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Biomedical subjects

H Tuppy

Publications and source records attributed to H Tuppy.

At least 19 recordsLinked to original sources
PubMed2000

[Primary epithelioid angiosarcoma of the proximal trachea].

A 81-year-old man presented with massive hemoptysis and dyspnea. Results of chest radiography and computer tomography were highly suspicious for a large right-sided tumor of the bronchus with impression of the right main bronchus. Because of clinical worsening the patient was transferred to our department of pulmonology. The patient died of unappeasable hemoptysis the next day. At autopsy we found a 2-cm-diameter tumor of the proximal trachea as the source of massive bleeding and blood aspiration. Histological examination confirmed the tumor to be an epithelioid angiosarcoma of the trachea, which was a primary as no other tumor manifestation was detected. The entity of epithelioid angiosarcoma as a primary tumor of the trachea, to our knowledge, has not yet been reported.

Aged↗
PubMed2000

Idiopathic enterocolic lymphocytic phlebitis: a rare cause of ischemic colitis.

We report on a 74-year-old female patient who was admitted to the hospital because of abdominal pain. She underwent a colonoscopy and a stenosing mass was found in the cecum. Histologic findings in the biopsy specimens were consistent with ischemic colitis. Due to clinical symptoms and the endoscopic and radiologic findings that roused the suspicion that the patient was suffering from a malignant tumor, a right hemicolectomy was performed. Histology of the resection specimen disclosed an inflammation of the veins. It was characterized by a predominantly lymphocytic infiltration of the vessels affecting the veins of the colonic wall and the mesentery. Furthermore, secondary thrombosis with focal venous occlusion was observed. The colon showed extensive ischemic colitis with focal transmural coagulation necrosis. The disease was considered to be idiopathic lymphocytic phlebitis, which is a rare disease of unknown origin. Our patient is well and alive after more than 1 year, supporting the notion that the disease shows a benign course after surgery.

Aged↗
PubMed1999

[Angioleiomyoma of the gallbladder: a rare cause of hemobilia in a patient on dialysis].

HISTORY AND FINDINGS: Acute colicky upper abdominal pain occurred in a 47-year-old man on renal dialysis who also had chronic recurrent pancreatitis. On physical examination he was noted to be slightly jaundiced and he had slight pain when the liver edge was palpated. A few days later melaena developed and the haemoglobin concentration fell from normal levels to 6.9 g/dl. INVESTIGATIONS: Serology gave no evidence of acute pancreatitis, but biochemical tests indicated cholestasis. Ultrasonography revealed widening of the intra- and extrahepatic biliary tract. Endoscopic retrograde cholecystopancreatography demonstrated bleeding from the biliary tract (haemobilia) as the source of the bleeding. Selective angiography of the coeliac trunk showed extravasation in the region of the gallbladder. TREATMENT AND COURSE: As a vascular anomaly in the gallbladder was suspected, a cholecystectomy was performed. The surgical specimen revealed an angioleiomyoma of the gallbladder. The postoperative course was without complications and there was no further haemobilia. CONCLUSIONS: Haemobilia is a relatively rare cause of upper gastrointestinal bleeding. It is usually due to trauma (accidental or iatrogenic) to the liver or the biliary tract. Rarely, as in this case, it can be caused by a benign mesenchymal neoplasm. Clotting disorder in uraemia or intermittent heparin administration for dialysis may in this patient have contributed to the bleeding.

Angiomyoma↗
PubMed1998

[Tropical sprue as the cause of chronic diarrhea after travel to Southeast Asia].

A 43-year-old woman developed abdominal pain and diarrhea following a travel to Malaysia. Examinations in another hospital proved no evidence of infection, an empirical antibiotic therapy with ciprofloxacin yielded no benefit. One and a half year later, the patient was admitted to our department because of persistent diarrhea and wasting. Laboratory tests showed megaloblastic anemia, folate deficiency and steatorrhea. Stool specimens for bacterial pathogens and parasites were negative. Endoscopy and biopsy from the distal portion of the duodenum revealed broadening and shortening of the villi and an increased infiltration of the lamina propria by chronic inflammatory cells (plasma cells and lymphocytes). In conclusion, diagnosis of tropical sprue was established. The therapy comprised of tetracycline for six weeks and folic acid for six months. Subsequently, the diarrhea disappeared, the patient continuously gained weight and was free of any complaints. The complete remission following this regimen proved the suspected diagnosis. Differential diagnosis in any patient who recently returned from the tropics may be a challenge. Tropical sprue predominantly occurs during or after a longer stay in endemic areas. However, if chronic diarrhea and signs of malabsorption develop after a short journey to India, South-East Asia and parts of the Caribbean, tropical sprue has to be considered, too.

Adult↗
PubMed1980

Increase of blood group A and loss of blood group Sda activity in the mucus from human neoplastic colon.

Aqueous extracts of human neoplastic and adjacent normal colonic mucosa were investigated for hemagglutination inhibition of both the anti-A serum and the Dolichos biflorus lectin. The anti-A antiserum was inhibited by the extracts from neoplastic tissues to a much higher extent than by that from normal mucosa; the inhibition was strictly dependent on the blood group and the secretor status of the individual. The inhibition titers against the Dolichos lectin were much lower for the tumor than for the normal tissue and the inhibition of this lectin was not dependent on blood group and secretor status. In addition, studies on the specificity of both agglutinins showed that only the anti-A antiserum reacted with the blood group A antigen in the colonic mucus whereas the Dolichos lectin reacted with a different substance which was not related to the blood group ABO system. The Dolichos reactive mucin was isolated by gel chromatography and by affinity chromatography on Dolichos-Sepharose. The partially purified mucin did not show any blood group A or H activity but reacted with all GalNAc specific lectins tested. A very high specific activity was obtained against the Dolichos biflorus lectin whereas the agglutinins from Salvia sclarea, Glycine max. (soybean) and Helix pomatia were less strongly inhibited no matter whether blood group A1, Tn, or Cad erythrocytes were used. By far the highest inhibitory activity was found against the human anti-Sd(a) antiserum regardless of whether the red blood cells were Cad or Sd(a+). By gel chromatography an equally pure mucin fraction could be obtained from neoplastic tissues which did not bind to either the anti-A antiserum nor the GalNAc specific lectins but could inhibit the anti-Sda antiserum at a far lower specific activity than the normal preparation.

ABO Blood-Group System↗
PubMed1978

Enzymatic synthesis of blood-group Lewis-specific glycolipids.

A blood-group Lewis precursor glycolipid was isolated from the plasma of a Lewis-negative individual [Le(a--b--)] and treated with fucosyltransferases from human gastric mucosa and GDP-fucose. Subsequently the glycolipid was adsorbed onto Le(a--b--) erythrocytes and the presence of blood-group Lewis antigens was assessed by passive hemagglutination with anti-Lewis sera. It was shown that the precursor glycolipid was enzymatically transformed to blood-group Lewis a (Lea) and Lewis b (Leb) specific glycolipids. Leb-glycolipid was also synthesized by fucosylation of an isolated Lea-glycolipid. Moreover Le(a--b--) erythrocytes were shown to develop Lea and Leb activities when subjected to enzymatic fucosylation, thus showing that Lewis-negative cells carry blood-group Lewis precursor glycolipid on the surface of their membrane. Le(a + b--) erthrocytes, upon enzymatic fucosylation, acquired Leb activity.

Epitopes↗
PubMed1977

Differences between Adenosine Triphosphatases from Monocotylous and Dicotylous Plants.

The mitochondrial membrane-bound ATPases of several plants were investigated. Two distinct types were encountered. The mitochondrial ATPases of castor bean (Ricinus communis var. Zanzibarensis, L.), cauliflower (Brassica oleracea, L.), and scarlet runner (Phaseolus coccineus, L.) were found to be inhibited by oligomycin, to have elevated molecular weights when separated from the organelles by ultrasonication and ammonium sulfate treatment and, subsequent to purification, to be cold-labile. On the other hand, mitochondria isolated from wheat (Triticum aestivum, L.), maize (Zea mays, L.), calla (Zantedeschia aethiopica, Spreng.), and onions (Allium cepa, L.) contain ATPases which, after ultrasonication of the organelles, were virtually insensitive to oligomycin and those molecular weights were as low as about 45,000; in the purified form they were resistant to storage in the cold. The plants whose mitochondria were of the first type, characterized by having ATPases similar to those of the mitochondria of animal tissues and bakers' yeast, belonged to the dicotyledons, whereas the mitochondria of the other type were found in monocotyledonous plants.

Journal Article↗
PubMed1976

A low-molecular-weight ATPase from wheat-seedling mitochondria.

An ATPase which strikingly differed from the mitochondrial ATPases of yeast and of animal tissues was obtained when wheat seedling mitochondria, or electron transport particles derived from them, were subjected to ultrasonication and treated with ammonium sulphate. The enzyme which was purified by chromatography on Sephadex G-100 and DEAE-Sephadex (A50) failed to be inactivated as low as 43 000. The enzyme preparation was capable of hydrolysing ADP, in addition to ATP, and several other nucleoside diphosphates and triphosphates. In contrast to the ATPase of animal mitochondria, the activity of the wheat enzyme was almost as insensitive to oligomycin in intact mitochondria as it was after isolation from the organelles.

Adenosine Triphosphatases↗
PubMed1976

[Synthetic low-molecular weight interferon inducers: derivatives of diaminofluoren-9-one, diaminobenzophenones and diamino biphenyls].

Among the aminoacyl derivatives of 2,7-diaminofluoren-9-one a few compounds were found capable of inducing interferon in the mouse when administered perorally. One of them, 2,7-bis[(diethylamino)acetylamino]fluoren-9-one exhibited an inducing activity comparable to that of 2,7-bis-(2-diethylaminoethoxy)-fluoren-9-one (tilorone). The synthesis of derivatives of fluorene, fluorenol, fluorenone, diaminobenzophenone, diaminiodiphenylmethane and benzidine, all of them with corresponding side chains, allowed to establish structural requirements for interferon inducing capability.

Amides↗
PubMed1975

Action of glycosyl transferases upon "Bombay" (Oh) erythrocytes. Conversion to cells showing blood-group H and A specificities.

Individuals of the rare "Bombay" (Oh) blood-group phenotype lacking, due to a genetic defect, the alpha(1-2)fucosyl transferase, which is responsible for converting blood-group H precursor substances to H-specific structures. Treatment with GDP-fucose and alpha(1-2)fucosyl transferase prepared from gastric mucosa of O individuals to transform native or ficin-treated "Bombay" erythrocytes into cells phenotypically resembling O cells. The transformation was achieved, however, after prior incubation of the "Bombay" erythrocytes with neuraminidase, indicating that blood-group H precursor molecules on the surface of these cells are masked by sialyl residues. Blood-group A specificity was conferred upon neuraminidase-treated "Bombay" cells by enzymatic transfer of alpha-N-acetylgalactosamine residues, in addition to alpha-fucose residues.

ABO Blood-Group System↗