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Biomedical subjects

H Tacier-Eugster

Publications and source records attributed to H Tacier-Eugster.

4 recordsLinked to original sources
PubMed1980

Atopic allergy, serum IgE and RAST specific IgE antibodies in patients with cystic fibrosis.

The occurrence of allergic diseases is studied in a group of 56 Swiss children suffering from cystic fibrosis (CF). 27% of CF children showed allergic manifestations, and 61% of CF children had positive family history for atopic diseases. The occurrence of allergies is increased in homozygotes as well as in heterozygotes for CF. Total serum IgE values are clearly increased in atopic CF children, but also slightly elevated in CF patients without allergic manifestations. Occurrence of specific IgE (RAST) for the house dust-mite Dermatophagoides pteronyssinus, timothy grass pollen. Aspergillus fumigatus and Penicillium is summarized.

Adolescent↗
PubMed1976

Studies on the immune status of children with acute lymphocytic leukaemia. I. Early phase before and after first remission.

Seventeen children of 2-15 years of age with newly diagnosed untreated acute lymphatic leukaemia (ALL) were evaluated with a number of immunological tests: for humoral immunity serum immunoglobulins and reactive antibody formation against three antigens (diphtheria, tetanus, KLH); for cell-mediated immunity in vitro response of blood lymphocytes against PHA; membrane characteristics of blood lymphocytes and lymphoid blasts for both B and T cells. The tests were repeated in thirteen patients who attained full remission. In the majority (twelve cases) no surface markers were detected (null-cell leukaemia), one patient fulfilled the criteria for a T-cell leukaemia with thymoma. Four patients had rather high absolute B-cell counts, but did not fulfill all the criteria for B-cell leukaemia; three of them died before remission. Immune globulin concentrations were only slightly changed, antibody formation, both primary and anamnestic, was possible. PHA response was extremely low in the initial phase, but normal immediately after remission. During remission all patients were markedly depleted in both their B- and T-cell compartment.

Adolescent↗
PubMed1976

Studies on the immune status of children with acute lymphocytic leukaemia. II. In remission with and without cytostatic treatment.

In eleven children with acute lymphocytic leukaemia (ALL), cytostatic treatment was stopped after sustained remission lasting for 9 months--6 1/2 years. Their immunological status was monitored every 6--12 weeks during the first year after cessation of therapy. Rebound of depressed parameters was observed for absolute lymphocyte, B-cell and T-cell counts and for immunoglobulins. A simple follow-up scheme for such patients is proposed.

Antibody Formation↗