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H Vargas

Publications and source records attributed to H Vargas.

At least 73 records · Page 4Linked to original sources
PubMed1986

Pharmacokinetics of gentamicin in children with nephrotic syndrome.

The disposition of gentamicin was studied in five children with nephrotic syndrome and five control children to observe the effect of nephrotic syndrome on the distribution and elimination of the antibiotic. After a single intravenous dose of gentamicin (2.0 mg/kg body wt.) administered to each child, blood samples were drawn at frequent intervals during a 4-h period and then analyzed by homogeneous enzyme immunoassay (EMIT). Time-concentrations drug profiles were characterized by means of a two-compartment open model. The mean half-life of gentamicin in nephrotic children (96.4 +/- 16.8 min) was significantly longer than in the control group (62.5 +/- 7.1 min). The distribution volume of the central compartment was similar in both groups studied, but the distribution volume at steady-state was increased in children with nephrotic syndrome. Total plasma clearance was found decreased in nephrotic (2.8 +/- 0.5 ml/min/kg) in comparison with controls (3.7 +/- 0.7 ml/min/kg). From our findings, it could be concluded that serum level of children with nephrotic syndrome treated with gentamicin should be carefully monitored in order to avoid the toxic effects of the antibiotic.

Child↗
PubMed1983

[Continuous intra-arterial perfusion of prostaglandin E1 in inoperable stage-IV arteriopathies].

Inoperable stage IV arteriopathies have been treated by intra-arterial PGE1 infusion since January 1978. Inoperability was established in all cases by angiography or by attempted exploration and angiography during operation. Strict criteria for therapy were applied with the result that treatment was administered to only 100 patients among 3,335 cases undergoing vascular surgery. Dosage was 0.1 to 0.2 ng of PGE1 per kilo of body weight and per minute, mean duration of treatment being 34 days. Of the 100 limb extremities probably requiring wide amputations, 47 were saved from immediate amputation, the majority of patients in whom amputation could not be avoided being diabetic. Follow-up in July 1982, 1 to 4 years after treatment, showed that 24 extremities were still intact. Best results were noted in patients with endangiitis obliterans, and long-term results no longer demonstrated differences in patients with or without diabetic arteriopathy. Intra-arterial therapy can be repeated if necessary.

Acute Disease↗