Biomedical subjects

H Tobón

Publications and source records attributed to H Tobón.

3 recordsLinked to original sources

PubMed1991

Primary clear cell carcinoma of the endometrium: a clinicopathologic study of 20 cases.

Primary clear cell adenocarcinoma of the endometrium (CCE) is a rare, aggressive tumor, representing 1-5.5% of all primary endometrial cancers. Twenty cases of CCE were studied, covering the period 1973-1987. Both endometrial curettings and hysterectomy with bilateral salpingo-oophorectomy (BSO) specimens were reviewed. Treatment was total abdominal hysterectomy/BSO for all patients with/without pre- and postoperative and/or post-operative chemotherapy. Grossly the tumors formed fleshy, soft masses and involved most of the endometrial surface. The tumor arose in part in an endometrial polyp in 10 cases. Myometrial penetration was found in 12 cases and varied from 5 to 100%. The neoplasm exhibited the following microscopic patterns in pure form or mixed: papillary, tubulocystic, glandular, and solid. All cases were graded as poorly differentiated (grade 3) adenocarcinomas. The stroma surrounding tumor cells showed a lymphoplasmocytic cellular infiltrate in all cases. Follow-up varied from 5 to 165 months, with a crude survival of 60%; eight patients died; six of those had myometrial invasion of 40-100%. In conclusion, CCEs are specific tumors with defined histologic parameters in which the cytologic grade and/or tumor morphology do not appear to influence outcome. On the other hand, the depth of myometrial invasion and clinical staging are reliable prognostic elements.

Adenocarcinoma↗

PubMed1988

Adenocarcinoma in situ of the cervix. Clinicopathologic observations of 11 cases.

Adenocarcinomas in situ (AIS) of the cervix represent less than 1% of all primary adenocarcinomas of the cervix; 11 cases from the Magee-Women's Hospital (1969-1984) are described. The patients' ages ranged from 25 to 81 years (average 48.5 years). One patient was nulliparous and the others had one to five children. The most common presenting symptom was postmenopausal or other abnormal vaginal bleeding. The AIS were diagnosed as follows: a positive, suspicious, or dysplastic Pap smear in seven cases; in three, the AIS was an incidental finding during a hysterectomy; and one case was diagnosed in an endocervical curettage. Most of the AIS were in or near the transformation zone, having two distinct histologic glandular patterns with tall columnar or large ballooned cells (Types I and II respectively). In three cases an associated in situ squamous cell carcinoma or severe dysplasia of the cervix was seen. Two patients had associated well-differentiated adenocarcinoma of the endometrium and a third had endometrial hyperplasia. One lesion stained strongly positive for carcinoembryonic antigen and all others were negative. Eight patients underwent total abdominal hysterectomy and bilateral salpingo-oopherectomy (TAH-BSO), two had total abdominal hysterectomy (one with salpingo-oophorectomy), and one 25-year-old was treated by deep conization only. All patients, except one who died with associated adenocarcinoma of the cecum, were alive 8 to 127 months after treatment.

Adenocarcinoma↗

PubMed1987

Vaginitis emphysematosa.

Vaginitis emphysematosa is rare, as only 173 cases, to our knowledge, have been reported in the English literature, the last in 1967. We report three new cases and bring the subject up to date. The ages of our patients ranged from 42 to 65 years; one patient complained of vaginal discharge, and the other two cases were found on routine examination, one at autopsy for breast carcinomatosis. The lesions were described as nodules in the vagina, on occasion producing a "popping sound" that relieved the pressure sensation. Microscopically, variably sized cysts were seen containing pink hyalinlike material and foreign body-type giant cells in the cyst's wall, accompanied by minimal chronic inflammatory cell infiltrate. Vaginitis emphysematosa is an uncommon self-healing disease of unknown cause that produces no sequelae deleterious to the patient.

Adult↗