Biomedical subjects

H Vaverková

Publications and source records attributed to H Vaverková.

At least 37 records · Page 2Linked to original sources

PubMed1993

[Lipoprotein (a): a genetic risk factor for early ischemic cerebrovascular stroke].

In 45 subjects after a cerebrovascular attack (age less than 55 years) and their first degree relatives -45 siblings, 60 children, 9 parents and 31 partners--lipoprotein (a) levels by the ELISA method as well as some other lipids, lipoproteins and apoproteins were assessed and compared with two control groups (I and II) of healthy subjects with a negative family history of early atherosclerosis. The lipoprotein (a) levels were significantly higher not only in probands, as compared with the control group I (27.4 +/- 30.7 x 16.0 +/- 18.9; p < 0.05, Mann Whitney U-test) but also in their children when compared with control group II (28.1 +/- 31.9 x 12.5 +/- 16.3; p < 0.05). The lipoprotein (a) levels did not correlate with age, there was, however, a significant positive correlation with total cholesterol (r = 0.2244, p < 0.01), LDL-cholesterol (r = 0.2834, p < 0.0001) and apolipoprotein B (r = 0.1759, p < 0.05) when Spearman's correlation coefficient was used. Familial dyslipidaemia Lp (a) defined as lipoprotein (a) higher than 25 mg/dl (or 30 mg/dl resp.) at least in two close relatives in one family was found in 27% (and 21.6%) evaluated families (10/37 and 8/37 resp.). "Risk" levels of lipoprotein (a) > 25-30 mg/dl were found most frequently in combination with other types of hyperlipoproteinaemia--in subjects with types IIa and IIb, in families in combination with familial combined hyperlipidaemia. The results indicate that "risk" levels of lipoprotein (a) are a frequent genetically conditioned metabolic disorder in patients with premature ischaemic cerebrovascular attacks.

Adult↗

PubMed1992

The preheparin and postheparin lipids of high density lipoprotein subfractions: relation to the serum insulin and postheparin plasma lipase activities in normal human.

The preheparin and postheparin lipoprotein lipids (cholesterol C and triacylglycerols TAG) were related to the serum insulin and to the postheparin plasma activities of lipoprotein lipase (LPL) and hepatic lipase (HL) in normolipemic human. The positive correlation, although not statistically significant, of insulin level of the LPL activity was found, while no correlation to the HL activity was seen. Under preheparin conditions: 1) both insulin level and LPL activity were negatively related to the VLDL-C/TAG ratio indicating an enrichment of VLDL with TAG, 2) moreover, the LPL activity was positively related to the HDL-C and HDL3-C, 3) the HL activity predominated in relation to the HDL, and particularly to the HDL3, as indicated by negative correlations to the both lipids and to the lipid/apoA-I ratios of HDL and HDL3. This lipid depletion of HDL3 was more expressive due to the TAG, while HDL2 appeared to be relatively enriched with TAG, as suggested by correlations of C/TAG ratios with HL activity. The in vivo acceleration of lipoprotein metabolism by heparin resulted in: 1) the reduction of VLDL-TAG and HDL2-TAG, and in the increase of HDL3-TAG, 2) the appearance of positive relation of HDL2-C to the LPL activity and of opposite relation to the HL activity, 3) the lack of HL correlation to the TAG of HDL and HDL3. Even under these conditions no relation of insulin level to any HDL lipid was revealed. The results suggest that in normal human the HL affects more considerably than LPL the lipid metabolism of HDL subfractions and it does not seem to be under insulin control.

Adult↗

PubMed1991

[Personal experience with lovastatin, a HMG-CoA reductase inhibitor (Mevacor, MSD) in the treatment of hypercholesterolemia].

The authors administered lovastatin (Mevacor, MSD) to 18 patients with primary hyperlipoproteinaemia (familial and non-familial) with a lipoprotein pattern type IIa and IIb. During treatment a marked reduction of atherogenic indicators of the lipid metabolism occurred, i.e. a decline of total cholesterol (-28.6%), LDL-cholesterol -39%), apolipoprotein B (-18.6%), the index of total cholesterol/HDL-cholesterol (-44.6%) and the index LDL-cholesterol/HDL-cholesterol (-48.2%). At the same time a favourable effect on indicators of the lipid metabolism to which a protective action is ascribed was recorded: a rise of HDL-cholesterol (+13.6%) and apolipoprotein AI (+13%) and AII (+13%). An excellent effect was observed also in four heterozygotes with familial hypercholesterolaemia which is usually rather resistant to other types of hypolipidaemic treatment. The drug was very well tolerated and subjective side-effects of treatment were minimal. Despite the fact that a number of laboratory indicators was followed up, the authors did not observe any undesirable side-effects, only a transient and marginal rise of ALT in one patient. Lovastatin is, due to its potent hypolipidaemic effect, a new hope in the treatment of hypercholesterolaemia. Its usefulness in the prevention of ischaemic heart disease, as well as its safety during prolonged administration are tested at present in long-term investigations.

Female↗

PubMed1990

Effect of manganese ions on HDL2 precipitation with dextran sulfate.

The dual precipitation method involving the separation of HDL and HDL3 from normolipemic serum by heparin-MnCl2/dextran sulfate was evaluated with regard to the Mn2+ effect on HDL2 precipitation with dextran sulfate (DS) in the second precipitation step. Increased HDL2-C and HDL2-TAG values brought about by increased Mn2+ concentrations were found at all DS concentrations studied. The comparison of the lipid HDL2 and HDL3 values with those given by polyethylene glycol precipitation method yielded two optimal combinations of DS/Mn2+ concentrations: 1.11 g.l-1/0.076 mol.l-1 and 0.87 g.l-1/0.091 mol.l-1. The obtained results call attention to the importance of final concentration of Mn2+ ions at HDL2 precipitation with DS from heparin-Mn2+ supernate containing HDL.

Adult↗

PubMed1990

[Obliterative disease of the carotid and peripheral arteries in hyperlipoproteinemia].

The authors give an account of changes of the carotid and peripheral arteries detected by ultrasonic examination in a group of 133 patients with different forms of primary hyperlipoproteinaemias. Stenoses in the extracranial carotid circulation were found in 31% of the group, stenoses of the peripheral arteries in 37%; in 18% combined changes of the carotid and peripheral system were found. The authors proved a rising trend of the number of risk factors with the rising number of arterial stenoses. The most frequent risk factors were obesity and smoking. In the entire group changes of the peripheral arterial system were found in more than half the patients (in 53%); in clinically asymptomatic subjects they were proved in 39%. The authors emphasize the necessity to introduce ultrasonic screening of the arterial system in all patients with hyperlipoproteinaemia.

Arteriosclerosis↗

PubMed1989