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Biomedical subjects

H Viard

Publications and source records attributed to H Viard.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Transplantation of human cryopreserved adenomatous and hyperplastic parathyroid tissue to the hypocalcemic nude mouse.

Cryopreserved parathyroid glands from patients operated on for hyperparathyroidism were stored for further auto- or allografting. In an attempt to better use cryopreserved parathyroid glands in humans, we designed a study whose goal was to compare human parathormone (hPTH) secretion from cryopreserved parathyroid glands with regard to tissue histology (adenoma or hyperplasia), mass, and time of storage in hypocalcemic Nude mice and to be able to better use them in humans. A new hypocalcemic experimental model, using parathyroidectomized Nude mice was set up. Hypocalcemic mice received calibrated grafts from human parathyroid glands cryopreserved between 1982 and 1992 originating from 30 patients (15 adenomas, 15 hyperplasias). Each parathyroid was grafted into two mice under the ratio of one mass-unit (12 mg) and three mass-units (36 mg). The hPTH concentration was assessed by an immunoradiometric method 21 days after grafting. The mean cryopreservation time was 677 days (54-3187 days). The time of cryopreservation was identical in the two kinds of tissue (p = 0.88). The hPTH concentration in 59 living mice was 72.2 +/- 271.4 (SD) ng/ml (3-1936 ng/ml). This concentration was 7.1 +/- 4.3 ng/L for adenomas versus 139.4 +/- 378.6 ng/L for hyperplasias (p = 0.003) and 87.1 +/- 352.6 ng/L for one-unit-mass grafts versus 56.7 +/- 152.5 ng/L for three unit-mass grafts (p = 0.824). Hyperplastic glands showed more secretion, which was confirmed in both mass related groups (p = 0.02, p = 0.006).(ABSTRACT TRUNCATED AT 250 WORDS)

Adenoma↗
PubMedDate not supplied

[Risk factors in aorto-iliac surgery (author's transl)].

The authors report a statistical analysis of 163 operations of aorto-iliac vascular surgery. A detailed study of their 14 deaths showed the various causes of mortality (immediate post-operative thrombosis, acute renal failure, digestive complications, septic cardiac, pulmonary, hemorrhagic and cerebro-vascular accidents). This analysis, compared with the findings in all the operated patients showed the main factors of risk in this type of surgery (age over 70 years immediate and late reoperations, heart lesions, renal, pulmonary and late lesions, the risk of sepsis). The indicate the means of prevention of such accidents and the therapeutic attitude when they occur. They conclude that the contra-indications are relative, but should be observed in order to lower the risk of this surgery below 5 p. cent mortality rate.

Age Factors↗
PubMedDate not supplied

[Ulcers of the neck of hiatal hernias. 15 cases].

Of 450 patients treated for hiatus hernia, a review of case-reports showed ulcers of the neck in 15 patients (3,1%). Frequency of hemorrhage was high (13/15), and it was sometimes severe, one patient dying from massive bleeding preoperatively. Diagnosis was by radiology in 11 cases, by endoscopy in 3 and perioperatively in one case. Data on physiopathogenicity include both mechanical and chemical factors. Conservative treatment with repair of hiatus hernia combined or not with vagotomy was performed in 11 patients. Severity of hemorrhagic phenomena or absence of preoperative biopsy led to direct surgery on ulcer in 3 cases, while evidence of mediastinal inflammatory processes required major surgery in 1 patient and an upper pole esophagogastrectomy in another. Long-term follow up failed to show evidence of recurrence of ulcer or hemorrhage.

Aged↗