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H Stolze

Publications and source records attributed to H Stolze.

At least 37 records · Page 2Linked to original sources
PubMed1997

Gait quantitation in Parkinson's disease--locomotor disability and correlation to clinical rating scales.

Stride parameters were established in 17 patients with idiopathic Parkinson's disease (PD; mean age 68.8 yrs.; Hoehn-Yahr stages 2 and 3) and in 33 healthy age-matched controls. Free-walking speed was lower in PD as were stride length and cadence. Impaired locomotor synergies in PD were reflected by a higher coefficient of variation of stride length; step width and its coefficient of variation (the latter related to postural imbalance in locomotion) were not changed. No stride parameter correlated with any total score of either the Hoehn-Yahr Scale, the Unified Parkinson's Disease Rating Scale Motor Examination ("UPDRS-III"), the Columbia Rating Scale (CURS) or the Webster Rating Scale. Stride length correlated with a CURS-Bradykinesia-Score, whereas gait velocity correlated with UPDRS-III-Axial-Motor-Score and with the CURS-Bradykinesia-Score. Hypokinesia of gait in moderately disabled PD patients is best assessed by combined analysis of stride parameters and locomotion-related subscores from conventional rating scales.

Aged↗
PubMed1997

Gait analysis during treadmill and overground locomotion in children and adults.

Gait analysis on the treadmill and in the overground condition is used both in scientific approaches for investigating the neuronal organisation and ontogenetic development of locomotion and in a variety of clinical applications. We investigated the differences between overground and treadmill locomotion (at identical gait velocity) in 12 adults and 14 children (6-7 years old). During treadmill locomotion the step frequency increased by 7% in adults and 10% in children compared to overground walking, whereas the stride length and the stance phase of the walking cycle decreased. The swing phase, however, increased significantly by 5% in adults and remained unchanged in children. Balance-related gait parameters such as the step width and foot rotation angles increased during treadmill locomotion. The reduction of the step length was found to be stable after 10 min of treadmill walking in most subjects. With regard to the shifted phases of the walking cycle and the changed balance related gait parameters in the treadmill condition, we assume a different modulation of the central pattern generator in treadmill walking, due to a changed afferent input. Regarding the pronounced differences between overground and treadmill walking in children, it is discussed whether the systems generating and integrating different modulations of locomotion into a stable movement pattern have reached full capacity in 6-7 year old children.

Adult↗
PubMed1996

[18 months long-term analysis of effectiveness, safety and tolerance of sumatriptan s.c. in acute therapy of migraine attacks].

The aim of the open prospective study was to investigate the efficacy, safety and tolerability of subcutaneous sumatriptan in acute migraine treatment. Patient self-treatment was monitored over a time period of 6-18 months with 6 mg of sumatriptan administered subcutaneously by an autoinjector. In total, 2,263 patients participated in the study. Headache intensity was documented by the patient in a headache diary before and 1 and 2 h after application. During the study period from October 1991 to June 1993, 43,691 migraine attacks were investigated. Treatment with sumatriptan was efficient in 89.5% of the attacks. Headache relief was achieved in 71%. Headache reoccurred in 22.7% of the attacks, and therefore a second injection was administered. An intraindividual treatment efficacy of 80-100% was achieved in 82.9% of the patients. During long-term treatment the ratio of effective treatment and headache frequency was constant; 4.9% of the patients withdrew from the study because of adverse events and because they felt the treatment was not effective. A total of 44.5% of the patients reported adverse events that were serious in 1.7%. Subcutaneous self-treatment with sumatriptan in the acute treatment of migraine is effective and well tolerated by the patients.

Adult↗
PubMed1995

Defective production of interleukin-2 in patients with idiopathic Parkinson's disease.

The pathogenesis of Parkinson's disease (PD) is largely unknown. Recently, several studies have presented evidence of an immunological dysfunction in patients suffering from PD. We studied the immune responsiveness of patients with idiopathic PD (n = 20) by investigation of the ability of peripheral blood mononuclear cells to produce cytokines after mitogenic stimulation in a whole blood assay. A group of age-related healthy blood donors served as control (n = 19). Additionally, white blood count, leukocyte differentiation and lymphocyte subtyping were performed. PD patients had a significantly higher neutrophil count, but analysis of T-cell subsets showed no difference between the two groups. In peripheral blood, secretion of interleukin-2 (IL-2) after mitogenic stimulation was significantly diminished in the patients' group (p < 0.01), whereas values of IFN-alpha 2, IL-6, IFN-gamma and sIL-2R were comparable in both groups. IL-2 production correlated negatively with the mean annual dose of levodopa treatment and correlated significantly (p < 0.002) with amantadine uptake. Analysis of sex, age, duration of illness and other drug intake revealed no correlation with cytokine release. Our findings support the view that there is a selective abnormality in the immune repertoire of peripheral blood lymphocytes in patients suffering from PD, the reasons for which need to be explored.

Aged↗
PubMed1981

Effect of La3+ on secretagogue-induced Ca2+ fluxes in rat isolated pancreatic acinar cells.

Addition of 0.1 mmol/l of La3+ to pancreatic acinar cells increased both the rate and extent of 45Ca+ uptake. Addition of 0.3 mmol/l La3+ did not change cellular 45Ca2+, whereas 1, 2, and 5 mmol/l gradually decreased it. If carbamylcholine (CCh) or the octapeptide of cholecystokinin-pancreozymin (CCK-OP) was added in the presence of low La3+ concentrations (0.1 and 0.3 mmol/l) to 45Ca2+-equilibrated cells, secretagogue-induced 45Ca2+ release-reuptake was not inhibited. At 1 and 2 mol/l of La3+, however, secretagogue-induced 45Ca2+ release was abolished, whereas uptake of 45Ca2+ was still increased by CCK-OP and CCh. At 5 mmol/l La3+, the effects of secretagogues were completely abolished. In the presence of 2 mmol/l La3+, the atropine-induced 45Ca2+ uptake in CCh-pretreated cells and the dibutyryl guanosine 3',5'-cyclic monophosphate-induced 45Ca2+ uptake in CCK-OP-pretreated cells were highly reduced. The data are interpreted to support our assumption that CCK-OP and CCh increase the plasma membrane permeability to Ca2+ in pancreatic acinar cells in addition to their action to initiate release of CA2+ from an intracellular Ca2+ trigger pool.

Animals↗
PubMed1980

Effect of atropine, ouabain, antimycin A, and A23187 on "trigger Ca2+ pool" in exocrine pancreas.

45Ca2+ fluxes have been analyzed in dispersed acinar cells prepared from rat pancreas. Sudden addition of carbamylcholine (CCh) to 45Ca2+-preloaded acinar cells at quasi-steady state for 45Ca2+ resulted in a quick 45Ca2+ release followed by a slower 45Ca2+ reuptake with net accumulation of 45Ca2+. Subsequent sudden addition of atropine caused a further transient increase in cellular 45Ca2+ followed by a slow decrease to a steady-state value. 45Ca2+ release could not be evoked a second time by pancreozymin when prestimulated with CCh. However, if CCh stimulation was abolished by an interposed step of atropine, restimulation by cholecystokinin-pancreozymin was possible. Addition of A23187 or antimycin A to cells induced a fast decrease in cellular 45Ca2+. This effect was not additive to the CCh effect. In ouabain-pretreated cells, the CCh-induced sudden loss of cellular 45Ca2+ was blocked by 60%. The following slow reuptake of 45Ca2+ was blocked completely. Subsequent addition of atropine caused a fast uptake of cellular 45Ca2+ with no secondary decline. The data are consistent with the following model: acetylcholine releases Ca2+ from a cellular "trigger pool" into the cytosol located in or near the cell membrane. Then Ca2+ is extruded from the cell via Ca2+ pumps partly by a Na+-dependent Ca2+ transport system (quick phase of 45Ca2+ release). Subsequently, due to increased Ca2+ permeability of the plasma membrane as induced by acetylcholine, Ca2+ influx occurs and Ca2+ is taken up from the cytosol into intracellular Ca2+ pools (slow 45Ca2+ reuptake phase). Atropine causes refilling of the trigger Ca2+ pool and return of the increased Ca2+ permeability of the plasma membrane back to the unstimulated state.

Amylases↗
PubMed1975

[Confidence and fear of the doctor when meeting the suicidal patient (author's transl)].

In the encounter with the suicidal patient, the doctor enters a field of emotional high tension. He seeks to protect himself against the fear which agressive and destructive tendencies arouse in him by measures which are, in many respects, questionable. The doctor can only find real confidence when faced with a suicidal patient if he perceives his own insecurity and fears. Consequently the treatment of the suicidal patient becomes a permanent balancing act. In describing here three important polarities an attempt is made to make this risk of the attitude of suspense and the therapeutic possibilities arising from it intelligible.

Adult↗
PubMed1975

Nuclear deoxyribonucleic acid content in congenital cardiac malformations.

Cytophotometric measurements of the DNA content of human heart muscle nuclei were performed on normal and congenitally malformed hearts of children. Congenital malformations of the heart lead to an early increase of the ploidy pattern as a sign of myocardial overload. This increase is significant. It starts, at the earliest, after the 3rd week of life. The degree of polyploidization of the muscle nuclei in malformed hearts is dependent on the type of overload. Pressure load produces a stronger shift to higher ploidy values than does volume load. The polyploidization is not dependent on either the heart weight at autopsy or the age of the child. It may be concluded that increasing functional requirement is the main cause of physiological and pathological polyploidization in hearts of children.

Age Factors↗
PubMedDate not supplied

Stride parameters in healthy young and old women--measurement variability on a simple walkway.

Gait analysis in disabled and old probands may be considerably altered by applied devices and the artificial surrounding of a gait laboratory. To circumvent distractions from such factors, we evaluated the gait pattern of healthy women on a simple walkway and supplemented the analysis by reliability measurements. In order to consider age-related changes of gait parameters in health, healthy young (YHW) and old women (OHW) were investigated. Five gait parameters were assessed during 10 independent runs of each individual on the walkway. Multiple-regression analysis revealed a significant relationship between age and gait velocity, stride length, and the coefficient of variation (CV) of step width. Standard errors of mean were uniformly low across all parameters and groups, except for some increase in step width (OHW) and cadence (YHW). Across groups, CV was small for stride length, larger for foot angle, and largest for step width. An acceptably low within-session variability of the stride parameters was found.

Adult↗