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Biomedical subjects

H Tschabitscher

Publications and source records attributed to H Tschabitscher.

At least 19 recordsLinked to original sources
PubMed1986

[Gamma globulin therapy in multiple sclerosis. Theoretical considerations and initial clinical experiences with 7S immunoglobulins in MS therapy].

The number of reports about successful therapeutical application of 7S-immunoglobulins in various auto-immune diseases such as ITP or autoimmune neutropenia or in myasthenia gravis has increased in recent years. Multiple Sclerosis (MS) is an inflammatory demyelinating disease, in which antibodies directed against various components of the myelin sheath play an important pathogenetic part. Increased antibody dependent cytotoxicity has been reported in MS, and myelinotoxic antibodies and a myelination inhibiting factor have been found in acute cases. Lately several authors have tested 7S-immunoglobulins in the treatment of MS. It is still too early for final judgement of the therapeutical efficacy, however, patients suffering from the progressive form of MS with exacerbations showed rather fast improvement of their latest neurological deficits, when treated shortly after a fresh bout. Mechanisms of action which should be taken into consideration include reduced antibody dependent cytotoxicity by surface receptor blocking reduction of the number of circulating myelinotoxic antibodies caused by a negative feed back mechanism, and removal of a neuroelectric inhibiting factor caused by antibodies.

Autoantibodies↗
PubMed1985

[Apolipoproteins A and B in cerebrovascular diseases].

The present study has proved unequivocally the value of determining apolipoproteins A and B and the APO-L A/B quotient for establishing the risk for cerebrovascular disease. The determination of apolipoproteins should be preferred to the determination of HDL, LDL and VLDL, which has been practised so far. While only 30% of a group of 88 patients suffering from cerebrovascular disease had serum cholesterol levels of more than 250 mg/dl and approx. 57% showed HDL values below 40 mg/dl, a reduced APO-L A/B relation (less than 1.75) was demonstrated in 74%. A reduced APO-L A/B quotient was also observed in more than 70% of 62 CVD patients whose cholesterol level was within the range of normal. Determination of apolipoproteins may, therefore, be regarded as further progress in risk factor diagnostic of arteriosclerotic disease.

Adult↗
PubMed1980

[Management and relapse prophylaxis of cerebral transitory ischemic attack (TIA) (author's transl)].

The paper gives a definition of the clinical concept of TIA, pointing out that the difference between TIA and ischemic brain infarction is not a qualitative but a quantitative one. Anatomy, physiology and metabolism of the brain will be discussed and clinical symptoms of TIA in the supply areas of the carotid and the vertebro-basilar arteries will be presented. Pathogenetic factors of TIA mentioned are: cardiac embolism, intravascular microembolism within the framework of cerebrovascular arteriosclerosis and alterations of blood composition, intracerebral steal mechanism, especially in cases of decreased systemic blood pressure and collateral circulation in stenotic or thrombotic vascular diseases. The paper stresses the importance of early diagnosis of TIA in view of the fact that approx. 30% of TIAs are not only followed by recurrent episodes but also develop into brain infarction. Clarification of the pathogenesis by appropriate examinations and causal therapy are therefore of particular importance. The significance of anticoagulant therapy, platelet aggregation inhibitors and cardiac therapy will be stressed and possible surgical management, especially the surgical bypass, will be presented. The curative and preventive effect of these forms of treatment will be evaluated.

Humans↗
PubMed1978

[Lactacidosis of the cerebrospinal fluid in apoplexy as indicator of prognosis (author's transl)].

Blood and CSF gases, as well as the level of lactate and pyruvate in blood and CSF were determined in 43 cases. of severe stroke with softening of the brain. It transpired that the CSF lactate level is the best prognostic indicator of survival. CSF values above 2,5 mMol/1 in apoplexy imply a very unfavourable prognosis. The CSF lactate level is also a very useful prognostic indicator in patients suffering from diabetes and/or uraemic metabolic disorders. As the determination of CSF lactate presents no tecnical difficulties and furnishes valuable prognostic information it would merit inclusion as a routine procedure in relevant cases.

Acidosis↗