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Biomedical subjects

H Takeuchi

Publications and source records attributed to H Takeuchi.

At least 883 records · Page 49Linked to original sources
PubMed1983

Serum mitochondrial aspartate aminotransferase in patients with polymyositis.

The clinical significance of serum aspartate aminotransferase (GOT) isozymes was studied in 18 patients with polymyositis. Abnormally high levels of mitochondrial GOT (mGOT) (6.2 +/- 1.2 IU/L, mean +/- SEM; normal, less than 2.0 IU/L) and cytosol GOT (sGOT) (95 +/- 21.6 IU/L; normal, less than 25 IU/L) were observed in sera. In polymyositic muscles, the sGOT level was significantly decreased but mGOT was not. The levels of serum sGOT and mGOT and the ratio of mGOT/tGOT before corticosteroid therapy correlated well with the severity of muscle weakness. Serial determination of CPK, sGOT, and mGOT during corticosteroid therapy revealed that mGOT most rapidly returned to normal. Exercise did not increase serum mGOT in polymyositis.

Adrenal Cortex Hormones↗
PubMed1983

Torulopsis infection extensively involving urinary tract.

A case report of extensive and severe urinary tract infection caused by Torulopsis glabrata is presented. In this multiple antibiotic therapy, multiple surgical procedures, and urinary obstruction due to urolithiasis are believed to be factors predisposing to an opportunistic fungal infection.

Amphotericin B↗
PubMed1983

Constriction of fetal ductus arteriosus by non-steroidal anti-inflammatory drugs.

Transplacental effects of 24 non-steroidal anti-inflammatory drugs (NSAIDs) on the fetal ductus arteriosus were studied in full-term pregnant rats using the whole-body freezing technique. All sixteen acidic NSAIDs constricted the fetal ductus in a dose-dependent relationship, but considerable differences in the intensity of effect was noticed with the clinical dose of each drug. Six of the eight basic NSAIDs did not constrict the fetal ductus at 50 to 100 times the usual clinical dose. It is concluded that acidic NSAIDs probably should not be administered to pregnant women. However, it may be established in the future that some basic NSAIDs can be administered safely to pregnant women without hazardous effect on the fetus.

Age Factors↗
PubMed1983

Identification of three further giant neurons, r-APN, INN and FAN, in the caudal part on the dorsal surface of the suboesophageal ganglia of Achatina fulica Férussac.

In addition to the neurons of Achatina fulica Férussac examined previously, three more giant neurons, r-APN (right-anterior pallial neurons), INN (intestinal nerve neuron) and FAN (frequently autoactive neuron), were identified in the suboesophageal ganglia of the same animal. R-APN (200-250 microns in diameter), the somatic membrane of which was usually silent, was found near the exit of the right anterior pallial nerve in the right parietal ganglion. The most important feature in identifying the neuron is the one-by-one correspondence of somatic spikes to impulses in the right anterior pallial and the left anterior pallial nerves. R-APN was excited markedly by dopamine, 5-hydroxytryptamine, L-homocysteic acid, erythro-beta-hydroxy-L-glutamic acid and acetylcholine, and inhibited by GABA. INN (150-200 microns in diameter), which was also silent, was situated near the intestinal nerve in the visceral ganglion. INN somatic spikes corresponded to the impulses in the intestinal nerve. INN was excited by 5-hydroxytryptamine and histamine. Acetylcholine had biphasic effects (inhibitory followed by slight excitatory). FAN (100-150 microns in diameter), showing frequent spike discharges, about 60-120/min, was situated somewhat further from the exit of the left posterior pallial nerve in the visceral ganglion. No clear correspondence was observed between the FAN somatic spikes and impulses of any nerves. FAN was excited by 5-hydroxytryptamine, GABA and acetylcholine, and inhibited by octopamine and erythro-beta-hydroxy-L-glutamic acid.

Action Potentials↗
PubMed1983

Juvenile granulosa cell tumor associated with rapid distant metastases.

We have encountered a case of juvenile granulosa cell tumor, first described by SCULLY as a specific form of granulosa cell tumor, in a 23-year-old, nulliparous female associated with some unusual clinicopathological features. The tumor showed a diffuse or macrofollicular pattern with eosinophilic or clear, often vacuolated cytoplasm containing abundant lipid. Ultrastructures revealed features very similar to those of previously reported juvenile granulosa cell tumor. Intracytoplasmic filaments were observed, but smooth surfaced endoplasmic reticulums were not evident. The patient succumbed unexpectedly rapidly due to recurrence and distant metastasis, in spite of anti-cancer therapy. It is also interesting that surprisingly high levels of estrogens as well as testosterone in both urine and serum was recorded before surgery and after the development of recurrence.

Adult↗
PubMed1983

[A study on urinary fungal infection].

We analyzed 20 cases of urinary fungal infection experienced at our Department, during the last 2 years. Candida albicans was the most prevalent of the fungi affecting the urinary tract. Torulopsis glabrata and Candida tropicalis were also prevalent. Antibiotics, indwelling catheter and obstructive uropathy were the most prevalent predisposing factors of the fungal infection. Of 20 cases of fungal infection, 5 cases were cured only by elimination of the predisposing factors, and 15 cases were treated and resolved by administration of sodium bicarbonate, 5-fluorocytosine and or irrigation with amphotericin B. But one case of bilateral renal torulopsiosis developed into renal failure, and 4 cases died of the primary disease.

Adolescent↗
PubMed1983

Effects of synthetic ergot derivatives on the two identifiable giant neurons, sensitive to dopamine, of Achatina fulica Ferussac.

On the two dopamine (DA)-sensitive giant neurones, PON (periodically oscillating neuron, excited by DA) and TAN (tonically autoactive neuron, inhibited by DA), of an African giant snail (Achatina fulica Férussac), effects of synthetic ergot derivatives, including lisuride and pergolide, which are considered to be dopamine agonists, were examined. Of the substances examined, three of the ergot derivatives related to pergolide, D-8,9-didehydro-6-propylergoline-8-methanol (LY149174), D-6-methyl-8 beta-(2-(methylsulfinyl)ethyl)ergoline (LY116470) and D-2-chloro-6-methyl-8 beta-(2-(methylsulfinyl)ethyl)ergoline (LY127817), showed excitatory effects on PON, while pergolide (D-8 beta-( (methylthio)methyl)-6-propylergoline, LY127809) and lisuride (N-D-6-methyl-8-isoergolenyl-N',N'-diethylcarbamide) had no effect. On the other hand, only D-6-methyl-8 beta-(2-(methylsulfinyl)ethyl)ergoline (LY116470) had any excitatory effects on TAN.

Animals↗
PubMed1983

Constriction of fetal ductus arteriosus by nonsteroidal antiinflammatory drugs.

Transplacental fetal ductal constriction was studied for 24 NSAIDs in full-term pregnant rats. All 16 acidic NSAIDs constricted the fetal ductus, but considerable differences in the grade of effect were noticed with the clinical doses of each NSAID. Six of the eight basic NSAIDs did not constrict the fetal ductus. It is concluded that acidic NSAIDs should not be administered to pregnant women. However, it may be established in the future that some basic NSAIDs can be administered safely.

Animals↗
PubMed1983

[Treatment of infection stones. I. Dissolution of experimental infection stones in rats].

The in vivo solubility of struvite stones experimentally induced in rats was investigated. The struvite stones implanted into bladders of normal rats were reduced in weight; and, they were dissolved by oral administration of ammonium chloride. Cefmetazone cured pyelonephritis and dissolved the bladder stones when it was administered to rats with urinary tract infection caused by Proteus mirabilis. Normalization of urine by antibiotics and acidifying agents may dissolve struvite stones, and help treat infection stones.

Ammonium Chloride↗
PubMed1983

[Prevention of infected urinary stones by urease inhibitor. IV. Treatment of infection stones in rats by a new hydroxamic acid and cefalexin].

We investigated the combined effectiveness of a new urease inhibitor, N-( pivaroyl ) glycinohydroxamic acid, with Cefalexin in the treatment of infection stones in rats. Combination therapy with the hydroxamic acid and Cefalexin inhibited bladder stone formation, and dissolved the stone dose dependently, while separate therapy was not significantly effective against stone formation or bacterial growth. This compound may become a useful medicine for the treatment of infection stones.

Animals↗