diagnostic assessment of the situation in the microcirculation. The longer the patients have had diabetes, the more frequently is the tourniquet test pathological. There is also a direct correlation between the type of therapy (as an index of the severity of the disease) and the accumulation of pathologic results in measurement of capillary resistance. In diabetics with hypertension, capillary resistance is always decreased to a pathologic degree.

Capillary Resistance↗
PubMed1979

[Granulocytes in the oral cavity (author's transl)].

The counting of the granulocytes in the oral cavity ("salivary corpuscles", orogranulocytes") gives an indication to the efficiency of the granulocytopoiesis, because there exist some analogies to the emigration of granulocytes into the tissue. Two different counting methods of the orogranulocytes, their normal values (which are in correlation to the number of teeth), the influence of local factors (like inflammations in the oral cavity), the values of orogranulocytes in myeloproliferative disorders and in agranulocytosis and granulocytopenia respectively are demonstrated. Furthermore the contributions deal with the values of the orogranulocytes during the therapy with glucocorticoids. The methods described are also suitable for the estimation of the efficiency of granulozyte transfusions.

Adolescent↗
PubMed1979

[Diagnosis of malignant lymphomas].

In the diagnostics of the malignant lymphomas is to be differed between the proper diagnosing, i. e. the morphological confirmation of the disease and the enlarged diagnostics which, after ascertainment of the histologicopathological findings and prior to the beginning of a therapy is necessary for the statement of the size of the spreading of the disease (classification of stages) as well as for the inclusion in group A or B and for the registration of the most different signs of activity. Swellings of the lumph nodes in adults should be clarified morphologically after three weeks, since only on this way an early diagnostics is guaranteed. In an unclear fever an abdominal lymphogranulomatosis is to be excluded. The explorative laparotomy and splenectomy is - if possible - to be performed before the beginning of a treatment. When pronounced signs of activity are present, however, a cytostatic treatment should precede this operation in order to decrease the risik of the operation. The classification in stages with exclusively clinical examination methods at present comprises a vast number, which in all stages must always be performed as an interdisciplinary task in a haematologico-oncological centre under control of an internist. The classification after Kiel of the non-Hodgkin-lymphomas does not only demand the knowledge of the nomenclature, but also the evaluation by the internist in order to perform the optimum therapy in these patients.

Humans↗
PubMed1978

[Methods and techniques of sampling and performing of cytologic lymph node smears (author's transl)].

Within the diagnostics of lymphoma the indication for cytodiagnosis and the coice of gaining material and its preparation (punction and exstirpation of lymph nodes with making smears in a squeezing manner to effect simulated tissue pattern) are the basis of an appropriate and effective work of the cytologist. The good diagnostic efficiency of the cytodiagnosis of lymph nodes is in no proportion to the totally insufficient application of those methods by physicians of various medical disciplines in the hospitals and outpatient departments. The lack of an adequate teaching of students and postgraduates is a main reason for the described situation. In order that each physician may have the possibility to apply the cytodiagnosis of lymph nodes within his diagnostic programms, some special references are given for the gaining and preparation of lymph node material.

Cytodiagnosis↗
PubMed1978

[Non-secreting plasmacytomas].

In non-secernent plasmocytomas there are no characteristic changes of serum protein. Diagnostic difficulties may be overcome by cytomorphological examinations, immunofluorescence and electron microscopy. By referring to 4 own observations the value of the electron microscopic characteristics of plasma cells is demonstrated. Subtile investigations in protein diagnostics are required for avoiding incomplete monoclonal immunoglobulins which may greatly enter the kidneys to be overlooked. Generally the prognosis of non-secernent plasmocytomas is not worse than that of other forms.

Aged↗
PubMed1977

[Bone-marrow insufficiency].

In a survey the definition of the notions insufficiency of the bone marrow, panmyelopathy, panmyelophthisis and aplastic anaemia, the subdivision into congenital and acquired forms as well as to the clinical course, the epidemiologic situation as well as the distribution according to age and sex are described. More in detail the author enters the etiological factors, in which cases the etiological classification of the individual case may be connected with considerable difficulties. Exogenic noxae are subdivided into factors dependent on dose and independent on dose as pathogenetic principles. In this connection professional noxious substances as well as unwished side-effects of medicaments are discussed more in detail. Despite all variety the possibilities of therapy are limited.

Adolescent↗
PubMed1977

[Standard methods in a hematologic laboratory--a prerequisite for an optimal diagnosis].

State of scientific knowledge and economic prerequisites determined the selection of the optimum methods for the necessary parameters in standardizing haematologic methods. Concerning the methods of counting, measuring and staining in the haematologic laboratory, we have to do above all with so-called conventional methods with an expenditure of work considerable in most cases. In the single steps necessary for obtaining a laboratory result the physician in a clinic or outpatient department essentially participates particularly in such cases when EDTA venous blood is applied. It is especially referred to the advantage of EDTA venous blood for taking blood samples for haematologic parameters compared with the taking of capillary blood which has a high rate of error. Apart from the common efforts of physicians in clinics or out-patient departments and laboratory physicians to obtain reliable results of the findings, the use of an improved technique (particle counters, dilutor, automatic picture analysis among others) as well as further proceedings of standardization (dye for panoptic staining and others) will achieve this aim.

Blood Cell Count↗
PubMed1977

[The number and kind of leukocytes in the saliva (salivary corpuscles) in healthy subjects and in patients].

In the form of a survey a report is given on the concept of the saliva corpuscle, its origin, composition, different degree of damage, its number and function. The quantitative behaviour enables a statement to be made about the actual unspecific cellular defence in parodontopathy (increased number of saliva corpuscles) and in various blood diseases (decreased number of saliva corpuscles. This has a particular diagnostic value.

Adolescent↗