Carcinoma in a Meckel's diverticulum: case report and literature review.
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Biomedical subjects
Publications and source records attributed to H W Adams.
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A patient with malignant fibrous histiocytoma had hematemesis from an ulcerated metastatic tumor in the stomach 3 years after surgical removal of the sarcoma from its primary site. Despite surgical removal of the ulcer and abdominal irradiation, the patient died from recurrent gastric tumor. A discussion of malignant fibrous histiocytoma and gastric metastases are presented.
The specific trophic effects of gastrointestinal hormones on gastric function are now recognized. In addition, pituitary, thyroid and adrenal hormones play an important role in maintaining over all gastric function. The majority of studies regarding hormonal effects on the stomach, however, have been carried out only in experimental animals. This paper reports a patient with gastric atrophy and hypopituitarism. Following therapy of the hypopituitarism with cortisone acetate, sodium levothyroxine and testosterone, the following observations were made: serum gastrin increased 137%; mucosal DNA synthesis and content and gastric acid secretion all increased. These data indicate in this one patient the role of these hormones in gastric function.
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The determination of whether metabolic homogeneity exists in an organ is of importance to both the clinician and investigator. These studies examine synthesis of DNA, RNA, protein, and oxygen uptake in the three anatomical segments of the rat pancreas. There was rather close agreement among the three segments insofar as these metabolic measurements were concerned. We concluded that there is metabolic uniformity in the rat pancreas and that measurements obtained in one segment reflect activities in the other two segments.
Blood-pressure and pulse-rate changes were evaluated prospectively in 50 patients undergoing uncomplicated liver biopsies and retrospectively in 4 patients who, since 1973, had recognized postbiopsy hemorrhage requiring transfusion. In uncomplicated biopsies a wide range of variations in vital signs was encountered between "baseline" and "before" controls and between controls and postbiopsy measurements. To place the changes in perspective, percentile scales were developed for percent maximum deviation from control for systolic blood pressure, diastolic blood pressure, and pulse rate. Analysis of changes in patients with significant hemorrhage revealed; (1) marked changes in vital signs in the early (2-hr) postbiopsy period; (2) the association of early hypertensive changes with pain followed by later evidence of hemorrhage in two of the four patients; (3) the lesser helpfulness of pulse change (1 of 4 bleeders) as compared to blood pressure change (4 of 4 patients).
Hypereosinophilic syndrome is a multisystem disease with progressive valvular dysfunction as a prominent feature. Ascites has not been recognized as a part of this syndrome. This paper presents a patient with hypereosinophilic syndrome who initially developed ascites and was recognized to have cardiac disease. The differential diagnosis of eosinophilic ascites is discussed.