[Acute urticaria induced by piroxicam].
A case of acute urticaria provoked by piroxicam is reported. Diverse types of cutaneous reactions by this drug have been described.
Biomedical subjects
Publications and source records attributed to H Torras.
A case of acute urticaria provoked by piroxicam is reported. Diverse types of cutaneous reactions by this drug have been described.
The authors summarize their experience in the treatment of recurrent, necrotic and giant mucocutaneous aphthosis (9 cases) and Behçet's disease (9 cases) with Thalidomide during four years. In recurrent mucocutaneous aphthosis the results were very good, with fast disappearance of pain, healing of the ahthae and disappearance or delay of recurrence. The result in Behçet's disease is similar, possibly less, in mucocutaneous lesions. Uveitis also reacts favorably but we can not say that the results were superior to those obtained by other drugs (corticoids, cytostatics immunosuppressives), although its side effects are less. On the other hand it does not appear to have any effect on other symptoms such as arthritis (in which colchicine is active), thromboflebitis or fever. There is not sufficient experience to judge its action on neurological symptoms. The recommended dose is 100 mgr./day for 10 days, a higher dose does not appear to give better results. Patients who have received treatment several times appear to have the same results, but slower. Neurotoxicity has not been observed and the only side effect which has been noted is digestive intolerance in two cases, after which the medication was stopped. The authors consider that Thalidomide, with due precaution, which must be scrupulously determined, is the most active medicament in particularly severe cases with profusion of necrotic aphthae, mutilating and recurring mucocutaneous aphthosis, also being useful in controlling some symptoms of Behçet's disease.
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Postovulation Dermatitis is a frequent clinical picture although it is not well known. Clinically a polymorphous eruption appears between than 8 or 10 day before menses. The Authors report three cases in which an complete immunological investigation was performed. They conclude that there is no objective evidence of the autoimmune pathogeny of this picture in spite of the clinical relationship between the dermatitis and the ovulation. Therefore they suggest that diseases should be described as "Postovulation Dermatitis" instead "Autoimmune Progesterone Dermatitis".
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A case of contract sensitization to the ethylene oxide by a mask sterilized with this substance is reported. The mask was correctly sterilized but the ethylene oxide was not completely evaporised. The path tests were positive in the patient but negative in 25 control subjects. The patch tests with the international series and with all the elements of the mask were negative. The possible troubles of ethylene oxide and the sterylisation methodes of this substance are reviewed.
A case of mastocytosis is presented by the authors. The lesions appeared in early childhood with the typical appearance of urticaria pigmentosa. With the course of the years they changed becoming micropapular and assuming the appearance of the clinical picture described by Griffiths and Daneshbod as pseudoxantomatosis mastocytosis, although some clinical and histological aspects resembled the morphology and structure of the "nevus elasticus".
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