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H W Dietl

Publications and source records attributed to H W Dietl.

3 recordsLinked to original sources
PubMed1986

A quantitative study of the cerebral cortex in Alzheimer's disease and senile dementia using an automatic image analyzing system.

The gray level index method was used in order to quantitatively differentiate the histological characteristics of a pathological population (n = 14) from those of a normal population (n = 14). An automatic image analysis system compared the laminar patterns in the straight gyrus of the cerebral cortex of deceased normal patients with those who died with Alzheimer's disease and senile dementia. In comparison to the normal control group, the cases with Alzheimer's disease and senile dementia show a significant decrease in the gray level index of lamina III.

Aged↗
PubMedDate not supplied

Brain involvement in generalized argyria.

Cutaneous argyria was diagnosed in a 59-year-old woman. Manic depressive psychosis developed at about the same or a short time thereafter. The patient died 6 years later from a ruptured aortic aneurysm. At autopsy silver deposits were seen in skin, mucous membranes, heart, kidney, and liver. In the central nervous system the leptomeninges and choroid plexuses contained silver granules. In addition, silver granules were visualized in the walls of many intraparenchymal vessels, particularly of the basal ganglia, hypothalamus, substantia nigra, and cerebellum. Progressive glial changes and cellular gliosis were evident in many areas of the brain. With the electron microscope the deposition of silver granules in basal membrane structures of the choroid plexus and intracerebral vasculature was amply confirmed. Furthermore, silver deposition was seen in brain parenchymal cells inside bodies of apparently lysosomal nature. The silver content of various brain regions was determined by absorption spectrophotometry.

Argyria↗