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Biomedical subjects

H Stoll

Publications and source records attributed to H Stoll.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Pelvimetry using magnetic resonance tomography].

20 woman were examined before and after partum by means of conventional and magnetic resonance pelvimetry. Besides the usual data regarding the morphology and diameters of the pelvis, MRI gives information on the soft tissues of the birth canal without the added risk of irradiation to the mother and foetus. As shown by studies done in the USA it is also possible to determine foetal maturity by MRI; this will be done in the future.

Female↗
PubMed1985

An inquiry into the epidemiology of melanoma.

The authors conducted a study of 404 melanoma patients and 521 control patients of both sexes at Roswell Park Memorial Institute. As have previous investigators, they found that higher risk attaches to upper socioeconomic status, as measured by occupation and education, lightness of complexion and hair, and amount of blue in the admixture of eye color. The authors also found a higher risk among individuals who reacted to sun exposure by burning, blistering, or freckling rather than by tanning. A particular concern was to measure risk associated with exposure to the sun. As have two other investigators, they found that risk decreased with increasing exposure, suggesting either that individuals continually exposed to the sun have less risk because of tanning, or that susceptibles purposely avoid sun exposure, or both. The fact that melanoma occurs with greater frequency on sites exposed to the sun suggests that sun exposure plays a part. These studies showed a dose-response increase in risk (odds ratios of up to 4 for males and over 6 for females) with increases in number of traits possessed, such as light complexion, and burning or freckling in response to sun exposure. This is consistent with the authors' earlier finding of a strong familial aggregation of melanoma.

Adult↗
PubMed1981

A genetic analysis of melanoma--polygenic inheritance as a threshold trait.

A total of 214 melanoma patients and 193 age- and sex-matched controls, interviewed at the Roswell Park Memorial Institute during the years 1974--1978, provided information regarding 1134 and 1043 New York State first order relatives (parents, offspring and siblings). The vital information provided was checked against the records of the New York State Tumor Registry to find cases of melanoma among relatives. Five cases of melanoma were found among the 1027 New York State relatives of melanoma index cases alive during the period 1949--1978, inclusive. No cases of melanoma were found among New York State relatives of controls. The expected number of melanomas among a cohort of relatives of identical sex and age composition for the interval was 0.625 cases, giving a ratio of observed to expected of 8.0. A similar analysis, restricted to parent-offspring pairs, yielded a ratio of observed to expected of 12.7. A search for additional melanoma cases among second degree relatives of familial index cases yielded no further affected relatives. The incidence of melanoma among relatives of melanoma cases and in a comparable general population were used to estimate the heritability of liability to melanoma as a polygenic trait. A heritability estimate of 0.49 was obtained, using parent-offspring data, indicating that nearly half of the variability in liability to melanoma in this population may be attributed to the additive action of many genes, each with small effect. Pending the replication of these findings, the 12-fold increase in incidence of melanoma among parents and offspring of melanoma cases suggests the importance of counseling and surveillance of relatives of affected individuals by the clinician.

Adult↗
PubMed1980

Melanomas of the palm, sole, and nailbed: a clinicopathologic study.

Acral lentiginous melanoma is a newly recognized subtype of malignant melanoma that occurs on volar and subungual skin. Histologic examination of 69 primary volar and subungual melanomas revealed 31 (45%) acral lentiginous, 18 (26%) superficial spreading, and two (3%) nodular melanomas. Eighteen biopsies were inadequate for subclassification. Seventy-one percent (49/69) occurred on plantar skin, 10% (7/69) on the palm, and 19% (13/69) on nailbeds. Plantar melanomas occurred most frequently on weight-bearing areas, particularly the heel (45%). Most were level 4 or 5 at the time of diagnosis. The overall five-year survival of patients with plantar melanomas was 43%. The mitotic rate showed an inverse relationship with survival. The ratio of volar skin melanomas to subungual melanomas was 4:1. Ninety-two percent of subungual melanoma occurred on the thumb or great toe. The five-year survival for palmar and subungual melanomas was 19%. Our data confirm that acral lentiginous melanoma is a distinct subtype of melanoma with a unique histologic appearance and behavior, but not all volar and subungual melanomas are the acral lentiginous type.

Adult↗