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H T Zhu

Publications and source records attributed to H T Zhu.

5 recordsLinked to original sources
PubMed2001

[Nasal/nasopharyngeal T/NK-cell lymphomas with evident angiogenic activity].

OBJECTIVE: To search the difference of the angiogenic activity between T/NK-cell lymphomas and B-cell lymphomas. METHODS: The T/NK-cell was stained immunohistochemically by CD56 and CD45 RO, the B-cell was by CD20, the microvessel endothelium was by CD34. Sixty-one cases were studied to examine the immunophenotype and to estimate the intratumoral microvessel density (iMVD). RESULTS: Forty in 61 cases (65.6%) expressed the immunophenotype of both T-cell and Natural Killer cell, were diagnosed T/NK-cell lymphomas. Fifteen in 61 cases (24.6%) expressed the immunophenotype of B-cell. There was a significant difference in incidence between the two types of lymphomas (chi 2 = 22.4, P < 0.01). The mean of iMVD/HPF was 24.1 +/- 8.7 in 40 cases of T/NK-cell lymphomas, while the mean of iMVD/HPF was 14.9 +/- 3.8 in 15 cases of B-cell lymphomas. The difference (t = 3.7, P < 0.05) was significant. CONCLUSION: The angiogenic activity of T/NK-cell lymphomas is much more than that of B-cell lymphomas. This study shows nasal/nasopharyngeal T/NK-cell lymphomas are with evident angiogenic activity.

Adult↗
PubMed2000

Statistical analysis of nonlinear structural equation models with continuous and polytomous data.

A general nonlinear structural equation model with mixed continuous and polytomous variables is analysed. A Bayesian approach is proposed to estimate simultaneously the thresholds, the structural parameters and the latent variables. To solve the computational difficulties involved in the posterior analysis, a hybrid Markov chain Monte Carlo method that combines the Gibbs sampler and the Metropolis-Hasting algorithm is implemented to produce the Bayesian solution. Statistical inferences, which involve estimation of parameters and their standard errors, residuals and outliers analyses, and goodness-of-fit statistics for testing the posited model, are discussed. The proposed procedure is illustrated by a simulation study and a real example.

Humans↗
PubMed1994

Structure of the nucleocapsid protein gene of rice yellow stunt rhabdovirus.

The complete nucleotide sequence of the N protein gene of rice yellow stunt rhabdovirus (RYSV) was determined by sequencing of cDNA clones derived from the viral genomic RNA. The 3' end of the N gene (messenger sense) was defined by sequence analysis of cDNA clones generated from the N protein mRNA by 3'RACE. The 5' end sequence of the gene was putatively assigned as 5'-AACAC-3'; this sequence is found in the presumed 3' leader/N gene junction region. The mRNA encoding the RYSV N protein is 1714 nt comprising a 15-nt untranslated 5' leader sequence followed by an open reading frame (ORF) of 1563 nt and a 136-nt untranslated 3' region. The calculated molecular mass of the N protein encoded by the ORF is 58,400 Da, which is larger in size than N proteins of other rhabdoviruses. Amino acid composition analysis shows that the RYSV N protein is rather basic with a predicted isoelectric point of 10.04; indeed, a large highly basic region could be found at the carboxy terminal portion of the protein. Amino acid sequence comparison between N proteins of RYSV and sonchus yellow net virus, both of which belong to the same genus Nucleorhabdovirus, revealed an overall 30% identity, with three relatively conserved blocks of 14-20 amino acid residues. Moreover, the hydropathy profiles of the two proteins are generally similar. The structural similarities between the N protein of RYSV and that of lettuce necrotic yellows virus, the type member of the genus Cytorhabdovirus, and those of animal rhabdoviruses, are less significant. Nucleotide sequence determination of 5' and 3' regions flanking the RYSV N gene identified a 14-nt common sequence that is very similar to the consensus gene junction sequences of other plant and animal rhabdoviruses.

Amino Acid Sequence↗