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Biomedical subjects

H Voigt

Publications and source records attributed to H Voigt.

At least 37 records · Page 2Linked to original sources
PubMed1991

[The effect of oral trapidil therapy on clinical and hemorheological parameters in arteriosclerosis obliterans in comparison to pentoxifylline--a pilot study].

20 male patients from 44 to 61 years of age with arteriosclerotic disturbances of the blood supply of the legs (stage II after Fontaine) were in the cross-over treated with 3 x 200 mg trapidil or 3 x 200 mg pentoxifylline daily. The duration of the therapy was in each case 6 weeks with a one-week elutriation phase. Statistically ascertained was an increase of the distance of intermittent claudication for the two drugs in patients with initial values lower than 550 m. On the other hand the tibio-brachial Doppler quotient and the submaximal blood supply established by the venous-occlusion plethysmography did not change. The post-ischaemic recovery phase of the transcutaneous oxygen partial pressure at the lower leg shortened in particular under the influence of trapidil. Lipid parameter, haematocrit, fibrinogen and plasma viscosity remained unchanged. The subjective tolerance of the two remedies was good.

Adult↗
PubMed1990

[Oral trapidil treatment of Fontaine stage II arteriosclerotic circulatory disorders of the legs--a double-blind study].

In a double blind study altogether 41 patients with obliterating arteriosclerosis at stage II after Fontaine have been treated for 26 weeks either with 3 X 100 mg Trapidil (Rocornal) daily or placebo. In the second half of the study under Trapidil in contrast to placebo a clinically relevant additional increase of the distance of the intermitent claudication was the result. On the other hand, the plethysmographically measured reserve of the arterial blood supply did not show any changes in the two groups. A specific influence of Trapidil on the lipoprotein metabolism is apparently not present, since there appeared favourable influence on the hyperlipoproteinaemia diagnosed in 37 out of 41 patients both under placebo and under Trapidil.

Aged↗
PubMed1990

[Possibilities and limits of pharmacotherapy of chronic venous insufficiency].

The conservative therapy of the chronic venous insufficiency is always carried out with etiopathogenetic orientation and according to the stages of disease. Of the medicamentous therapy oedema-protective and vein-tonicising drugs, oral anticoagulants and non-steroidal antiphlogistics are discussed. Furthermore, the alternative and supplementary prescription of physiotherapy and movement cure depending on findings is dealt with.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1990

[Expert assessment of chronic venous insufficiency].

In the expertise of a chronic venous insufficiency kind and stage of the venous disease must be proved as objectively as possible. The diagnostic demands in the individual step programmes serve for the exact assessment of the remaining part of efficiency. The criteria of valuation are summarized, in which case we also deal with several possibilities of combination with other vascular diseases. The expert opinion of an accident is discussed. References to the inability to work, rating of nursing money, increased material benefit in impairments of health and to the acknowledgement of an identity card for injured persons supplement the statements.

Disability Evaluation↗
PubMed1990

[Differential diagnosis of non-thrombotic insufficiency of the conductive veins].

The differential diagnosis of the non-thrombotic insufficiency of conducting veins is in general possible by anamnesis and clinical angiological examination, even if non-vascular diseases are taken into consideration. In other patients, particularly in isolated insufficiency of the conducting veins, in addition to this non-invasive and, if the occasion arises, invasive angiological methods must be used.

Diagnosis, Differential↗
PubMed1990

[Hutchinson-Horton ulcero-necrotizing cranial arteritis].

Arteritis cranialis ulcero-necroticans Hutchinson-Horton is the necrotizing variant of giant-cell temporal arteritis, which was first described by Hutchinson in 1890 and Horton in 1932. Although the histomorphological findings (occluding proliferation of the intima, destruction of the elastica interna, giant-cell infiltration) suggest reactive pathomechanisms, the aetiology of the disease remains rather uncertain. The hypothesis currently favoured is that auto-immunological processes originate from vascular alterations and subsequently lead to the recognition of antigenic determinants by the host immune system being followed by immunological response mechanisms clinically manifest as vasculitis. Arteritis cranialis is most frequently found in the temporal artery; however, the reasons for this preferential location are not clearly established, and giant-cell arteritis can also be found elsewhere. Ulceration of the skin can be encountered and may affect large areas of the scalp, depending on the vascular perfusion pattern involved. The case report described in this paper comprises anamnestic data, clinical and serological findings, and the histological picture typical for giant-cell arteritis. Stress is laid on the importance of early diagnosis to prevent irreversible complications with possibly fatal outcome.

Aged↗
PubMed1990

[Effect of smoking on hemostasis and hemorheology in pregnancy].

We found in normal and pathologic pregnant women who were discordant for smoking impaired haemostaseological and haemorheological parameters. Cigarette smoking provokes an increase of thrombocytes, a hyperfibrinolysis, a haemoconcentration and a decreased deformability of erythrocytes.

Blood Coagulation Tests↗
PubMed1989

[The clinical significance of serotonin antagonists].

Issuing from the physiological role of the serotonine, the possible significance of this biogenic amine for the pathogenesis of cardiovascular diseases is discussed. From this are derived indications for the use of serotonine antagonists. At present, of these ketanserine is regarded as the best investigated substance. The results of the hitherto performed clinical studies justify the application in hypertension. In contrast to this the assessment of the clinical and therapeutic value in chronic arteriosclerotic occlusive disease at stage II according to Fontaine and in Raynaud's syndrome is rendered difficult.

Arteriosclerosis Obliterans↗
PubMed1989

[Lipid metabolism and peripheral hemodynamics in arteriosclerosis obliterans treated with nifedipine--a comparison with pentoxifylline].

In the present study altogether 51 patients with obliterating arteriosclerosis stage II according to Fontaine were examined concerning the haemodynamic and lipid parameters under influence of nifedipine and pentoxifylline, respectively. An antiatherogenic effect under nifedipine takes place possibly by the diminution of the triglycerides in the serum and the blood pressure as well as by the increase of the linolenic acid in the serum (precursor of the vasoprotective prostacyclin I3). Pentoxifylline essentially behaves lipid-neutral. The increase of the intermittent claudication distance clearly speaks for pentoxifylline. - Nifedipine should only be used in concomitant indications.

Arteriosclerosis Obliterans↗
PubMed1989

[The importance of the trace element selenium in internal diseases].

Issuing from the existence of selenium and its interactions with other elements its essentiality in biochemical processes of man was explained. In correspondence with other research teams also own results speak for a relative selenium deficiency in the Middle-European region. Alterations of the cell integrity caused by selenium deficiency may play a role in the etiopathogenesis and perpetuation of chronic cardiovascular diseases as well as of disturbances of the immunoregulation. Recent epidemiological studies and clinical experimental investigations show potential tendencies for prophylaxis and therapy of diseases which are remarkable in health policy.

Cardiovascular Diseases↗
PubMed1989

[Systemically administered regional tumor therapy. Regional hemi-body chemotherapy of metastatic malignant melanoma--an experimental therapy concept].

Since systemic application of a high-dose chemotherapy is limited by the extent of intolerable toxicity and overall response rates so far are rather poor, the systemic mode of chemotherapy for metastatic melanoma appears to be of only limited benefit. On the other hand, results from isolated limb perfusion for satellitosis and in-transit metastasis suggest distinct dose-response correlations with tumoricidal properties of appropriate antineoplastic agents. This experience prompted the idea to pilot the anti-tumor action of a high-dose regimen confined to one hemibody compartment for targeted tumor therapy. After having standardized the surgical procedure this goal appeared to be achievable by expanding the perfused area and by simultaneously detoxifying toxic drug levels within the non-perfused compartment by venous filtration. Two initial causal experiences revealed impressive tumor regressions and are therefore reported on preceding subsequent evaluation within a controlled clinical trial being designed at different solid tumors.

Adult↗
PubMed1989

[Use of high frequency ventilation in patients with respiratory insufficiency].

High frequency ventilation is very common today for treatment of patients with respiratory insufficiency in the ICU as well as intraoperatively. This special kind of artificial ventilation is suitable for patients with decreased lung volume and reduced thoracic and lung compliance. Favourable results in the treatment of ARDS are described. During high frequency ventilation the same degree of oxygenation and CO2-elimination can be reached as with conventional mechanical ventilation. The resulting lower peak and mean airway pressure is advantageous. Therefore the barotrauma of the lung is reduced during high frequency ventilation. For these reasons high frequency ventilation is an alternative method for ventilation of patients with so called "stiff lungs" with reduced thoracic and lung compliance.

Acid-Base Equilibrium↗
PubMed1989

[Equipment combination for the use of normal frequency and high frequency jet ventilation].

Over the last eight years high-frequency ventilation has been extensively evaluated both in the clinical and laboratory settings. Two types of jet ventilators for application of normofrequency and high-frequency jet ventilation have been developed. A combined equipment is described with gas mixer, heater-humidifier, monitoring, membrane solenoid valve and a special injection system.

High-Frequency Jet Ventilation↗
PubMed1989

[Experiences with the use of oscillating high frequency ventilation].

Our investigations have demonstrated that the effect of oscillatory high-frequency ventilation (HFO) on gas exchange in dogs is directly proportional to the oscillatory flow amplitude VM. Because of the equation: VM = PM/Z, gas exchange is increasing with rising oscillatory amplitude of the ventilation pressure PM and decreasing with rising impedance Z of the respiratory system. This system consists of endotracheal tube and the lungs of the dog investigated. The impedance Z = square root of R2 + X2 (resistance R and reactance X) achieves a minimal value near at the resonant frequency (reactance X = 0, in healthy intubated dogs near at 5 Hz) and increases with rising oscillatory frequency. Thus the oscillatory high-frequency ventilation is most effective near to the resonant frequency of the respiratory system. The results presented allow the conclusion that the application of high-frequency ventilation can be optimized by monitoring the respiratory mechanics parameters.

Animals↗
PubMed1988

[Venous hemodynamics in axillary venous stasis].

By means of venous-occlusion plethysmography in 40 patients (24 men, 16 women) with stasis of the axillary vein the venous return was measured. This was 62.3 +/- 21.5 ml/100 ml/min. on the healthy arm. Long-term venous thromboses had worse return values (43.7%) than short occlusions (71.6% of the healthy side). Responsible for the favourable late results, which express themselves in increasing return values, is in general the development of an efficient collateral circulation and recanalisation, respectively, after thrombolysis or thrombectomy. The plethysmographic measurement of the back flow apart from the phlebography of the arm is recommended for the diagnosis and control of the course of the stasis of the axillary vein.

Axillary Vein↗
PubMed1988

[The significance of inflammatory vascular diseases].

Out of the from angiological points of view most important inflammatory vascular diseases (obliterating endangiitis, giant cell arteriitis, Takayasu's disease) epidemiological data are compiled. Remarkable is the increasing part of female patients in endangiitis. Furthermore it is referred to the particular functional situation in these vascular diseases, which results from the localisation of a peripheral occlusion, insufficient formation of collaterals or disturbed rheology.

Aortic Arch Syndromes↗