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H T Co

Publications and source records attributed to H T Co.

2 recordsLinked to original sources

Scleroderma lung: pathogenesis, evaluation, and current therapy.

Interstitial lung disease (ILD) is now the most common cause of mortality in scleroderma, although its pathogenesis remains poorly understood. Management requires early detection and treatment before the onset of lung fibrosis. In a number of uncontrolled studies, the combination of daily oral cyclophosphamide and low-dose prednisone appears to be effective, although these conclusions have yet to be confirmed.

Adrenal Cortex Hormones↗

Effect of 2-alkanols on the separation of geometric isomers of retinol in non-aqueous high-performance liquid chromatography.

The effects of 2-alkanols as mobile phase modifiers on the resolution of 11-cis-, 13-cis-, 9-cis- and all-trans-retinol in high-performance liquid chromatography were studied. Partisil-10-ODS and Zorbax CN columns were used in series. The retentions of 9-cis-and all-trans-retinol were significantly influenced by the presence of long-chain 2-alkanols in the mobile phase. Baseline separation of 9-cis-and all-trans-retinol was achieved when 1% 2-heptanol in hexane was used as the eluent. On the other hand, the separation of 11-cis-from 13-cis-retinol required 5% dioxane in hexane. The method is applicable to the separation of retinol isomers present in biological samples. Analysis of normal rat liver lipids showed the presence of a small amount of 13-cis-retinol in addition to all-trans-retinol.

Animals↗