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Biomedical subjects

H Ueshima

Publications and source records attributed to H Ueshima.

90 records · Page 5Linked to original sources
PubMed1984

Age specific mortality trends in the U.S.A. from 1960 to 1980: divergent age-sex-color patterns.

Trends in age-specific mortality (10-year age groups, 5-74) for the U.S. population were reviewed for all causes of death from 1960 to 1980. The age-specific mortality rate generally declined. However, the following age-sex-color groups showed divergent mortality trends compared to those of other groups: (1) The death rates for white male teenagers and young adults (ages 15-24 and 25-34) increased during 1960s and stayed at the same level during 1970s. The ratio of male to female deaths for white teenagers and young adults (15-24 and 25-34) increased over both decades, although the mortality rate for white women age 15-24 increased during the 1960s. (2) Non-white men age 15-24 and 25-34 experienced biphasic mortality trends, with a rise peaking in 1971 and then a fall. (3) The mortality ratios, non-white to white men, age 25-34 and 35-44, were far higher then those of other age groups. (4) The mortality ratios, non-white males to females, increased steadily for all age groups, and those of age groups 15-24 and 25-34 turned up sharply. Selected causes of death (1960-1977) were reviewed to uncover reasons for the unfavorable mortality trends among males. The following causes contributed to rising mortality among males: (a) accidents, suicide, and homicide for white and non-white teenagers and young adults, age 15-24, 25-34 and 35-44; (b) suicide and homicide for non-white men age 45-54; (c) cirrhosis of the liver for white men age 35-44 and for non-white 25-34, 35-44 and 45-54; (d) malignant neoplasms for white men age 35-44 and for non-white age 45-54.

Accidents↗
PubMed1984

A randomized trial on the effect of decreased dietary sodium intake on blood pressure in adolescents.

A randomized crossover trial on the effect of salt restriction on blood pressure was carried out involving 124 adolescents (mean age 16 years). Dietary sodium was reduced from approximately 110 to 45 mEq/24 h for a period of 24 days. Blood pressure was non-significantly lower at the end of the experimental diet for all participants. A slight (0.7 kg), yet statistically significant fall in weight was observed (P less than 0.05). Subgroup analysis demonstrated that participants whose body mass index was below the median had a statistically significant fall in systolic blood pressure (P less than 0.05); fall in weight and increase in heart rate were also more pronounced in the less obese individuals. It would appear that moderate sodium reduction does not have an overall short-term effect on blood pressure in normotensive adolescents. However, body size as reflected in body mass index may influence blood pressure response to sodium reduction.

Adolescent↗
PubMed1984

Alcohol consumption, blood pressure and stroke mortality in Japan.

The relationship between the national blood pressure level of an over 10,000 member representative sample of the population and alcohol consumption, using the time-series data during the period 1956-1980 was analysed. Analysis by multiple regression analysis showed alcohol consumption to be significantly related to the mean systolic blood pressure level for men independent of the treatment rate of hypertension, obesity, salt consumption and smoking rate. The relationship between alcohol consumption and stroke mortality using the age-adjusted stroke mortality for the middle-aged and alcohol consumption by prefecture (an administrative district of a province in Japan), in 1975 was also investigated. Stroke mortality for middle-aged men was highly significantly related, that for women was borderline but still significantly related, and the male:female ratio of the age-adjusted stroke mortality was also highly significantly related to alcohol intake. Thus, alcohol intake may play a role in increasing blood pressure levels and precipitate stroke, although it is possible that other confounding factors related to alcohol drinking may be related to blood pressure and also to stroke mortality.

Adult↗
PubMed1983

Family history of hypertension and red cell cation transport in high school students.

High school students who had at least one parent with hypertension (n = 22) were compared to schoolmates of the same age with a negative family history of hypertension in the parents (n = 21). We investigated in both groups the maximal rate of the ouabain-sensitive Na pump and the Na-K cotransport in nystatin-loaded cells and the Lii-Nao countertransport in lithium-loaded cells. The two groups were significantly different only in the sum of net Na transport mediated by the Na-K pump and Na-K cotransport. The mean diastolic blood pressure in the positive family history group was significantly higher. With control for blood pressure the difference in the maximal rate of Na transport was no longer significant; it remains uncertain if control for blood pressure represents "over-adjustment'. The finding of a higher maximal rate of Na transport in these adolescents who are at increased risk of future hypertension, yet currently well within the normal range, suggests that abnormal sodium metabolism may be a useful marker and appears early in the pathogenesis of this disease.

Adolescent↗
PubMed1982

Serum total cholesterol, triglyceride level, and dietary intake in Japanese students aged 15 years.

The authors surveyed serum cholesterol and triglyceride levels in 238 male and 217 female students aged 15 years in Osaka, Japan, in 1977, as well as dietary intake, using a 24-hour record in 81 male and 61 female students. Serum cholesterol and triglyceride levels of Japanese students were 163.6 mg/dl and 81.7 mg/dl, respectively, for males, and 182.2 mg/dl and 78.9 mg/dl for females. For female students, those who participated in a school sports club regularly during the previous three years had cholesterol levels 10 mg/dl lower than the subjects who had not participated in a sports club; these active students also had smaller skinfold thickness, although there was no difference in other anthropometric measurements. Although the dietary intake of Japanese students was found to be westernized, compared with that of Japanese adults, Japanese students reported low fat intake (25-30% of energy), high polyunsaturated/saturated fatty acid ratio (1.1-1.2), and high carbohydrate intake (55-61% of energy), differing considerably from US students.

Adolescent↗
PubMed1982

Dietary intake and serum total cholesterol level: their relationship to different lifestyles in several Japanese populations.

Serum total cholesterol level and dietary intake were surveyed 1975--1977 in six Japanese population groups with different lifestyles, including groups in both rural (Akita and Kochi) and urban (Osaka) areas. Clerical workers in Osaka, who had the most westernized lifestyle of all the study groups, had the highest mean serum total cholesterol level (202 mg/dl for men ages 40--49 and 50--59 years), while farmers in Akita had the lowest mean serum total cholesterol level (163 mg/dl for men 40--49 years old, 159 mg/dl for men 50--59 years old, 165 mg/dl for men 60--69 years old). Nutrient intake data for mean ages 40--59 years showed 23% of calories from fat for clerical workers in Osaka, the highest among the study groups, whereas farmers in Akita showed a low level of 14%. The ratio of dietary polyunsaturated to saturated fatty acids was over 1.1 for all groups. Cholesterol intake was 339--487 mg/day. Total carbohydrate as a percentage of calories was 53--65%; 75--80% of carbohydrate energy was ingested from cereals. Sugar accounted for less than 3.5% of total calories. In the cross-group correlation analysis between dietary lipid intake and serum total cholesterol, a significant strong positive correlation was found between the dietary lipid factor (phi) of Keys et al. and the mean serum total cholesterol level. A weak but significant correlation was observed between the dietary lipid factor and serum total cholesterol for individual inhabitants of Osaka.

Adult↗
PubMed1980

Multivariate analysis of risk factors for stroke. Eight-year follow-up study of farming villages in Akita, Japan.

Akita Prefecture has an especially high mortality rate from stroke, and its age-adjusted death rate from stroke is the highest in Japan. We have carried out an epidemiological survey of cardio- and cerebrovascular diseases (CVD) in farming villages in this prefecture since 1963, with a response rate of 84%. During our 8-year follow-up, 94 new stroke cases were observed among 1,814 subjects. Multiple logistic function analysis was carried out on nonstroke and stroke cases from subjects aged 40 to 69 years at time of initial examination, in order to clarify the risk factors for stroke. The analysis used eight variables: age, sex, systolic blood pressure, obesity index, urinary sugar, urinary protein, serum total cholesterol, and total protein. The results showed that hypertension was the most important risk factor for stroke. However, regarding cholesterol, multivariate analysis showed that among men and women aged 40 to 69 years at entry, subjects with low serum total cholesterol levels were more prone to cerebral hemorrhage, but that serum cholesterol level had no weight as a risk factor for cerebral infarction. These results correspond well with the observed fact that stroke incidence or death rate in Japan is higher in populations with high prevalence of hypertension and low concentration of cholesterol, and also with the fact that death rate from hemorrhage declines with the increment of serum total cholesterol and the westernization of diet.

Adult↗
PubMed1978

Glucose tolerance in spontaneously hypertensive rats.

In order to clarify the relationship between essential hypertension and glucose metabolism, and to approach the pathophysiology or the etiology of essential hypertension, we examined glucose tolerance test (GTT) using spontaneously hypertensive rats (SHR) as models. SHR, namely stroke-prone SHR (SHRSP) and stroke-resistant SHR (SHRSR) always had higher serum glucose levels at each GTT phase than normotensive control Wistar-Kyoto rats. They also tended to show higher levels in the young even at 5 weeks of age rather than in the adult. These results indicate that hyperglycemic tendency or lower glucose tolerance may be a characteristic of spontaneous hypertension and may be related to the mechanism of hypertension.

Animals↗
PubMed1978

Methods of electrophoretical application of estrogen to a single neuron of the brain under in vivo and in vitro conditions.

The techniques of the electrophoretical study of hormone sensitivities of neurons were examined in vivo and in vitro. For the in vivo study, estrogen and other hormones were applied electrophoretically to neurons of the rat brain of both sexes under urethane anesthesia. Some neurons were sensitive to estrogen and their activities were all inhibited. These neurons were distributed in the hypothalamus and the septal nucleus of the limbic system. So the in vivo method affords direct evidence for the presence of estrogen-sensitive neurons in the brain. Then a useful method was found to study the similar effects under the microscopic observations of a single neuron instead of stereotaxic insertion of the microelectrode. By this in vitro method the chemicals and hormones are able to be applied to any point on a single neuron through the micropipette and the medium composition around the neuron can be variously changed at the same time.

Action Potentials↗
PubMed1976

Epidemiological studies of cerebro-and cardiovascular diseases in the northeast of Japan Part I. Pathological approach to the study in Akita Prefecture.

To define the etiologic factors of Japanese cerebrovascular diseases, a pathological research was conducted on autopsy cases of stroke in Akita Prefecture. In most cases of cerebral hemorrhages, especially in the middle age group (30-59 of age), arteriosclerotic deviations in basal berebral arteries of the circle of Willis and intracerebral small arteries are not found. The authors conclude that cerebral hemorrhage may occur without relationship to disturbances of lipid metabolism, biochemically, and to atherosclerosis, pathologically. Concerning cerebral infarction, especially in the old generation (over 60 years of age), severe arteriosclerotic deviations were recognized both in basal cerebral and intracerebral arteries. These changes were highly influenced by the grade and duration of hypertension, and rarely influenced by hypercholesterolemia. According to the above-mentioned facts, the results obtained from out epidemiological survey were confirmed by the pathological studies.

Adult↗
PubMedDate not supplied

Epidemiology of hypertension in China and Japan.

Hypertension is a major risk factor for cardiovascular disease in Chinese and Japanese with a low to moderate serum cholesterol level. The prevalence of hypertension is diverse in Chinese populations with different geographic region, lifestyles and cultures. The same diversity was observed in Japan in the past, but recently the regional difference has become smaller. The large decline in stroke mortality in Japan was followed by a reduction in the prevalence of hypertension and the lowering level of blood pressure. This is partly explained by various community-based hypertension control programmes. Chinese populations are now showing similar patterns as those observed in Japan. These populations still have high proportions of undetected hypertensives and untreated patients in China. In both Chinese and Japanese, high salt consumption is one of the most important risk factors for hypertension. In addition to this, the increase in body weight, smoking and alcohol consumption in Chinese people seems to be the major factors for the increasing trends in hypertension. Control of hypertension and lowering blood pressure in the population level should be the important strategies for the prevention of cardiovascular disease in Chinese and Japanese.

Blood Pressure↗
PubMedDate not supplied

Effect of dietary sodium reduction on red blood cell sodium concentration and sodium-lithium countertransport.

A randomized, crossover trial was carried out on the effect of moderate sodium reduction on red-blood-cell sodium metabolism. The participants were healthy high school students (mean age = 16 years, n = 33). Changes in sodium-lithium countertransport and intracellular sodium concentration were evaluated 24 days after a decrease in dietary sodium from approximately 110 to 40 mEq per day. Dietary sodium restriction had no significant effect on either sodium-lithium countertransport or intracellular sodium concentration.

Adolescent↗
PubMedDate not supplied

Regional differences in stroke mortality and alcohol consumption in Japan.

The relationship between alcohol consumption and stroke mortality in 1975 in 46 prefectures of Japan was investigated. This was done by adjusting salt intake and several socio-economic factors, i.e., the annual per capita income, the number of persons who received public aid, the number of tatamis (a Japanese traditional floor unit) per household, the unemployment rate, and the unmarried or divorce rate, using a stepwise multiple regression analysis. As dependent variables, the sex-specific and age-adjusted mortality for the middle-aged (35-59 years) and for all ages due to stroke were used. For men, alcohol consumption was significantly related to age-adjusted stroke mortalities for the middle-aged and for all ages independent of salt intake and several socio-economic factors. Alcohol consumption was more strongly related to age-adjusted stroke mortality for the middle-aged than for all ages. For women alcohol was weakly correlated with the stroke mortality of the middle-aged. Salt intake was significantly correlated with stroke mortality for women but not for men. Furthermore, the male: female ratios of the age-adjusted stroke mortality for the middle aged and for all ages were analyzed as well, because alcohol is mostly consumed by men in Japan, and it was expected that the sex ratios would be well correlated to alcohol consumption. The results were as expected. Therefore, it was suggested that the regional difference in stroke mortality in Japan may be explained in part by that of alcohol consumption.

Adult↗