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Biomedical subjects

H Toft

Publications and source records attributed to H Toft.

17 recordsLinked to original sources
PubMed2001

[Hyperhomocysteinemia and hypothyroidism].

Moderate hyperhomocysteinaemia is associated with hypothyroidism. Increased levels of homocysteine might contribute to a greater cardiovascular risk. This paper reports a case of transient myxoedema, owing to postpartum thyroiditis. The fluctuation of P-homocysteine was inversely correlated to the free thyroxine index. We recommend TSH screening of patients with unexplained hyperhomocysteinaemia.

Abortion, Induced↗
PubMed2001

Remission of nephrotic-range albuminuria in type 1 diabetic patients.

OBJECTIVE: To evaluate the cumulative incidence of nephrotic-range albuminuria (NRA), the frequency of remission, and the impact on progression, we analyzed data from a prospective cohort study of type 1 diabetic patients with diabetic nephropathy. RESEARCH DESIGN AND METHODS: All of the albuminuric type 1 diabetic patients (n = 321, 121 women), who had at least yearly measurements of glomerular filtration rate (GFR) with a (51)Cr-EDTA plasma clearance technique and were followed for at least 3 years, were evaluated. NRA, defined as persistent albuminuria >2,500 mg/24 h, occurred in 126 patients (35 women) aged (mean +/- SD) 34 +/- 8 years, with duration of diabetes 22 +/- 8 years and follow-up time from onset of NRA (median [range]) 8.7 (3.0-20.9) years. Remission of NRA was defined as sustained albuminuria <600 mg/24 h for at least 1 year. RESULTS: The cumulative incidence of NRA was 39%. Remission was induced in 28 of 126 (22%) patients; 21 were predominantly treated with ACE inhibitors, 7 with non-ACE inhibitor medications. Remission lasted 3.6 (1.0-18.1) years. More women (37%) than men (16%) obtained remission (P = 0.01). In the remission group compared with the no-remission group, mean arterial blood pressure (mean +/- SEM) was reduced (102 +/- 1 vs. 106 +/- 1 mmHg, P < 0.01), the rate of decline in GFR was diminished (3.8 +/- 0.6 vs. 7.5 +/- 0.5 ml x min(-1) x year(-1), P < 0.001), and serum cholesterol was lower (5.3 +/- 0.2 vs. 6.1 +/- 0.1 mmol/l, P < 0.01) during the whole follow-up period. No difference in glycemic control was found between groups (HbA(1c) 9.2 vs. 9.4%, NS). CONCLUSIONS: In contrast to observations made before the use of antihypertensive treatment, our prospective observational study suggests that aggressive antihypertensive treatment with and without ACE inhibitors can induce long-lasting remission in a sizeable fraction of type 1 diabetic patients with NRA. The group of patients obtaining remission is characterized by slow progression of diabetic nephropathy and improved cardiovascular risk profile.

Adult↗
PubMed1989

[Hypothyroidism and coronary artery bypass surgery].

A hypothyroid patient with severe coronary disease is described. Coronary artery bypass was undertaken without preoperative treatment with thyroid hormone. Coronary artery bypass surgery may be undertaken in hypothyroid patients without significant risks. As a rule, preoperative administration of thyroid hormone should be omitted on account of the risk of aggravating the ischaemic cardiac condition. Treatment with L-thyroxin is instituted rapidly postoperatively and, in the great majority of cases, it is possible to obtain complete thyroid hormone substitution therapy after coronary revascularisation has been performed. It is emphasized that all middle-aged women with raised serum cholesterol should be screened for myxoedema even if they do not appear to be hypothyroid clinically.

Aged↗
PubMed1971

Effect of frusemide administration on calcium excretion.

Each of eight adipose but otherwise normal patients on a reducing diet received daily oral doses of frusemide for four days; the degree of hypercalciuria was found to be significant during the first three days, but on day four the calcium excretion in the urine had become normal though frusemide was still being given. The rates of excretion of sodium and calcium in the urine were closely correlated.

Calcium↗