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Biomedical subjects

H Vallés

Publications and source records attributed to H Vallés.

At least 19 recordsLinked to original sources
PubMed2005

[Cochlear implants in Aragón].

Cochlear implants are, actually, one of the major advances in the treatment for profound deafness. His use is, already, a routine in the daily practice of our specialty. Due to its special aspects, cochlear implants have to be done following a protocol that organizes and coordinates the different aspects of the diagnoses and treatment of profound deafness, in the different administrative and geographical fields. The health system in our country and the smale dimension of our area, has taken us to create and follow a special program in which all the available resources are used. Following this protocol, we have performed 63 cochlear implants, in the last 10 years. We show here the results and complications.

Adolescent↗
PubMed2005

[Design and performance of a laboratory of olfactory test. Application of a new evaluation system].

BACKGROUND: To study and evaluate the factors that may influence on human olfactory sensibility to pyridine, we designed a specific laboratory with a new olfactory test to perform accurate measurements. METHODS: We have chosen pyridine as the test substance in our laboratory, for its frequent use of it in other studies. The special conditions of our laboratory are designed to allow individuals to access to this substance, controlling the different factors and parameters. With this purpose, we have validated the test and we have settled the reference threshold values with the score of thirty voluntary healthy patients between 20 and 40 years of age. RESULTS: We have used four different concentrations of pyridine to study the different factors of olfactory sensibility. 95% of cases detected the highest pyridine concentration and the remaining concentrations allowed us to know the olfactory sensibility of the studied population and the inferior thresholds. CONCLUSIONS: We have designed, performed and endorsed a laboratory for the study of olfaction. We have determined the sensibility of the studied population to different concentrations of pyridine that can be considered as a reference for further studies.

Adult↗
PubMed2003

[Laryngeal chondro-radionecrosis].

Laryngeal chondroradionecrosis is a complication following radiotherapy for laryngeal tumours that may appear many years after the treatment. We present the case of a 78 year old man, that come to the Accident and Emergency department with a prelaryngeal mass and hemoptysis. He had been treated 17 years before with radiotherapy for a vocal cond carcinoma. Posteriorly the lesion did a cutaneous fistula with complete laryngeal exposition and torpid evolution. Post-radiotherapy necrosis in the larynx is a serious complication though not a common one. A tumour recurrence needs to be excluded and even in this case a total laryngectomy is mandatory as it will end in total loss of laryngeal function.

Aged↗
PubMed2000

Human E2F5 gene is oncogenic in primary rodent cells and is amplified in human breast tumors.

E2F transcription factors (E2F1 to 6) are central players in the control of animal cell proliferation as regulators of genes involved in cell cycle progression and in transformation. In this report, we have investigated the potential involvement of the E2F5 gene in tumorigenesis. We show that E2F5 can promote the formation of morphologically transformed foci in primary baby rat kidney cells (BRK) when it is overexpressed in the presence of its heterodimeric partner DP1 and activated RAS. This suggests that E2F5 behaves like a MYC-type cooperating oncogene in functional assays, prompting us to monitor potential amplifications of the E2F5 gene in primary human tumors. We mapped the human E2F5 gene to 8q21.1-21.3 equidistant from the MOS (8q12) and MYC (8q24) oncogenes. Since the long arm of chromosome 8 is frequently the site of increased gene copy number (ICN) in breast cancer, we screened 442 breast tumor DNAs for gains of E2F5, MOS, and MYC genes. The three genes showed ICN, albeit at variable incidence and levels of amplification, with the ICN of E2F5 occurring concomitantly with those of MOS and/or MYC in almost half of the cases. Moreover, a marked increase of the 2. 5-kb E2F5 transcript was also detected in some tumors and tumor cell lines. In conclusion, the evidence that sustained unregulated expression of E2F5 can cooperate with other oncogenes to promote cell transformation in functional assays, together with the detection of chromosomal amplifications and overexpressions of the E2F5 gene in breast tumors, provides the first indications that E2F5 deregulation may have a role in human tumor development.

Animals↗
PubMed1998

[Experimental microsurgery of the facial nerve: end-to-end suture versus approximated ends wrapped with masseter muscle aponeurosis].

As an alternative to end-to-end facial nerve microsurgery, we propose anastomosis of the sectioned nerve ends and wrapping with ipsilateral masseter fascia. This intervention was performed on the right facial nerve of 20 Wistar rats and compared with classical end-to-end anatomosis performed on the left nerve of the same rats. At the end of the experiment, histological studies were made of each nerve removed "en bloc" with the ipsilateral lip orbicular muscle. Five micra-thick sections were stained using conventional and immunohistochemical methods. We analyzed truncal integrity, fibroblast proliferation, demyelination, lymphocyte proliferation, granulomatous reaction, and muscle degeneration in both types of anastomosis. The differences between the two types of anastomosis were statistically non-significant, and both interventions produced similar functional results. Small differences between the techniques might condition the use of one or the other in selected cases.

Anastomosis, Surgical↗
PubMed1997

[Perceptive deafness and AIDS].

We report a case of a 23 years old woman HIV positive for the past five years with a four year history of right perceptive hypoacusia evolution without tinitus, vertigo or any other otologic symptomatology. After reviewing her personal and family history and conducting imilar tonal audiometry, tympanometry bilateral, contralateral estapedial reflex, auditory evoked brain stem response and a bilateral nasal fiberendoscopy, we analyzed the evolution of her immunal deficiency and the treatments to which she has been submitted with the purpose of determining the risk factors that have coincided in this case to be able to establish some criteria to follow the auditive affect in HIV positive patients.

Acquired Immunodeficiency Syndrome↗
PubMed1997

[Current status and clinical experience in the treatment of tracheobronchial stenoses with self-expanding metallic stents].

The development of symptomatic stenosis in the bronchial tree can lead to high risk asphyxia. The implantation of metallic prostheses (stents) can provide palliative resolution of stenosis and alleviate the acute symptoms of these patients. We assess the efficacy of expandable metallic stents for treating various types of tracheobronchial stenosis. Sixteen Wallstent type expandable metallic prostheses were implanted in 16 patients with tracheobronchial stenosis (12 malignant and 4 benign) in the interventional radiology unit under fluoroscopic and endoscopic guidance. The prostheses were placed correctly and no complications were observed, such that symptoms improved immediately. Three patients with post-intubation stenosis required additional treatment with laser therapy during follow-up examinations. All the patients with malignancies died from the underlying disease, but with open airways and no tracheal symptoms. Metallic prostheses are a valid alternative for palliative treatment of malignant tracheobronchial stenosis.

Adult↗
PubMed1997

[Sinus manifestations of the acquired immunodeficiency syndrome].

OBJECTIVE: We decided to review the different disorders which may affect the paranasal sinuses in the course of the acquired immuno-deficiency syndrome, and the most suitable treatment for them. DEVELOPMENT: Involvement of the paranasal sinuses is not particularly common in the acquired immuno-deficiency syndrome. The commonest disorder is sinusitis. Also seen are lymphomas no-Hodgkin, small cell, Burkitt's or no Burkitt and immunoblastic. Cases of Kaposi's sarcoma or malignant tumors such as a schwannoma may appear. In our hospital, an HIV+ patient presented with a frontal cerebral abscess which had developed from sinusitis of the whole left paranasal sphere. We have therefore reviewed 150 histories of HIV+ patients and the relevant literature available. CONCLUSIONS: Only in 3.3% of the HIV+ patients reviewed did sinusitis develop during the course of their illness. In one of these, there was intracranial spread of infection with the appearance of cerebral abscess following infection by Streptococcus milleri. We emphasize the review of the literature dealing with sinus pathology in these patients. On many occasions diagnosis was not made since it was masked by other infections. Cure is difficult and relapses are frequent in spite of suitable treatment and are associated with decline in immunocompetence.

Acquired Immunodeficiency Syndrome↗
PubMed1994

Unusual association of secondary tonsillar and cerebral tuberculosis.

The patient was a 50-year-old alcoholic man with a left palatine tonsillar ulcer. Histopathological and bacteriological studies established the diagnosis of tonsillar tuberculosis with asymptomatic advanced pulmonary tuberculosis and multiple cerebral supra- and infratentorial tuberculomas previously unnoticed.

Alcoholism↗
PubMed1993

[Usher syndrome. Two case reports].

Usher's syndrome is an autosomal, recessively inherited trait that combines a congenital hearing impairment with retinitis pigmentosa. The AA. present the cases of two brothers affected. The actual classification and the last etiopathogenic theories are revised.

Adolescent↗
PubMed1992

[Initial otorhinolaryngologic lesions of lepromatous leprosy].

The paper deals with a topic rarely treated in the bibliography: a carrier of cutaneous and otolaryngologic lesions suspicious of lepromatous leprosy. The AA. made a survey of the typical ENT manifestations of the generalized disease--lepromatous leprosy--and recall the more characteristic diagnostic tests as well as the guide lines of the treatment.

Adult↗
PubMed1990

[Ethmoid-maxillary mucocele as a manifestation of primary lymphoma of the orbit].

A primary lymphoma of the orbit developed at par with a mucocele of the sinus (perhaps originated by the tumor) made very difficult the diagnosis of the patient. About this case the AA, consider the aspects more interesting of the primary lymphoma of the orbit and the possible influence of this kind of tumors as starting point of the mucocele.

Adult↗
PubMedDate not supplied

[Evaluation with acoustic rhinometry of surgical results in patients undergoing septoplasty].

We used acoustic rhinometry to evaluate the surgical results of septoplasty in patients with nasal respiratory insufficiency caused by morphological abnormalities of the nasal septum. Acoustic rhinometry is a relatively new exploration method for the nasal cavity that yields objective spatial measurements. These measurements are the cross sections and volumes of the nasal cavity divided longitudinally into two regions, an anterior region up to 32 mm from the nasal orifices and the posterior region, up to 64 mm from the same point. We studied 45 patients with nasal respiratory insufficiency who had undergone septoplasty. Measurements were made before and after surgery. Our results show a clear increase in nasal sections and volumes after surgery. They confirm the benefits of acoustic rhinometry as a method for quantifying morphological abnormalities of the nasal cavity.

Acoustics↗
PubMedDate not supplied

[A case of lingual ischemia].

We are presenting a case of the ischemic necrosis of the two front thirds of the left hemi-tongue, which as appear in a elderly patient, with a generalised arteriosclerotic vasculopathy. We emphasize the fact that it manifested itself, little by little, characteristic which is qualified as no typical example and in the context of a important toxic syndrome. We've undertaken moreover a bibliographic review of the matter.

Aged↗
PubMedDate not supplied

[Palliative treatment of malignant neoplasms of the upper aerodigestive tract].

We present a syntheses of the most important local and regional palliative measures in the treatment of the malignant tumors of the upper respiratory and digestive tract. We have considered the palliative therapeutic directed to the tumor itself, the maintenance of the air-flow and the nutrition, the treatment of the pain, of the hemorrhage, of the infection and of the alterations of the loco and regional trophism. In relation to palliative treatment directed at the tumor itself, we have analyzed the role of the chirurgie, the physiotherapy and chemotherapy.

Diet↗
PubMedDate not supplied

[Irreversible bilateral amaurosis secondary to the course of ethmofrontal mucocele].

We present a carrier of a mucocele ethmofrontal patient's case that relapsed after surgical treatments and that, subsequently, it caused an intense bilateral and amaurosis. This was attributed to the bilateral atrophy of the optician nerve secondary to the evolution of the own mucocele. It discussed the frequency of this kind of complications in the bibliographical revision made.

Aged↗