Biomedical subjects

H Stutte

Publications and source records attributed to H Stutte.

At least 19 recordsLinked to original sources

PubMed1999

[Soft-tissue sonography in the follow-up care of breast cancer: indications of liver metastases caused by lymphatic spread].

AIM: During follow-up care of breast cancer patients a prospective study was carried out to answer two questions: 1. Can soft-tissue sonography improve early detection of locoregional metastases? 2. Can a combination of soft-tissue sonography and ultrasound liver examination provide information about the lymphogenous spread of metastases? METHOD: 312 unselected breast cancer patients were examined sonographically. The examinations included 9 lymph node regions of the efferent lymphatic ducts, along with the chest wall and the liver. Further examinations of the soft-tissue metastases were carried out with a different imaging technique or histologically, or with a combined sonographic and clinical follow-up, as a control. RESULTS: Sonography revealed 112 locoregional metastases in 49 patients (15.7%); 62 of these metastases (55%) were non-palpable. Especially metastases in the axillary level II and III areas, interpectoral and intramuscular recurrences and internal mammary lymph node metastases were found to be non-palpable, except in a very advanced stage. Liver metastases often occurred in conjunction with internal mammary lymph node metastases. Liver metastases were the only manifestation of distant metastasis in three patients with internal mammary lymph node metastases, all of whom were in the fifth year after mastectomy. CONCLUSION: Soft-tissue sonography greatly improves early detection of locoregional metastases of breast cancer. There seems to be the possibility that liver metastases of breast cancer can develop lymphogenously via internal mammary lymph node metastases.

Adult↗

PubMed1992

[Intralesional therapy of melanoma metastases with recombinant interferon-beta].

In ten patients with metastasizing melanomas, discontinuous intratumoral treatment with recombinant interferon beta (rIFN-beta) was administered into 19 cutaneous or palpable subcutaneous metastases. Among the 16 metastases treated with 5 x 10(6) IU per injection, 8 showed partial or complete remission. No recurrence was observed during the 4-9-month follow-up period. There was no regression in 3 metastases treated with 3 x 10(6) IU rINF-beta per injection. No systemic antineoplastic effects were observed in any of the cases. The IFN-beta serum levels were measurably increased following intratumoral application. Local treatment led to a significant increase in (2'-5')oligoadenylate synthetase in the mononuclear blood cells and in the serum. Side-effects of the treatment were moderate; there was a temporary increase in transaminases, a decrease in thrombocytes and influenza-like symptoms. The results show that IFN-beta has a dose-dependent antitumour effect on malignant melanomas.

Adult↗

PubMed1989

Ultrasonographic diagnosis of melanoma metastases in liver, gallbladder, and spleen.

Ultrasonographic findings in the liver, gallbladder, and spleen of 42 patients with metastatic melanoma of the skin are described in a retrospective study stressing sonomorphologic results. Liver metastases were detected in 27 (64%) of the patients. Clinically asymptomatic melanoma metastases were found in the gallbladder of three patients and in the spleen of three others. The liver metastases were still in the initial stages in 10 patients, whose survival times averaged 8.4 months. The significance of upper abdominal ultrasonography in assessing the spread of metastasizing malignant melanoma during follow-up is emphasized.

Female↗

PubMed1989

[Lymph node sonography in the after care of malignant melanoma].

Sonographic and palpatory lymph node findings were compared with the results of surgery or regular examination in a retrospective study of 167 melanoma patients. Sonography proved highly advantageous for diagnosis: whereas palpation indicated tumors at 83 of 277 lymph node locations, sonography showed 36 of the 83 to be false-positive. Moreover, sonography allowed the correct diagnosis of 6 non-palpable lymph node metastases. Sonographic diagnosis was initially uncertain in only 15 cases. Differential diagnoses and the limitations of lymph node sonography are described, and suggestions made for the application of this method in the postoperative care of melanoma patients.

Humans↗

PubMed1987

[Early sonographic recognition of renal cell carcinoma].

Of 19 patients with renal cell carcinoma diagnosed by ultrasound, nine already had symptoms of the tumor at the time; in the other ten it was discovered by chance during an upper-abdominal ultrasound screening. The latter group differed from the former by a lower average age (52.7 compared with 63.1 years), lower mean tumor size (4.5 and 7.0 cm, respectively), less advanced tumor stage, further course with fewer complications, and higher survival rate. The findings underline the great importance of routine abdominal ultrasound screening in the early diagnosis of tumors.

Carcinoma, Renal Cell↗

PubMed1981