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Biomedical subjects

H Thom

Publications and source records attributed to H Thom.

At least 37 records · Page 2Linked to original sources
PubMed1982

Fat as an energy supplement for preterm infants.

The absorption and utilisation of dietary fat as an energy supplement was studied in 15 healthy preterm infants. They were given two formulae for periods of one week. The standard low solute feed supplied 6 g fat and 476 kJ (114 cal) per kg. The high energy feed supplied 10 g of the same fat and 623 kJ (149 cal) per kg. Fat supplementation resulted in increased absorption (significantly higher chylomicron levels) without steatorrhoea or metabolic disturbance, apparently unchanged differential absorption of fatty acids, and a significantly higher rate of weight gain (mean 25.9 +/- 4.6 compared with 20.3 +/- 4.4 g/24 h). A high energy formula prepared with supplements of complex dietary fat is therefore of potential value in ensuring the adequate nutrition and growth of preterm infants.

Animals↗
PubMed1977

Fetal proteinuria in diagnosis of congenital nephrosis detected by raised alpha-fetoprotein in maternal serum.

High concentrations of alpha-fetoprotein (alpha-FP) were found at 14, 19, and 21 weeks gestation in the serum of a woman with a history of unexplained fetal death in her previous pregnancies. The alpha-FP concentration of the liquor also was high at 21 weeks and the pregnancy was terminated. Though the fetus was macroscopically normal, measurement of albumin, alpha-FP, IgG, and alpha2-macroglobulin in the fetal urine showed a selective proteinuria, and congenital nephrosis was diagnosed after examination of the fetal kidneys by electron microscopy. Possibly some fetuses reported to be "false-positive for neural tube defect" may have had renal lesions of this nature. Examination of fetal urine may be the simplest initial diagnostic procedure in any future case.

Adult↗
PubMed1975

Palmitic acid concentrations and lecithin/sphingomyelin ratios in amniotic fluid.

Palmitic acid concentrations and L/S ratios have been estimated in amniotic fluid specimens with and without centrifugation and cold acetone precipitation. Although the number of cases was small, both of these measurements in uncentrifuged fluid seemed to reflect only indirectly on lung maturation in normal pregnancy while with centrifuged fluid the L/S value predicted RDS in one infant more reliably than palmitic acid concentration.

Acetone↗
PubMed1975

Prenatal diagnosis and family studies in a case of propionicacidaemia.

In a family with a history of two neonatal deaths, propionicacidaemia was diagnosed retrospectively from stored plasma as the cause of the second death during the mother's next pregnancy. Amniocentesis was performed and a culture of amniotic cells was assayed for propionyl CoA carboxylase activity. The absence of any detectable propionyl CoA carboxylase activity allowed the prenatal diagnosis of propionicacidaemia to be made. Treatment with biotin and a modified aminoacid diet was started in the immediate postnatal period. Investigation of propionyl CoA carboxylase in leucocytes from the parents, siblings and other relations of the patient failed to demonstrate intermediate enzyme activities in even the parents, who were presumably heterozygotes for this condition.

Amino Acid Metabolism, Inborn Errors↗
PubMed1975

The origin of amnitoic fluid lecithin.

Lecithin has been measured in amniotic fluid, pharyngeal aspirate, fetal and maternal plasma and fetal membranes from the same pregnancy. In the amniotic fluid from a term pregnancy 79 per cent of the lecithin is found in the reconstituted precipitate of centrifuged fluid. It is suggested that the lecithin of amniotic fluid may originate from sources other than fetal lung and that lecithin concentration is therefore a measure of overall fetal maturity.

Amniotic Fluid↗
PubMed1974

A comparison of stool fluid and stool dialysate obtained in vivo.

Stool fluid has been obtained for analysis by homogenization and high speed centrifugation of fresh stool. This fluid, from two healthy individuals with soft stools has been compared with stool dialysate obtained in vivo by retrieval of swallowed dialysis bags from their stools. Stool fluid was more acid, with a higher osmolality, an increased concentration of organic anions, sugar and ammonia, and a lower bicarbonate concentration than dialysate in vivo. It is suggested that in the individuals studied, dialysate in vivo may not be in equilibrium with the stool fluid surrounding it, and may not represent a true dialysate of faecal water.

Adult↗