PubMed Health⌕ Search

Biomedical subjects

H Vogelsang

Publications and source records attributed to H Vogelsang.

At least 19 recordsLinked to original sources
PubMed1992

[Results of allogenic and autologous bone marrow transplantation in children with acute myeloid leukemia].

We report on our experience of bone marrow transplantation (BMT) in children with acute myeloblastic leukaemia (AML) and high risk of relapse (initial WBC greater than 20 x 10(9)/l, FAB M 5, M 6, M 7). 32 children were grafted between november 1982 and october 1991 at the Children's Hospital of the University of Jena. Two patients underwent an allogenous BMT in relapse and died from progressive disease. In 13 children an allogeneic BMT was performed in first complete remission. One patient relapsed, two patients died from severe acute graft-versus-host disease, and two patients died from encephalopathy and cardiomyopathy. Eight of the 13 patients are living and well 18 months to eight and a half year after BMT. Seventeen patients received an autologous (unpurged) BMT. Four of them relapsed four to seven months after BMT. The disease free survival (DFS) for the 29 patients grafted in remission was 0.65. There was no statistical significant difference in DFS between patients with allogeneic and autologous BMT. We conclude that in children with AML and high risk for relapse BMT offers a real chance for better survival. Autologous BMT avoids the problems of graft-versus-host disease and of finding suitable donors for allogeneic marrow transplantation.

Adolescent↗
PubMed1991

Comparison of enteral nutrition and drug treatment in active Crohn's disease. Results of the European Cooperative Crohn's Disease Study. IV.

This study compared the effect of enteral nutrition as the sole therapy of active Crohn's disease with drug treatment. Patients with active Crohn's disease (Crohn's Disease Activity Index greater than 200) were randomized to receive either enteral nutrition with a liquid oligopeptide diet (n = 55) or a combination of 6-methylprednisolone, 48 mg daily, subsequently tapered, and sulfasalazine, 3 g daily (n = 52). The two groups were not different with respect to age, sex, body weight, location of disease, or treatment before the study. The severity of disease was similar at the beginning of the study in both groups [Crohn's Disease Activity Index (mean +/- SEM), 323 +/- 12 vs. 316 +/- 11]. Remission was defined as a decrease of the initial Crohn's Disease Activity Index by 40% or at least 100 points. Twenty-nine patients in the diet group and 41 patients in the drug group reached remission within 6 weeks of therapy (chi 2 test, P less than 0.01). The median elapsed time to remission was 30.7 days in the diet group compared with 8.2 days in the drug group (Mantel Cox, P less than 0.01). To determine whether one of these treatments was more beneficial for a subgroup of patients, the effectiveness of both treatments was analyzed separately in patients with very severe disease (initial Crohn's Disease Activity Index greater than 300) and less severe disease (initial Crohn's Disease Activity Index less than 300), and in patients with different disease location. However, no influence of initial disease activity or disease location on the effect of either treatment could be shown. These data show that enteral nutrition is less effective than a combination of 6-methylprednisolone and sulfasalazine in treating active Crohn's disease.

Adult↗
PubMed1979

[Spinal irritation after myelography with Amipaque in patients with kyphoscoliosis (author's transl)].

Two patients with severe kyphoscoliosis developed marked spinal irritation following myelography with the new non-ionising contrast medium Amipaque. The authors raise the possibility that the spinal deformity may result in reduced flow of cerebro-spinal fluid; this may prolong the contact of the contrast medium with the (previously damaged?) spinal cord. Patients with this type of spinal deformity require particularly stringent indications for the performance of myelography, even when using Amipaque.

Aged↗
PubMed1978

The effect of position of patient on the passage of metrizamide (Amipaque), meglumine locarmate (Dimer X) and ioserinate (Myelografin) into the blood after lumbar myelography.

Lumbar myelography was carried out with the contrast media Amipaque, Dimer X and Myelografin in 10 patients each. Five of the patients treated with each contrast medium were kept in a sitting position after the examination, the others lay flat. Blood levels and excretion were measured up to 24 h. The results are interpreted as follows: 1. After lumbar injection of the contrast media there is a short phase of distribution in the subarachnoid space (lag time) and they then are transferred into the blood with a half-life of 3.9 +/- 2.4 h. The transport from the CSF is almost completed approximately after 24 h. The velocity of transport varies greatly between the individual patients. Watersoluble contrast media presumably flow passively with the CSF through the arachnoid villi into the venous blood. 2. The horizontal position of the patient reduces the lag time until the beginning of the actual transfer of the contrast medium. 3. The transfer of Dimer X begins somewhat later compared with Amipaque and Myelografin.

Contrast Media↗
PubMed1978

[Myelography with metrizamide in children (author's transl)].

The non-ionic water-soluble contrast medium metrizamide (Amipaque) allows the examination of all regions of the spinal canal. Excellent visualization, the low toxicity for nervous tissue, and small side effects make metrizamide the best contrast medium for myelography, even in infants and children. The technique used is described and results are demonstrated.

Adolescent↗
PubMed1978

[Fibrous dysplasia of the skull--a radiological, computer tomographic and scintigraphic study (author's transl)].

The diagnosis of fibrous dysplasia (Jaffé-Lichtenstein) of the skull can generally be made by plain films, occasionally supplemented by tomography. The differential diagnosis from sclerosing meningiomas in the anterior fossa can usually be made by cranial computer tomography. Cerebral scintigraphy does not play an important part in the differentiation from a meningioma. Total body scintigraphy, on the other hand, is useful, particularly in distinguishing between monostotic and polyostotic bone conditions. Invasive neurological methods, such as cerebral angiography, are in our opinion unnecessary unless there are definite clinical focal cerebral symptoms in the presence of a normal computer tomogram.

Diagnosis, Differential↗
PubMed1978

[Thoracic myelography with water-soluble contrast medium (metrizamide) (author's transl)].

The use of water-soluble contrast media for the thoracic myelography has become possible with the introduction of Metrizamide (Amipaque). A modification of the technique used with oily contrast media results in excellent demonstration of detail of intraspinal structures and of pathological changes. The medium is well tolerated and does not cause irritation of the spinal cord; the results must be regarded as excellent.

Headache↗
PubMed1978

[Cerebral and spinal angiography with metrizamide (amipaque) (author's transl)].

Metrizamide (Amipaque) has been used as the contrast medium for angiography in neuroradiological investigations. Solutions containing 280 mgI/ml. are well tolerated and produce good contrast. The most important difference from previously used contrast media is the lack of pain when injections are made selectively or super-selectively into the external carotid artery and its branches, or into the spinal arteries.

Adolescent↗
PubMed1978

[Xeroradiography for cervical myelography using metrizamide (amipaque) (author's transl)].

Xeroradiography, particularly in addition to conventional tomography, for cervical myelography using water-soluble Metrizamide has been tested. Xerography was done in 30 of a total of 96 examinations and could be compared with conventional X rays. In the sagittal plane there was no advantage, in the lateral plane detail was clearer, especially at the cervico-dorsal junction and in establishing the extent of osteochondrotic changes narrowing the subarachnoid space. Xeroradiography should not be used routinely, but has its merits for certain problems, when higher radiation will be justified.

Humans↗
PubMed1976

Neuroradiological diagnosis of intraspinal tumors in children.

In the diagnosis of spinal and intraspinal space-occupying processes great importance attaches to radiologic plain film diagnosis, including special projections and tomography. Using refined evaluation methods, direct and indirect signs of tumors can be demonstrated in 30-50% of cases. Of decisive importance is the myelographic examination. It permits the determination of the exact localization and the size of a tumor. Contrast studies frequently allow an identification of the tumor type. Spinal arteriography and phlebography, on the other hand, are of secondary importance in the diagnosis of tumors of both spinal canal and spinal cord. In patients with bone infiltration they accomplish a valuable contribution to determine whether this expansion is directed towards the epidural space or the soft tissue structures of the back.

Adolescent↗
PubMed1976

[Cervical myelography with water-soluble contrast medium (Metrizamide). Technique and preliminary results (author's transl)].

Use of a water-soluble contrast medium for cervical spinal diagnosis has become possible with the introduction of Metrizamide (Amipaqque). Injection of contrast at the C.1/2 level by a lateral approach results in excellent visualisation of the cervical theca with previously unobtainable detail. This technique, which is so far not well known, allows a rapid examination and when used with the new, well tolerated contrast media provides optimal diagnostic results.

Cervical Vertebrae↗