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Biomedical subjects

H Villarreal

Publications and source records attributed to H Villarreal.

At least 19 recordsLinked to original sources
PubMed1983

Effects of the acute and chronic administration of indapamide on systemic and renal haemodynamics in essential hypertension.

The effects of acute and chronic administration of indapamide on systemic and renal haemodynamics were studied in 10 patients with arterial essential hypertension. No important changes were observed on mean arterial blood pressure, cardiac index and total peripheral resistance during acute administration of the drug. Chronic administration produced a significant reduction in both mean arterial blood pressure and total peripheral resistance whereas the cardiac index did not change. Glomerular filtration rate diminished significantly during the acute administration of the drug, while renal plasma flow remained unchanged. Urinary volume did not change whereas osmotic clearance increased and free water clearance decreased evidently. Both urinary sodium and potassium increased significantly during acute administration of indapamide. Long-term administration of this substance had no effect on renal haemodynamics.

Adult↗
PubMed1979

The occurrence of a protein in the extracellular products of streptococci isolated from patients with acute glomerulonephritis.

The present report compares the extracellular proteins of streptococci by sodium dodecyl sulfate polyacrylamide electrophoresis. A marked variation in the streptococcal extracellualr proteins (SEP) of different strains was detected, even in strains of similar serotypes. It was possible, however, to identify a single protein band that occurred predominantly in the SEP of strains isolated from patients with acute poststreptococcal glomerulonephritis (APSGN). This protein was generally not produced by streptococci obtained from patients without this disease. It appears to be immunologically similar in the various serotypes of streptococci isolated from patients with APSGN and can be demonstrated by immunofluorescence techniques to be present in the glomeruli of these patients.

Antigens, Bacterial↗
PubMed1977

Effect of guancydine on systemic and renal hemodynamics in arterial hypertension.

The effect of guancydine (1-cyano-3-tert-amylguanidine) on systemic and renal hemodynamics was studied in nine patients with arterial hypertension. Antihypertensive drugs were withheld for 15 days before beginning the investigation. Average sodium intake was 105 meq/24 hours in some patients and 25 meq/24 hours in others. Patients received placebo during a control period that averaged 14 days. Guancydine was given for 7 to 18 days at an average dose of 21 mg/kg of body weight. Although mean arterial blood pressure decreased significantly in all patients, it reached normal levels in only two. There was no change in cardiac output. Glomerular filtration rate and renal plasma flow remained unchanged, whereas urinary sodium excretion diminished, suggesting an activation of the renin-angiotensin-aldosterone system. A substantial gain in body weight was noted. Nausea, vomiting, constipation, somnolence, restlessness, mental confusion, asthenia, and urine retention were observed. The anti-angiotensin effect of guancydine that has been described in animals was not observed.

Blood Pressure↗
PubMed1975

[Phagocytosis in patients with splenectomy].

Phagocytosis was evaluated in nine patients with splenctomy undergoing renal transplant, eight renal transplanted patients without splenectomy, three immunodepressed patients with terminal renal failure, four patients with splenectomy and six healthy volunteers. For phagocytosis evaluation, neutrophils adhered to glass were used. They were cover with 4% latex and albumin containing culture medium with or without phagocytosis stimulating tetrapeptide extracted from IgG in each case. Phagocytosis was decreased in all groups studied. Immunodepressed patients showed the highest diminishment of phagocytosis and patients with splenectomy and immunodepression the lesser. It was speculated that such a finding is due to a decrease of tetrapeptide in serum.

Acute Kidney Injury↗
PubMedDate not supplied

[Use of cyclophosphamide in membranoproliferative glomerulonephritis].

A study was made of the effect of ciclofosfamide on the nephrotic syndrome, glomecular filtration rate, immuproteins clearance complement, and urinary sediment in 14 patients with membranoproliferative glomerulonephritis. It was found that the nephrotic syndrome disappeared in 7 out of 8 cases, the glomerular filtration rate increased significantly in 13 out of 14 patients, and there was no correlation between the action of the drug and the behavior of the immunoglobulins clearances, complement, and the urinary sediment. Neither was there found a correlation between the increased renal function and the histological spectrum.

Adolescent↗
PubMedDate not supplied

[Malignant hypertension. Report of a case].

A case of malignant arterial hypertension, treated with sodium nitroferrecianuro, beta blockers, vasodialators, and hemodialysis with hyposodic baths is presented. It shows the favorable response to this type of treatment, in the cardiac sphere as well as the alteration in the eye grounds. The etiopathogenisis and treatment of malignant arterial hypertension, and indications for the nephrectomy and renal transplant are discussed.

Adult↗