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Biomedical subjects

H U Langendorff

Publications and source records attributed to H U Langendorff.

10 recordsLinked to original sources
PubMed1992

[Synthetic replacement of the anterior cruciate ligament--effects on the remaining ligament structures].

In a three-dimensional anatomical knee joint model all major ligaments were replaced by six nylon fibers and length-pattern changes registered and computed during motion between 0-140 degree. Then anteromedial, posteromedial and intermedial fibers were replaced by an artificial ligament made from Aramid (one to three bundle prothesis) and length changes of the remaining ligaments investigated. The result revealed a dynamic feed-back with characteristic changes in the posterior and collateral ligaments in comparison to the reference. A synthetic replacement using a one bundle prothesis in the isometic tracking led to disapointing results. Best correlations were achieved mimicking the anatomic situation by use of a three bundle prothesis with nearly no changes in the length pattern of the remaining ligaments.

Anterior Cruciate Ligament↗
PubMed1991

[Computer-assisted data analysis of injuries of the skeletal system in polytrauma patients].

The data of 366 patients with multiple injuries were evaluated by application of data processing over a period of seven years. Age and sex distribution, location and combination of injuries, mortality, mechanism of accident, diagnostics as well as therapy were analysed. 91.3% of our patients had injuries of the skeleton. The male to female ratio was 2:1. In 55.4% the age of the patients ranged from 10 to 39 years. The mortality rate of all patients was 27.2%. In the third decade only 16.9% of the patients died. Whereas the mortality of the patients in the 1. decade as well as between the 7. and 9. decades of life was very high (33% and 50%). Most of the skeletal injuries were located in the shank (24% open fractures). The mortality rate increases with the number of injuries (Table III). Patients with concomitant injuries, such as head injuries and fractures of the extremities were the most common combination of multiple injuries. 20% of the patients in this group died. Patients with combined injuries of the head, chest, abdomen and skeleton had highest mortality (57%). X-ray examination of the skull, chest, extremities and mainly of the spine and pelvis should be subjects of routine diagnostics. In patients who were suspected of having a blunt abdominal trauma, the first diagnostic technique will be ultrasound. On account of the various number of concomitant injuries as well as the patients individuality, the estimation of prognosis by systems for the classification of the severity of injury is fraught with difficulties. The analysis of the evaluated data showed that previously small number of variables may predict the prognosis of the course of disease.

Adolescent↗
PubMed1990

[The horizontal patellar dislocation].

The horizontal dislocation of the patella is a very rare event and little described in literature. On the occasion of a 35 years old motor car driver accident mechanism an therapeutic management are discussed.

Accidents, Traffic↗
PubMed1989

[Functional treatment of joint fractures].

The absence of functional load causes damage to different extents in various structures of the joint. Especially cartilage, joint capsule and ligaments are affected. Although operative functional treatment provides better prerequisites for avoiding such damage compared to conservative procedures, the results are not satisfactory in nearly 25% of the cases. Functional treatment of fractures of the joint by extension and continuous passive motion are suitable wherever operative reconstructions do not seem successful or have been proven to be superior as in fractures of the calcaneus.

Fracture Fixation↗
PubMed1987

[Bone cement containing cytostatic drugs: new aspects in the treatment of malignant bone tumors. I. Experimental studies].

Radical surgery in malignant bone tumors can either be limited by anatomical structures or seems inadequate in the palliative stabilization of bone metastases. Incomplete removal of the tumor and stabilization by compound osteosynthesis or endoprosthesis contains two problems: 1) the wide spread of malignant cells by manipulation in the tumor bearing area; 2) progressive destruction of bone due to remaining tumor. To overcome these problems we developed methotrexate bone cement (MTX-Palacos) with the aim to obtain high local concentrations of methotrexate in order to destroy remaining tumor cells and avoid systemic side effects. In vitro studies showed that methotrexate is released continuously from this cement without relevant changes of its biomechanical properties. Animal studies with transplanted osteosarcomas and mamma carcinomas in mice showed a considerable decrease of tumor growth when a plug of MTX-Palacos was inserted in the center of the tumor. Histological findings showed that in the surroundings of the plug the tumor was destroyed considerably contrary to normal bone cement which had no effect on the tumor at all. The results are discussed with regard to clinical application of MTX-Palacos.

Animals↗
PubMed1985

[Results of surgical treatment of fractures of the metacarpus and fingers].

Ninety-one patients with 108 fractures of the metacarpal and/or finger bones were treated by surgery between January 1974 and June 1982. 70 patients (76.9%) with 81 surgically treated fractures could be checked up after 3 3/4 years on an average. 24.3% out of these patients suffered from associated soft tissue leasions, 25.7% suffered from multiple fractures. 41 out of the 81 surgical interventions were performed for fractures of the metacarpus and 40 for fractures of the finger bones. The results were classified according to an evaluation scheme established for this purpose and containing the following parameters: mobility, trophism and sensitivity, gripping functions, force, and X-ray findings. Subjective troubles were evaluated, too. The great value of osteosynthesis in the surgical treatment of the hand is confirmed by the overall results with 92% of very good or good results and 7% of satisfactory results in metacarpal fractures and 60% of very good or good results, 36% of satisfactory results and 3% of poor results in fractures of the finger bones, the more as patients treated by surgery represent a negative selection among all patients treated for fractures of the bones of the hand. The results were classified and evaluated according to fracture site, severity of associated injuries, and method of osteosynthesis applied.

Adolescent↗
PubMed1979

[On the problem of industrial accidents under drug influence (author's transl)].

Industrial accidents resulting from technical defects have decreased in the last eights because of improved safety precautions. In contrast, accidents resulting from "human error" are increasing steadily. Toxicological urine analysis for drugs--directed mainly at soporifics, sedatives, tranquilizers, and pain-relievers--on 84 patients involved in industrial accidents yielded the following results. 1. Drugs were identified in 44 patients (= 52%). 2. In 13.4 patients, more than one drug was identified (= 16%). 3. Only five of the 44 patients admitted on being questioned that they had taken drugs (= 10%). On the other hand, in a control group of 47 persons who and not suffered any accident, drugs were detected in 19 cases (= 40%). The results show that the physician will have to take into account that healthy and efficient persons, too, are very often likely to practise drug abuse. It must be considered probable that this helps to promote accidents. Medical prescription, especially of neuroleptics and psychotropics, as well as of sedatives, should be practiced more.

Accidents, Occupational↗