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Biomedical subjects

H Takeuchi

Publications and source records attributed to H Takeuchi.

At least 937 records · Page 52Linked to original sources
PubMed1981

The therapeutic effect of concurrent administration of 5-fluorouracil and allylestrenol or hexestrol in small doses on prostatic carcinoma.

A trial to reduce the dosage of estrogen or to substitute it by other agents was done as a treatment of prostatic carcinoma. Either the combination of 5-FU (200 mg/day) and allylestrenol (50 mg/day), or 5-FU and hexestrol (20 mg/day) was given to 24 cases of prostatic carcinoma, 4 of whom were relapsed hormonal-resistant cases, 14 cases were controlled by large doses of estrogen and 6 were newly treated cases. No progressions were observed following 3 months of therapy. In 5 cases, progression was observed after 6 months. Deteriorated cases increased to 6 cases after 12 months. The effective rate, according to the "vital score," which is proposed as a parameter of the physical condition of patients with prostatic carcinoma, was calculated to be 100% at 3 months, 77% at 6 months, and 71% at 12 months.

Aged↗
PubMed1981

An automatic voltage adjuster for a single microelectrode recording of the membrane potential and resistance.

An automatic voltage adjuster was designed in order to apply an intracellular rectangular pulse of current and record the membrane potential simultaneously using a single intracellular microelectrode. The original voltage record consists of a rectangular signal signal (Va) due to the resistance of the microelectrode and a slowly rising signal (Vb) which is the proper value of the membrane potential shift produced by the application of the intracellular rectangular pulse of current. The instrument described in this paper samples the original signal (Va + Vb) at 0.5 approximately 1.0 ms after the application of the rectangular pulse of current, holds this voltage level (Va) and subtracts it from the original signal (Va + Vb) to obtain (Vb).

Animals↗
PubMed1981

Lateral mobility of erythrocyte membrane proteins studied by the fluorescence photobleaching recovery technique.

Erythrocyte membrane peripheral and integral proteins have been isolated and purified, and the lateral diffusion of these proteins in a well-defined phospholipid bilayer matrix (dimyristoylphosphatidylcholine) has been studied by fluorescence photobleaching recovery measurements. Our own instrument for the recovery measurements is described and some data for lipid diffusions are compared with those previously reported by other investigators. The peripheral proteins (spectrin and band 4.1) diffuse rapidly on the lipid membrane in its fluid phase. The diffusion constant of approximately 5 x 10(-8) cm2 . s-1 (30 degrees C) was only a little smaller than that for lipid diffusion. The diffusion was greatly slowed down when the host lipid matrix became solid. The integral protein band 3 also diffuses rapidly in the fluid membrane. The diffusion constant of 1.6 x 10(-8) cm2 . s-1 (30 degrees C) was smaller than those for lipids and for the peripheral proteins. The lateral motion is compatible with diffusion of a cylinder with radius 3 nm in a two dimensional matrix with an inner viscosity of 2 poises and an inner thickness of 4 nm. The band 3 lateral motion was restricted by binding of the cytoskeletal component proteins (ankyrin, spectrin, actin, and band 4.1) to the reconstituted membranes. The diffusion constant decreased to half. The results provide a basis for the elucidation of transmembrane control mechanisms in more complex cellular systems.

Anion Exchange Protein 1, Erythrocyte↗
PubMed1981

Primary cerebral malignant lymphoma with macroglobulinemia and carcinoma of the colon.

A case of primary cerebral malignant lymphoma, immunoblastic type was reported. The immunoelectrophoresis of the patient serum showed an abnormal bow of IgM lambda type. Autopsy revealed that the cerebral lymphoma showed no extracranial spread except for adenocarcinoma of the colon with hepatic metastasis. Ultrastracturally, some of the lymphoma cells showed plasmacytoid differentiation. Immunoperoxidase study showed intracytoplasmic polyclonal immunoglobulins in non-neoplastic plasma cells around the colonic carcinoma, in the bone marrows, and spleen. However, neither IgM nor lambda light chain was found in the cerebral lymphoma cells. The source of the macroglobulinemia in this case was discussed.

Adenocarcinoma↗
PubMed1981

Therapy for urolithiasis with hydroxamic acids. IV. Prevention of infected urinary stone formation with N-(pivaloyl)glycinohydroxamic acid.

With the aim of finding a prospective therapeutic compound with a promising potential for the treatment of urolithiasis, we evaluated the effectiveness of a new potent inhibitor of urease, N-(pivaloyl)glycinohydroxamic acid. The present study revealed that N-(pivaloyl)glycinohydroxamic acid effectively inhibited the alkalinization of urine and the stone formation in vitro and in vivo, due to its strong inhibitory potency against the ureolytic activity of intact Proteus mirabilis. The possibility of the clinical application of this compound in the prevention of struvite stone formation caused by infection of urea-splitting bacteria awaits evaluation of the safety of this compound.

Animals↗
PubMed1981

A cyst-forming Eimeriina found in the kangaroo imported from Australia.

One pair of grey kangaroos was imported from Australia in July 1974. One month after arrival they successively died of serious intestinal bleeding. On biopsy, the epithelium was destroyed and replaced with necrotic degeneration with numerous dot-like flecks of bleeding from the stomach till the jejunum. On histopathological examinations, the epithelium was composed of swollen glandular cells which form giant cells with eccentrically displaced nuclei. The cell forms a cyst which develops solitarily and gathers together to form a racemous shape. These cysts are bound to the thick wall and the parasites are found in the vesicular space. Several sequences of the parasite growth are demonstrated. The parasites migrated initially into the cytoplasm and then to the nucleus of the glandular cell in which they grow, then the cyst is formed and finally the parasites flow out to penetrate again into normal cells. The parasite cell changes to crescent- or spindle-shape as a tachyzoite. The relative nucleic acid content of the parasite in the host cell or its nucleus is measured by spectrophotometry and fluorometry. The data suggest that the parasites are reproduced in intestinal glandular cells of the kangaroo.

Animals↗