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Biomedical subjects

H Tellkamp

Publications and source records attributed to H Tellkamp.

At least 19 recordsLinked to original sources

[Encephalopathy in leukemia treatment in children].

Side effects on the central nervous system by antileukemic treatment have been well known for a long time. We report on 2 patients suffering from a severe encephalopathy during antileukemic therapy. Furthermore the results of cerebral computer tomography in 50 children with acute leukemia have been analysed. In 21 patients morphological findings were evident. Four patients had CCT-changes already before the beginning of their treatment. Initially in 2 patients leukemic cerebral infiltrations were detected. The importance of the computer tomography for the detection of cerebral affections by disease and treatment is demonstrated.

Antineoplastic Combined Chemotherapy Protocols

[Frontonasal dysplasia. Case report and review of the literature].

FND is a non-uniform malformation complex with symptoms ranging between severe hypertelorism with bidfid nose and cranium bidfidum occultum with agenesis of the corpus callosum. Etiology and pathogenesis are discussed on the basis of a case history and some hints regarding differential diagnosis and genetic counselling are given. The exclusively sporadic occurrence of FND tells against a hereditary pathomechanism. Consequently, there is no recurrence risk. However, in families with an affected child, malformations generally tend to occur a little more often.

Abnormalities, Multiple

[Radiogenic pneumopathy in irradiated breast cancer--a follow-up assessment based on chest radiographs].

In 232 surgically treated and irradiated patients with breast carcinoma 27 cases of radiogeneous pneumopathia were found and analyzed in the chest radiograph. Special attention was given to the evaluation of the stage and the course of the radiation pneumonitis. No correlation between clinical results and x-ray symptoms was seen. Not every roentgenologically diagnosed pneumonitis is seen in the late follow-up as a fibrosis. The reasons for this are discussed. For the improved detectability of pneumonitic changes in the p.a. or lateral image no significant differences were found and no general rules. Additional CT-investigations of the chest demonstrated the radiogeneous lung changes more clearly and more exactly in its depths. Therefore an exact use of CT in the diagnostics of pneumonitis can be useful, but must be seen under the aspects of relevant therapy the availability of methods and economy.

Adult

[Computed tomographic measurements of breast density].

From histogram analysis the value of computed tomography for early detection of breast carcinoma or differentiation of benign and malign processes of the breast was evaluated. The results show, that CT is not applicable and gives no improvement of diagnostics.

Breast Neoplasms

[Diagnostic strategy in pancreatic tumors].

In 62 patients with proven pancreatic tumours in a joint retrospective study the sequence of diagnostic imaging methods was analysed. Their diagnostic value was evaluated according to their contribution to final diagnosis and a diagnostic strategy was derived. A valuable primary investigation is sonography. It should be complemented, according to the specific question, by ERCP, PTC and CT. The investigation with barium meal is a complementing method for the differentiation of epigastric disorders. Biopsy of the tumour for histologic purposes should be done as early as possible. A first guiding diagnosis was obtained with ultrasound in 50% of the cases, in 53% of them already with the first examination. In 23% of the patients, however, the final diagnosis was established not before surgery or dissection.

Cholangiopancreatography, Endoscopic Retrograde

[The strategy of new imaging procedures in the diagnosis of malignant bone processes].

From the comparison of conventional radiography, computed tomography and angiography the diagnostic value of each of these methods is evaluated. Conventional radiography will remain the most significant method for detecting primary skeletal tumours even if magnetic resonance imaging is considered. CT is an important additional method for the evaluation of tumour size, but is disappointing for tumour classification. Bone scintigraphy is the most sensitive method for the differentiation of solitary and multiple tumours. Angiography is not necessary, except for the planning of surgery in certain cases.

Angiography

[The use of CT in meniscopathy].

The results of CT examination of meniscopathies in 54 patients, most of them competitive athletes, are presented. CT has an overall accuracy of about 90 per cent and can hence be used for diagnosing a lesion of the meniscus with a reasonable amount of safety, while being rapid and avoiding unnecessary exposure to stress. This method, therefore, should be a focal point of the imaging methods and thus be placed between the specialist doctor's findings and possible surgery. The pros and cons of CT compared with other imaging methods are discussed.

Athletic Injuries

[Value of computerized tomography in paranasal sinus osteoma].

An example of a frontal ethmoidal osteoma of extreme dimensions in a juvenile of 16 years of age is discussed. We are studying the question whether preoperative diagnosis via CT can supply pointers to the involvement of neighboring tissue structures.

Adolescent

[Computed tomography changes during radiotherapy of intracranial tumors].

722 CT examinations were carried out in 178 patients having intracranial tumours. The CT changes resulting from radiotherapy have been analysed. The examinations were performed at the beginning of treatment, after 30 and 50 Gy, after a three months' pause and at the conclusion of the planned total irradiation with 70 Gy. The results indicate that CT of intracranial tumours is an excellent method of demonstrating the effect of treatment. Information regarding the surroundings of the tumour (eg. cerebral oedema, displacement, herniation, compression of the ventricular system etc.) may be as important as that concerning the tumour itself. For evaluating the effect of radiation therapy, measurements of the size of the tumour are much more informative than density measurements. Even after 30 Gy, there was a change in tumour size in 49% of patients. Planned CT control used in conjunction with clinical information provides an effective means of adapting treatment to the changes in the tumour.

Adult